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[{"$nulls":3},"Mitochondria-Targeted Compound Library (96-well)-L9900"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 714 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L9900-01~09;    In 2 mM DMSO : Plate layout L9900-11"]
[{"$nulls":3},"In 10 mM Water: Plate layout L9900-10"]
[]
[]
[null,"Plate layout: L9900-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1002","S1068","S1141","S1210","S1351","S1501","S1680","S1759","S1905","S2055","Empty"]
[{"$nulls":3},"ABT-737","Crizotinib (PF-02341066)","Tanespimycin (17-AAG)","Methotrexate (CL-14377)","Ivermectin (MK-933)","Mycophenolate mofetil (RS-61443)","Disulfiram (NSC 190940)","Pitavastatin (NK-104) calcium","Amlodipine","Gimeracil"]
[null,"b","Empty","S1039","S1071","S1148","S1225","S1354","S1547","S1681","S1774","S1937","S2062","Empty"]
[{"$nulls":3},"Rapamycin (AY-22989)","HA14-1","Docetaxel (RP56976)","Etoposide (VP-16)","Lansoprazole","Febuxostat","Mesalamine (5-ASA)","Thioguanine (NSC 752)","Isoniazid","Tiopronin"]
[null,"c","Empty","S1042","S1076","S1150","S1233","S1378","S1619","S1693","S1792","S1949","S2102","Empty"]
[{"$nulls":3},"Sunitinib (SU11248) malate","Adezmapimod (SB203580)","Paclitaxel (NSC 125973)","2-Methoxyestradiol (2-MeOE2)","Ruxolitinib (INCB018424)","Prilocaine","Carbamazepine","Simvastatin (MK 733)","Menadione (NSC 4170)","Rasagiline Mesylate"]
[null,"d","Empty","S1047","S1092","S1168","S1238","S1389","S1630","S1712","S1794","S1950","S2105","Empty"]
[{"$nulls":3},"Vorinostat (SAHA)","KU-55933 (ATM Kinase Inhibitor)","Valproic Acid (NSC 93819) sodium salt","Tamoxifen (ICI 46474)","Omeprazole","Allopurinol","Deferasirox (ICL-670)","Fenofibrate (NSC-281319)","Metformin HCl","Pantoprazole"]
[null,"e","Empty","S1052","S1102","S1172","S1247","S1396","S1631","S1716","S1802","S1972","S2218","Empty"]
[{"$nulls":3},"Elesclomol (STA-4783)","U0126-EtOH","Serdemetan (JNJ-26854165)","Leflunomide (HWA486)","Resveratrol (SRT501)","Allopurinol Sodium","Glyburide (Glibenclamide)","AICAR (Acadesine)","Tamoxifen (ICI 46474) Citrate","Torkinib (PP242)"]
[null,"f","Empty","S1057","S1113","S1185","S1290","S1404","S1638","S1717","S1831","S1990","S2222","Empty"]
[{"$nulls":3},"Obatoclax Mesylate (GX15-070)","GSK690693","Ritonavir (ABT-538)","Celastrol (NSC 70931)","Trilostane","Ibuprofen (NSC 256857)","Fomepizole","Carvedilol","Capsaicin(Vanilloid)","PF-3716556"]
[null,"g","Empty","S1060","S1119","S1204","S1322","S1442","S1640","S1739","S1848","S1994","S2233","Empty"]
[{"$nulls":3},"Olaparib (AZD2281)","Cabozantinib (BMS-907351)","Melatonin (NSC 113928)","Dexamethasone (MK-125)","Voriconazole (UK-109496)","Albendazole (SKF-62979)","Thiabendazole","Curcumin","Lacidipine","Esomeprazole sodium"]
[null,"h","Empty","S1061","S1121","S1208","S1324","S1472","S1667","S1743","S1899","S2046","S2246","Empty"]
[{"$nulls":3},"Nutlin-3","TW-37","Doxorubicin (Adriamycin) HCl","Doxazosin Mesylate","Safinamide Mesylate","Trichlormethiazide","Esomeprazole magnesium","Nicotinamide (NSC 13128)","Pioglitazone HCl","Abiraterone Acetate (CB7630)"]
[]
[]
[]
[null,"Plate layout: L9900-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2250","S2300","S2326","S2343","S2376","S2448","S2586","S2776","S2930","S3603","Empty"]
[{"$nulls":3},"(-)-Epigallocatechin Gallate","Ferulic Acid","Myricetin","Phlorizin","Ammonium Glycyrrhizinate","Gambogic Acid","Dimethyl Fumarate","Devimistat (CPI-613)","Pifithrin-μ","Betulinic acid"]
[null,"b","Empty","S2263","S2302","S2329","S2348","S2390","S2485","S2605","S2781","S3017","S3612","Empty"]
[{"$nulls":3},"Arbutin","Glycyrrhizin (NSC 167409)","Naringin","Rotenone (Barbasco)","Polydatin","Mitoxantrone (NSC-301739) 2HCl","Idebenone","RITA (NSC 652287)","Aspirin (NSC 27223)","Rosmarinic acid"]
[null,"c","Empty","S2268","S2303","S2331","S2350","S2391","S2487","S2606","S2799","S3019","S3616","Empty"]
[{"$nulls":3},"Baicalein","Gossypol Acetate","Neohesperidin Dihydrochalcone (Nhdc)","Rutin","Quercetin (NSC 9221)","Mycophenolic acid","Mifepristone (RU486)","Daporinad","Ciclopirox ethanolamine","Asiaticoside"]
[null,"d","Empty","S2271","S2305","S2332","S2358","S2394","S2492","S2610","S2803","S3046","S3628","Empty"]
[{"$nulls":3},"Berberine chloride (NSC 646666)","Grape Seed Extract","Neohesperidin","Silymarin","Naringenin","Novobiocin Sodium (NSC 2382)","Lonidamine (AF-1890)","Galeterone","Azilsartan","BHQ"]
[null,"e","Empty","S2280","S2309","S2333","S2363","S2396","S2493","S2623","S2812","S3114","S3630","Empty"]
[{"$nulls":3},"Chlorogenic Acid","Hesperidin","Nobiletin (NSC 76751)","Tangeretin","Salidroside","Olanzapine","Omecamtiv mecarbil (CK-1827452)","(R)-(-)-Gossypol acetic acid","Vitamin C","Methyl Vanillate"]
[null,"f","Empty","S2289","S2310","S2337","S2369","S2399","S2528","S2631","S2843","S3124","S3643","Empty"]
[{"$nulls":3},"Daidzin","Honokiol (NSC 293100)","Osthole","Troxerutin","Dihydromyricetin","Ciclopirox","URB597","BI-D1870","Dexamethasone Acetate","Amitraz"]
[null,"g","Empty","S2295","S2314","S2339","S2370","S2423","S2553","S2730","S2910","S3212","S3652","Empty"]
[{"$nulls":3},"Emodin","Kaempferol (NSC 407289)","Paeonol","Ursolic Acid","(S)-10-Hydroxycamptothecin","5-Aminolevulinic acid HCl","Crenolanib (CP-868596)","Tempol","Moclobemide (Ro 111163)","3-Nitropropionic acid"]
[null,"h","Empty","S2296","S2320","S2341","S2371","S2425","S2554","S2757","S2929","S3600","S3654","Empty"]
[{"$nulls":3},"Enoxolone","Luteolin","(-)-Parthenolide","Vanillylacetone","Apocynin (NSC 2146)","Daphnetin","Evofosfamide (TH-302)","Pifithrin-α (PFTα) HBr","Schisandrin B (Sch B)","Tauroursodeoxycholic Acid (TUDCA)"]
[]
[]
[]
[null,"Plate layout: L9900-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3658","S3729","S3816","S3838","S3883","S3944","S4099","S4188","S4342","S4630","Empty"]
[{"$nulls":3},"O6-Benzylguanine","Iron sucrose","Dehydroevodiamine","Carnosic acid","Protopine","Valproic acid (VPA)","Dexlansoprazole","Sasapyrine","Nialamide","Diazoxide"]
[null,"b","Empty","S3660","S3765","S3817","S3839","S3885","S3957","S4100","S4206","S4353","S4662","Empty"]
[{"$nulls":3},"Uniconazole (S 3307D)","Picroside II","Harmine hydrochloride","1-Deoxynojirimycin","Pyrogallol","Gamma-Oryzanol","Esmolol HCl","Cysteamine HCl","Terfenadine","Atazanavir"]
[null,"c","Empty","S3665","S3783","S3824","S3840","S3905","S3969","S4104","S4212","S4511","S4686","Empty"]
[{"$nulls":3},"Trolox","Echinacoside","Quercitrin","Baohuoside I","Iso-Steviol","Veratric acid","Diminazene Aceturate","Tenatoprazole","6-Benzylaminopurine","Vitamin E"]
[null,"d","Empty","S3666","S3786","S3826","S3842","S3924","S3981","S4116","S4246","S4538","S4698","Empty"]
[{"$nulls":3},"Ilaprazole","Glabridin","Hydroxytyrosol","Isoquercitrin","Ginsenoside Rb1","Sinapinic Acid","Isovaleramide","Tranylcypromine (2-PCPA) HCl","Pantoprazole sodium","Vitamin K1"]
[null,"e","Empty","S3690","S3790","S3832","S3850","S3925","S3993","S4155","S4255","S4539","S4701","Empty"]
[{"$nulls":3},"Pargyline hydrochloride","Methyl gallate","Euphorbiasteroid","Glucosamine sulfate","(-)-Epicatechin gallate","Ethyl Vanillate","Chlorzoxazone","Quinacrine 2HCl","Salicylic acid","2-Deoxy-D-glucose (2-DG)"]
[null,"f","Empty","S3694","S3791","S3833","S3855","S3930","S3998","S4164","S4256","S4601","S4706","Empty"]
[{"$nulls":3},"Glucosamine hydrochloride","Succinic acid","Amentoflavone","Ethyl ferulate","Liquiritin","(+)-α-Lipoic acid","Doxofylline","Buspirone HCl","Clioquinol","Eugenol"]
[null,"g","Empty","S3695","S3804","S3834","S3868","S3937","S4007","S4166","S4263","S4603","S4707","Empty"]
[{"$nulls":3},"Cystamine dihydrochloride","Alpha-Mangostin","Astaxanthin","Harmine","Pterostilbene","Pentamidine isethionate","Chlorpropamide","Efaproxiral Sodium","Gallic acid","Oleic Acid"]
[null,"h","Empty","S3722","S3815","S3837","S3869","S3941","S4017","S4169","S4284","S4612","S4717","Empty"]
[{"$nulls":3},"Isavuconazole","Mogroside V","Echinocystic acid","Methyl protocatechuate","Pinocembrin","Allylthiourea","Teriflunomide","Chloroprocaine HCl","Dapson","Isatin"]
[]
[]
[]
[null,"Plate layout: L9900-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4722","S4809","S4999","S5208","S5317","S5454","S5663","S5795","S6008","S6441","Empty"]
[{"$nulls":3},"(+)-Catechin","3-Indolepropionic acid","Avermectin B1","Ciprofloxacin hydrochloride hydrate","UK 5099","Saikosaponin D","Minaprine dihydrochloride","Rasagiline","p-Hydroxybenzaldehyde","Riboflavin Tetrabutyrate"]
[null,"b","Empty","S4723","S4845","S5037","S5243","S5357","S5456","S5703","S5800","S6042","S6462","Empty"]
[{"$nulls":3},"(-)Epicatechin","Rabeprazole","Phenazine methosulfate","Ruxolitinib Phosphate","Safinamide","Isobavachalcone","Carvedilol Phosphate","Alda 1","Trimethylamine N-oxide dihydrate","Amezinium (methylsulfate)"]
[null,"c","Empty","S4746","S4853","S5058","S5266","S5369","S5464","S5709","S5804","S6163","S6494","Empty"]
[{"$nulls":3},"(20S)-Protopanaxadiol","Ecabet sodium","Revaprazan Hydrochloride","Stiripentol","Ethoxyquin","Psoralidin","Norgestrel","N-Acetylcysteine amide","Traumatic acid","CCCP"]
[null,"d","Empty","S4753","S4856","S5082","S5269","S5372","S5502","S5742","S5811","S6281","S6508","Empty"]
[{"$nulls":3},"Ganoderic acid A","Iproniazid","Vitamin K2","J147","Methyl Aminolevulinate Hydrochloride","Ilaprazole sodium","Deferoxamine mesylate (Ba 33112)","Kevetrin hydrochloride","Sodium Thiocyanate","Mitapivat"]
[null,"e","Empty","S4761","S4862","S5146","S5304","S5425","S5503","S5771","S5885","S6286","S7009","Empty"]
[{"$nulls":3},"Thymoquinone","Squalene","3-Methylpyrazole","2-Acetylphenothiazine (ML171)","Phenylglyoxal hydrate","O-Acetyl-L-carnitine hydrochloride","Sulforaphane","Rabeprazole Related Compound E","Tricarballylic acid","LCL161"]
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[{"$nulls":3},"β-thujaplicin","Tenovin-6","Tetrahydropiperine","Urolithin A","Quinacrine Dihydrochloride Dihydrate","Ethyl gallate","CY-09","CA-5f","Glucosamine","Merestinib (LY2801653)"]
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[{"$nulls":3},"Menadiol Diacetate","Usnic acid","Doxycycline","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","Berberine Sulfate","Flavokawain A","Trimetazidine","K 858","GK921","RG-7112"]
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[{"$nulls":3},"Carboxine","Nerol","2,6-Dihydroxyanthraquinone","NU2058","Sanguinarine chloride","Bedaquiline","Cyclic Pifithrin-α hydrobromide","Disufenton sodium","Lazabemide","Brefeldin A"]
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[{"$nulls":3},"GSK923295","Idasanutlin (RG-7388)","TEPP-46 (ML265)","AZD7545","GSK2578215A","Docetaxel Trihydrate","NCT-501","Dynasore","BH3I-1","Apoptozole"]
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[{"$nulls":3},"(-)-Blebbistatin","Bisindolylmaleimide IX (Ro 31-8220 Mesylate)","BAY 87-2243","UMI-77","PIK-III","BDA-366","MRT67307 HCl","Venetoclax (ABT-199)","NSC87877","Rbin-1"]
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[{"$nulls":3},"Marinopyrrole A (Maritoclax)","UNC0642","Q-VD-Oph","Lorlatinib (PF-6463922)","PRIMA-1","Oleuropein","MRT68921 HCl","Sabutoclax","Enasidenib (AG-221)","ML390"]
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[{"$nulls":3},"Mdivi-1","Vidofludimus","CORM-3","3PO","Ro-3306","SW033291","Tenovin-1","NSC59984","(±)-Shikonin","CBL0137 HCl"]
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[{"$nulls":3},"Setanaxib (GKT137831)","Golgicide A","BTB06584","MI-773 (SAR405838)","BPTES","MCB-613","Vonoprazan Fumarate (TAK-438)","GMX1778 (CHS828)","HA15","Tofogliflozin(CSG 452)"]
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[{"$nulls":3},"NCT-503","ULK-101","Apigetrin","Eriocitrin","3,4-Dimethoxycinnamic acid","Ginkgolic Acid","7ACC2","3-O-Acetyl-11-keto-β-boswellic acid (AKBA)","Merimepodib","BVT 2733"]
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[{"$nulls":3},"Diphenyleneiodonium chloride (DPI)","(20R)Ginsenoside Rg3","Chicoric acid","Schaftoside","1,4-Naphthoquinone","Pomolic acid","Inauhzin","Dihydrocapsaicin","CM272","ML216"]
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[{"$nulls":3},"BTSA1","Sanguinarine","Epiberberine","Alisol B","Dihydrocoumarin","Vasicine","ML364","Fadrozole (CGS16949A)","Olutasidenib (FT-2102)","Triglycidyl Isocyanurate (Teroxirone)"]
[]
[]
[]
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[{"$nulls":3},"Ellipticine hydrochloride","CBL0137","Cinobufagin","Myristicin","Mitoquinone (MitoQ10) mesylate","COH-29","JX06","Phillygenin","CM10","Ensulizole"]
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[{"$nulls":3},"CDN1163","Isuzinaxib (APX-115 free base)","5,7-Dimethoxyflavone","Cynarin","IM156","Alsterpaullone","GW6471","Ginsenoside Rk1","AKR1C1-IN-1","Rifamycin S"]
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[{"$nulls":3},"Bufalin","CADD522","Resibufogenin","RA-190","ABTL-0812","BAM 15","4-Methyl-2-oxovaleric acid","Raddeanin A","CTPI-2","Iproniazid phosphate"]
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[{"$nulls":3},"VLX600","BL-918","Nodakenetin","Gossypol","H2DCFDA","Adjudin","Pyruvic acid","G6PDi-1","Mitochondrial Fusion Promoter M1","Tetraethylammonium chloride"]
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[{"$nulls":3},"HQNO","Navitoclax (ABT-263)","Atractyloside potassium salt","HI-TOPK-032","(E/Z)-BCI","KM91104","SEA0400","CBR-5884","GSK5182","Iohexol"]
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[{"$nulls":3},"SBI-797812","Tenovin-3","Kaempferol-3-O-rutinoside","1-Aminobenzotriazole","APD597","Mitochonic acid 5","Perhexiline maleate","FICZ","Brequinar Sodium","Enasidenib Mesylate"]
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[{"$nulls":3},"GLX351322","Perillaldehyde","Hypericin","GSK 2837808A","BRITE338733","4',5,7-Trimethoxyflavone","TPEN","Ciliobrevin D","Rhodamine 123","Crizotinib hydrochloride"]
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[{"$nulls":3},"ML241 hydrochloride","Raspberry ketone glucoside","Senkyunolide I","GSK2795039","2-DI-1-ASP","AC1903","Ziyuglycoside II","ML367","Rhodamine 6G","Pantoprazole sodium hydrate"]
[]
[]
[]
[null,"Plate layout: L9900-08"]
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[{"$nulls":3},"L-Carnitine hydrochloride","GW406108X","Linderalactone","Imeglimin (EMD 387008) Hydrochloride","CCI-007","PfDHODH-IN-2","Glutaminase C-IN-1","EGCG Octaacetate","1-Methoxy PMS","APG-2575 (lisaftoclax)"]
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[{"$nulls":3},"Metformin","Visomitin (SKQ1)","2-Hydroxybenzylamine","Tegoprazan","MSDC-0602K Potassium","BI-6C9","Norharmane","Spastazoline","A-1155463 Dihydrochloride","CVT-10216"]
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[{"$nulls":3},"Farudodstat","Mito-TEMPO","Olesoxime (TRO 19622)","Phenelzine sulfate","SJ-172550","BIA","BT2","Salvianolic acid C","A-1331852","ZZW-115"]
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[{"$nulls":3},"6-Aminonicotinamide","AG-636","ML240","10-Deacetyl-7-xylosyl paclitaxel","Calmidazolium chloride","SIRT7 inhibitor 97491","Alkannin","Cyclophosphamide","Nutlin-3a","Emvododstat (PTC299)"]
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[{"$nulls":3},"LC3-mHTT-IN-AN1","MCU-i4","MRT67307","DHODH-IN-11","TMS","tetrathiomolybdate","LCS-1","ER-000444793","Salinomycin (from Streptomyces albus)","MF-094"]
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[{"$nulls":3},"MPP+ iodide","BC1618","Obatoclax (GX15-070)","NL-1","Deacetylasperulosidic acid","R162","Procyanidin B2","Liarozole dihydrochloride","VU661013","DX3-213B"]
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[{"$nulls":3},"TCPOBOP","MYLS22","Azemiglitazone (MSDC-0602)","Camalexin","AA147","FHD-286","Oleandrin (PBI-05204)","(R)-GNE-140","DS-1001b (DS 1001)","BAY-179"]
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[{"$nulls":3},"Levomefolic acid","Harmane","OT-82","DC-05","Paprotrain","Valepotriate","Deslanoside","Telacebec (Q203)","ACBI1","LDC195943 (IMT1)"]
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[{"$nulls":3},"TP-1454","Sulfosuccinimidyl oleate sodium","POMHEX"]
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[{"$nulls":3},"AZD1656","Ruthenium Red","Phenylarsine oxide"]
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[{"$nulls":3},"Sodium Pyruvate","Adaptaquin"]
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[{"$nulls":3},"Etidronate","Amifostine trihydrate","3-Aminopropionitrile fumarate","Ac-DEVD-CHO","L-Histidine monohydrochloride monohydrate","NADPH tetrasodium salt"]
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[{"$nulls":3},"D-glutamine","Glutathione","DL-Serine","Ruxotemitide (LTX 315)","Elamipretide (MTP-131)"]
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[{"$nulls":3},"Sodium orthovanadate","Sodium ferulate","Citronellol","bpV (HOpic)","L-Albizziin"]
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[{"$nulls":3},"NAD+","S-Methyl-L-cysteine","Creatine","Lithium carbonate","Ammonium ferric citrate"]
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[{"$nulls":3},"(S)-Methylisothiourea sulfate","Manganese chloride","Inosine 5′-triphosphate trisodium salt","Sodium oxamate","L-Ascorbic acid 2-phosphate sesquimagnesium salt"]
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[{"$nulls":3},"L-SelenoMethionine","Riboflavin phosphate sodium","Adenosine 5′-diphosphate sodium salt","Motixafortide (BL-8040)","D-AP5"]
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[{"$nulls":3},"Sodium Monofluorophosphate","L-carnosine","Disodium (R)-2-Hydroxyglutarate","L-2-Hydroxyglutaric acid disodium","DL-AP5 (2-APV)"]
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[{"$nulls":3},"Vandetanib (ZD6474)","Chelerythrine"]
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[{"$nulls":3},"Pseudoprotodioscin"]

{"sheet":"L9900-Mitochondria-714 cpds","index":1,"n_rows":715,"n_cols":23,"rows_kept":715}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1002","ABT-737","a2","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Mitophagy","Apoptosis","ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.",813.43,"852808-04-9",{"v":100,"d":"100.00"},122.94,"<1","N/A","http://selleckchem.com/products/ABT-737.html","C42H45ClN6O5S2","free base","N/A","CN(C)CCC(CSC1=CC=CC=C1)NC2=CC=C(C=C2[N+]([O-])=O)[S](=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=C(C=CC=C5)C6=CC=C(Cl)C=C6",8.198,3,2,16]
["S1039","Rapamycin (AY-22989)","b2","L9900-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,mTOR","PI3K/Akt/mTOR","Rapamycin (AY-22989, Rapamune, Sirolimus, NSC-2260804,AY-22989) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.",914.18,"53123-88-9",{"v":20,"d":"20.00"},21.88,"<1","N/A","http://selleckchem.com/products/Rapamycin.html","C51H79NO13","free base","Rapamune, Sirolimus, NSC-2260804,AY-22989","COC1CC(CCC1O)CC(C)C2CC(=O)C(C)\\C=C(/C)C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.295,10,2,6]
["S1042","Sunitinib (SU11248) malate","c2","L9900-01","in 10mM DMSO","Apoptosis related,c-Kit,IRE1,Mitophagy,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.",532.56,"341031-54-7",{"v":15,"d":"15.00"},28.17,"<1","N/A","http://selleckchem.com/products/Sunitinib-Malate-(Sutent).html","C22H27FN4O2.C4H6O5","Malate","N/A","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=CC=C(F)C=C23.OC(CC(O)=O)C(O)=O",-1.049,4,4,10]
["S1047","Vorinostat (SAHA)","d2","L9900-01","in 10mM DMSO","Autophagy,HDAC,HPV","Epigenetics","Vorinostat (SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.",{"v":264.3,"d":"264.30"},"149647-78-9",{"v":52,"d":"52.00"},196.75,"<1","N/A","http://selleckchem.com/products/Vorinostat-saha.html","C14H20N2O3","free base","SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza","ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1",2.005,2,2,8]
["S1052","Elesclomol (STA-4783)","e2","L9900-01","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.",{"v":400.5,"d":"400.50"},"488832-69-5",{"v":80,"d":"80.00"},199.75,"<1","N/A","http://selleckchem.com/products/Elesclomol.html","C19H20N4O2S2","free base","N/A","CN(NC(=O)CC(=O)NN(C)C(=S)C1=CC=CC=C1)C(=S)C2=CC=CC=C2",2.885,2,2,8]
["S1057","Obatoclax Mesylate (GX15-070)","f2","L9900-01","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.",413.49,"803712-79-0",{"v":83,"d":"83.00"},200.73,"<1","N/A","http://selleckchem.com/products/Obatoclax-Mesylate.html","C20H19N3O.CH4O3S","Mesylate","N/A","COC\\1=CC(=NC1=C\\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O",3.757,2,2,3]
["S1060","Olaparib (AZD2281)","g2","L9900-01","in 10mM DMSO","Autophagy,Mitophagy,PARP","DNA Damage/DNA Repair","Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.",434.46,"763113-22-0",{"v":86,"d":"86.00"},197.95,"N/A","N/A","http://selleckchem.com/products/AZD2281(Olaparib).html","C24H23FN4O3","free base","Ku-0059436","FC1=C(C=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1)C(=O)N4CCN(CC4)C(=O)C5CC5",2.127,4,1,4]
["S1061","Nutlin-3","h2","L9900-01","in 10mM DMSO","E3 Ligase ,MDM2/MDMX","Apoptosis","Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.",{"v":581.5,"d":"581.50"},"890090-75-2",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/Nutlin-3.html","C30H30Cl2N4O4","free base","N/A","COC1=CC(=C(C=C1)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)OC(C)C",5.434,5,1,6]
["S1068","Crizotinib (PF-02341066)","a3","L9900-01","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",450.34,"877399-52-5",{"v":9,"d":"9.00"},19.98,"<1","N/A","http://selleckchem.com/products/PF-2341066.html","C21H22Cl2FN5O","free base","PF-02341066","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S1071","HA14-1","b3","L9900-01","in 10mM DMSO","Bcl-2","Apoptosis","HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.",409.23,"65673-63-4",{"v":82,"d":"82.00"},200.38,"<1","N/A","http://selleckchem.com/products/HA14-1.html","C17H17BrN2O5","free base","N/A","CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Br",2.511,5,1,7]
["S1076","Adezmapimod (SB203580)","c3","L9900-01","in 10mM DMSO","Mitophagy,p38 MAPK","MAPK","Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.",377.43,"152121-47-6",{"v":43,"d":"43.00"},113.93,"<1","N/A","http://selleckchem.com/products/SB-203580.html","C21H16FN3OS","Free Base","RWJ 64809, PB 203580","C[S](=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",3.883,3,1,4]
["S1092","KU-55933 (ATM Kinase Inhibitor)","d3","L9900-01","in 10mM DMSO","ATM/ATR,Autophagy,ULK","DNA Damage/DNA Repair","KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.",395.49,"587871-26-9",{"v":33,"d":"33.00"},83.44,"<1","N/A","http://selleckchem.com/products/KU-55933.html","C21H17NO3S2","free base","N/A","O=C1C=C(OC(=C1)C2=CC=CC3=C2SC4=CC=CC=C4S3)N5CCOCC5",4.393,3,0,2]
["S1102","U0126-EtOH","e3","L9900-01","in 10mM DMSO","Antiviral,Autophagy,MEK,Mitophagy","MAPK","U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.",426.56,"1173097-76-1",{"v":85,"d":"85.00"},199.27,"<1","N/A","http://selleckchem.com/products/U0126.html","C18H16N6S2.C2H6O","Ethanolate","N/A","CCO.N\\C(SC1=CC=CC=C1N)=C(C#N)\\C(C#N)=C(N)/SC2=CC=CC=C2N",2.169,0,5,5]
["S1113","GSK690693","f3","L9900-01","in 10mM DMSO","Akt,AMPK,Autophagy,DAPK,PKA,PKC,STING,ULK","PI3K/Akt/mTOR","GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.",425.48,"937174-76-0",{"v":39,"d":"39.00"},91.66,"<1","N/A","http://selleckchem.com/products/GSK690693.html","C21H27N7O3","free base","N/A","CC[N]1C(=NC2=C1C(=CN=C2C#CC(C)(C)O)OCC3CCCNC3)C4=NON=C4N",1.839,6,2,7]
["S1119","Cabozantinib (BMS-907351)","g3","L9900-01","in 10mM DMSO","Apoptosis related,Axl,c-Met,VEGFR","Protein Tyrosine Kinase","Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.",501.51,"849217-68-1",{"v":100,"d":"100.00"},{"v":199.4,"d":"199.40"},"<1","N/A","http://selleckchem.com/products/XL184.html","C28H24FN3O5","Free Base","XL184,BMS-907351","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3",4.342,6,2,8]
["S1121","TW-37","h3","L9900-01","in 10mM DMSO","Bcl-2","Apoptosis","TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.",{"v":573.7,"d":"573.70"},"877877-35-5",{"v":115,"d":"115.00"},200.45,"<1","N/A","http://selleckchem.com/products/TW-37.html","C33H35NO6S","free base","N/A","CC(C)C1=CC=CC=C1CC2=CC(=C(O)C(=C2O)O)C(=O)NC3=CC=C(C=C3)[S](=O)(=O)C4=C(C=CC=C4)C(C)(C)C",{"v":7.56,"d":"7.560"},3,4,8]
["S1141","Tanespimycin (17-AAG)","a4","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),Mitophagy","Cytoskeletal Signaling","Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.",585.69,"75747-14-7",{"v":100,"d":"100.00"},170.74,"<1","N/A","http://selleckchem.com/products/17-AAG(Geldanamycin).html","C31H43N3O8","free base","CP127374, NSC-330507, KOS 953","COC1CC(C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.524,7,4,7]
["S1148","Docetaxel (RP56976)","b4","L9900-01","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",807.88,"114977-28-5",{"v":100,"d":"100.00"},123.78,"<1","N/A","http://selleckchem.com/products/Docetaxel(Taxotere).html","C43H53NO14","Free Base","NSC 628503,RP56976","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",2.586,10,4,13]
["S1150","Paclitaxel (NSC 125973)","c4","L9900-01","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.",853.91,"33069-62-4",{"v":171,"d":"171.00"},200.26,"<1","N/A","http://selleckchem.com/products/Paclitaxel(Taxol).html","C47H51NO14","free base","PTX, Taxol, Onxal, Abraxane,NSC 125973","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C1C5(C)C)C",3.055,11,3,14]
["S1168","Valproic Acid (NSC 93819) sodium salt","d4","L9900-01","in 10mM DMSO","Autophagy,GABA Receptor,HDAC,Mitophagy,Notch,PGC-1α","Neuronal Signaling","Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.",166.19,"1069-66-5",{"v":33,"d":"33.00"},198.57,{"v":33,"d":"33.00"},198.57,"http://selleckchem.com/products/Sodium-valproate.html","C8H15NaO2","Sodium salt","Sodium valproate,NSC 93819,2-Propylpentanoic Acid","CCCC(CCC)C(=O)O[Na]",1.275,0,0,5]
["S1172","Serdemetan (JNJ-26854165)","e4","L9900-01","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.",328.41,"881202-45-5",{"v":66,"d":"66.00"},200.97,"<1","N/A","http://selleckchem.com/products/JNJ-26854165.html","C21H20N4","free base","N/A","C(CC1=C[NH]C2=CC=CC=C12)NC3=CC=C(NC4=CC=NC=C4)C=C3",4.236,1,3,6]
["S1185","Ritonavir (ABT-538)","f4","L9900-01","in 10mM DMSO","Apoptosis related,COVID-19,HIV Protease,P450 (e.g. CYP17)","Proteases","Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.",720.94,"155213-67-5",{"v":100,"d":"100.00"},138.71,"<1","N/A","http://selleckchem.com/products/Ritonavir.html","C37H48N6O5S2","free base","ABT-538,A 84538, RTV, Norvir, Norvir Softgel","CC(C)C(NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)NC(CC(O)C(CC2=CC=CC=C2)NC(=O)OCC3=CN=CS3)CC4=CC=CC=C4",4.978,6,4,18]
["S1204","Melatonin (NSC 113928)","g4","L9900-01","in 10mM DMSO","Apoptosis related,ATF/CREB & c-Fos/c-Jun,Autophagy,COX,Mitophagy,MT Receptor","GPCR & G Protein","Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine,MT) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.",232.28,"73-31-4",{"v":47,"d":"47.00"},202.34,"<1","N/A","http://selleckchem.com/products/Melatonin.html","C13H16N2O2","free base","NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT","COC1=CC2=C([NH]C=C2CCNC(C)=O)C=C1",1.555,2,2,4]
["S1208","Doxorubicin (Adriamycin) HCl","h4","L9900-01","in 10mM DMSO","ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.",579.98,"25316-40-9",{"v":100,"d":"100.00"},172.42,{"v":20,"d":"20.00"},34.48,"http://selleckchem.com/products/Adriamycin.html","C27H29NO11.HCl","Hydrochloride","NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1210","Methotrexate (CL-14377)","a5","L9900-01","in 10mM DMSO","ADC Cytotoxin,DHFR","Metabolism","Methotrexate (CL14377, MTX, NCI-C04671, Amethopterin, WR19039, abitrexate), analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.",454.44,"59-05-2",{"v":90,"d":"90.00"},198.05,"<1","N/A","http://selleckchem.com/products/Abitrexate.html","C20H22N8O5","free base","NCI-C04671, Amethopterin, CL14377, WR19039, abitrexate","CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",0.114,7,3,9]
["S1225","Etoposide (VP-16)","b5","L9900-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Etoposide (VP-16213,Vepesid,VP-16) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II  inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.",588.56,"33419-42-0",{"v":100,"d":"100.00"},169.91,"<1","N/A","http://selleckchem.com/products/Etopophos.html","C29H32O13","free base","VP-16213,Vepesid,VP-16","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(C)OC5C(O)C4O)C6=C2C=C7OCOC7=C6",0.935,10,3,5]
["S1233","2-Methoxyestradiol (2-MeOE2)","c5","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,HIF,Microtubule Associated","Angiogenesis","2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines.",302.41,"362-07-2",{"v":60,"d":"60.00"},198.41,"<1","N/A","http://selleckchem.com/products/2-Methoxyestradiol(2ME2).html","C19H26O3","free base","NSC 659853, 2-ME2","COC1=C(O)C=C2CCC3C(CCC4(C)C(O)CCC34)C2=C1",3.821,1,2,1]
["S1238","Tamoxifen (ICI 46474)","d5","L9900-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,ATPase,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Angiogenesis","Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.",371.51,"10540-29-1",{"v":74,"d":"74.00"},199.19,"<1","N/A","http://selleckchem.com/products/Nolvadex.html","C26H29NO","Free Base","ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1247","Leflunomide (HWA486)","e5","L9900-01","in 10mM DMSO","AhR,Dehydrogenase","Metabolism","Leflunomide (HWA486, RS-34821, SU101, Arava) is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of Leflunomide is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). Leflunomide is also an agonist of the AhR.",270.21,"75706-12-6",{"v":54,"d":"54.00"},199.84,"<1","N/A","http://selleckchem.com/products/Leflunomide.html","C12H9F3N2O2","free base","HWA486, RS-34821, SU101, Arava","CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F",2.156,3,1,3]
["S1290","Celastrol (NSC 70931)","f5","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,Proteasome","Proteases","Celastrol (NSC 70931, Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.",450.61,"34157-83-0",{"v":90,"d":"90.00"},199.73,"<1","N/A","http://selleckchem.com/products/Celastrol.html","C29H38O4","free base","Tripterine","CC1=C(O)C(=O)C=C2C1=CC=C3C2(C)CCC4(C)C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.475,2,1,1]
["S1322","Dexamethasone (MK-125)","g5","L9900-01","in 10mM DMSO","Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy","Immunology & Inflammation","Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.",392.46,"50-02-2",{"v":79,"d":"79.00"},201.29,"<1","N/A","http://selleckchem.com/products/Dexamethasone.html","C22H29FO5","free base","NSC 34521, Hexadecadrol, Prednisolone F,MK-125","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1324","Doxazosin Mesylate","h5","L9900-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.",547.58,"77883-43-3",{"v":15,"d":"15.00"},27.39,"<1","N/A","http://selleckchem.com/products/Doxazosin-mesylate.html","C23H25N5O5.CH4O3S","Mesylate","N/A","COC1=C(OC)C=C2C(=NC(=NC2=C1)N3CCN(CC3)C(=O)C4COC5=C(O4)C=CC=C5)N.C[S](O)(=O)=O",2.071,7,1,4]
["S1351","Ivermectin (MK-933)","a6","L9900-01","in 10mM DMSO","AChR,Autophagy,Chloride Channel,COVID-19,HIV,Mitophagy,P2 Receptor","Transmembrane Transporters","Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.",875.09,"70288-86-7",{"v":100,"d":"100.00"},114.27,"<1","N/A","http://selleckchem.com/products/Ivermectin.html","C48H74O14","Free Base","MK-933","CCC(C)C1OC2(CCC1C)CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2",4.743,11,2,8]
["S1354","Lansoprazole","b6","L9900-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. Lansoprazole prevents the stomach from producing gastric acid.",369.36,"103577-45-3",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/Lansoprazole.html","C16H14F3N3O2S","free base","A-65006, AG-1749","CC1=C(OCC(F)(F)F)C=CN=C1C[S](=O)C2=NC3=CC=CC=C3[NH]2",3.442,4,1,6]
["S1378","Ruxolitinib (INCB018424)","c6","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",306.37,"941678-49-5",{"v":61,"d":"61.00"},199.11,"<1","N/A","http://selleckchem.com/products/INCB18424.html","C17H18N6","free base","INCB018424","N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":2.88,"d":"2.880"},3,1,4]
["S1389","Omeprazole","d6","L9900-01","in 10mM DMSO","ATPase,Autophagy,Proton Pump","Transmembrane Transporters","Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.",345.42,"73590-58-6",{"v":69,"d":"69.00"},199.76,"<1","N/A","http://selleckchem.com/products/Omeprazole.html","C17H19N3O3S","free base","N/A","COC1=CC=C2[NH]C(=NC2=C1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.904,5,1,5]
["S1396","Resveratrol (SRT501)","e6","L9900-01","in 10mM DMSO","AMPK,Apoptosis related,Autophagy,COX,ERK,IκB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT","Autophagy","Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.",228.24,"501-36-0",{"v":45,"d":"45.00"},197.16,"<1","N/A","http://selleckchem.com/products/Resveratrol.html","C14H12O3","free base","trans-Resveratrol,SRT501","OC1=CC=C(C=C1)\\C=C\\C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S1404","Trilostane","f6","L9900-01","in 10mM DMSO","Dehydrogenase","Metabolism","Trilostane (WIN 24540) is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.",329.43,"13647-35-3",{"v":65,"d":"65.00"},197.31,"<1","N/A","http://selleckchem.com/products/Trilostane.html","C20H27NO3","free base","WIN 24540","CC12CCC3C(CCC45OC4C(=C(CC35C)C#N)O)C1CCC2O",2.434,1,2,0]
["S1442","Voriconazole (UK-109496)","g6","L9900-01","in 10mM DMSO","Fungal,P450 (e.g. CYP17)","Metabolism","Voriconazole (Vfend,UK-109496) is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.",349.31,"137234-62-9",{"v":70,"d":"70.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/Voriconazole.html","C16H14F3N5O","free base","Vfend,UK-109496","CC(C1=NC=NC=C1F)C(O)(C[N]2C=NC=N2)C3=CC=C(F)C=C3F",2.071,4,0,5]
["S1472","Safinamide Mesylate","h6","L9900-01","in 10mM DMSO","MAO","Metabolism","Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.",398.45,"202825-46-5",{"v":80,"d":"80.00"},200.78,{"v":80,"d":"80.00"},200.78,"http://selleckchem.com/products/Safinamide-mesilate.html","C17H19FN2O2.CH4O3S","Mesylate","PNU-151774E,FCE28073","CC(NCC1=CC=C(OCC2=CC(=CC=C2)F)C=C1)C(N)=O.C[S](O)(=O)=O",2.064,2,2,7]
["S1501","Mycophenolate mofetil (RS-61443)","a7","L9900-01","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","Mycophenolate Mofetil (RS 61443, Mycophenolic acid morpholinoethyl ester, CellCept, TM-MMF) is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Mycophenolate Mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.",433.49,"128794-94-5",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/Mycophenolate-mofetil-(CellCept).html","C23H31NO7","free base","Mycophenolic acid morpholinoethyl ester, CellCept, RS 61443, TM-MMF","COC1=C(C)C2=C(C(=O)OC2)C(=C1C\\C=C(C)\\CCC(=O)OCCN3CCOCC3)O",3.209,6,1,10]
["S1547","Febuxostat","b7","L9900-01","in 10mM DMSO","ROS","Immunology & Inflammation","Febuxostat (TMX 67, TEI-6720) is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.",316.37,"144060-53-7",{"v":63,"d":"63.00"},199.13,"<1","N/A","http://selleckchem.com/products/Febuxostat(Uloric).html","C16H16N2O3S","free base","TMX 67, TEI-6720","CC(C)COC1=C(C=C(C=C1)C2=NC(=C(S2)C(O)=O)C)C#N",3.468,3,0,5]
["S1619","Prilocaine","c7","L9900-01","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Prilocaine (NSC 40027) is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.",220.31,"721-50-6",{"v":44,"d":"44.00"},199.72,"<1","N/A","http://selleckchem.com/products/Prilocaine.html","C13H20N2O","free base","NSC 40027","CCCNC(C)C(=O)NC1=C(C)C=CC=C1",2.263,1,2,5]
["S1630","Allopurinol","d7","L9900-01","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.",136.11,"315-30-0",{"v":27,"d":"27.00"},198.37,{"v":4,"d":"4.00"},29.39,"http://selleckchem.com/products/Allopurinol(Zyloprim).html","C5H4N4O","Free Base","N/A","O=C1N=CN=C2NNC=C12",-2.125,3,2,0]
["S1631","Allopurinol Sodium","e7","L9900-01","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol Sodium  is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.",{"v":159.1,"d":"159.10"},"17795-21-0",{"v":32,"d":"32.00"},201.13,{"v":32,"d":"32.00"},201.13,"http://selleckchem.com/products/Allopurinol-Sodium(Aloprim).html","C5H4N4NaO","Sodium Salt","N/A","[Na+].O=C1NC=NC2=C1C=N[NH]2",-0.681,3,2,0]
["S1638","Ibuprofen (NSC 256857)","f7","L9900-01","in 10mM DMSO","COX","Neuronal Signaling","Ibuprofen (NSC 256857, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.",206.28,"15687-27-1",{"v":41,"d":"41.00"},198.76,"<1","N/A","http://selleckchem.com/products/Ibuprofen(Advil).html","C13H18O2","free base","Dolgesic,NSC 256857","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O",3.607,1,0,4]
["S1640","Albendazole (SKF-62979)","g7","L9900-01","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.",265.33,"54965-21-8",{"v":17,"d":"17.00"},64.07,"<1","N/A","http://selleckchem.com/products/Albendazole(Albenza).html","C12H15N3O2S","free base","SKF-62979","CCCSC1=CC=C2N=C(NC(=O)OC)[NH]C2=C1",3.065,3,2,5]
["S1667","Trichlormethiazide","h7","L9900-01","in 10mM DMSO","Others","Others","Trichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide.",380.66,"133-67-5",{"v":54,"d":"54.00"},141.86,"<1","N/A","http://selleckchem.com/products/Trichlormethiazide(Achletin).html","C8H8Cl3N3O4S2","free base","N/A","N[S](=O)(=O)C1=C(Cl)C=C2NC(N[S](=O)(=O)C2=C1)C(Cl)Cl",1.046,4,3,2]
["S1680","Disulfiram (NSC 190940)","a8","L9900-01","in 10mM DMSO","Apoptosis related,COVID-19,Dehydrogenase,Pyroptosis","Metabolism","Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).",296.54,"97-77-8",{"v":59,"d":"59.00"},198.96,"<1","N/A","http://selleckchem.com/products/Disulfiram(Antabuse).html","C10H20N2S4","free base","NSC 190940, Tetraethylthiuram disulfide, TETD","CCN(CC)C(=S)SSC(=S)N(CC)CC",{"v":5.6,"d":"5.600"},0,0,9]
["S1681","Mesalamine (5-ASA)","b8","L9900-01","in 10mM DMSO","Immunology & Inflammation related,IκB/IKK","NF-κB","Mesalamine (5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.",153.14,"89-57-6",{"v":31,"d":"31.00"},202.43,"<1","N/A","http://selleckchem.com/products/Mesalamine(Lialda).html","C7H7NO3","free base","5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa","NC1=CC=C(O)C(=C1)C(O)=O",0.471,1,2,1]
["S1693","Carbamazepine","c8","L9900-01","in 10mM DMSO","Autophagy,Sodium Channel","Transmembrane Transporters","Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.",236.27,"298-46-4",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://selleckchem.com/products/Carbamazepine(Carbatrol).html","C15H12N2O","free base","NSC 169864","NC(=O)N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",2.679,1,1,0]
["S1712","Deferasirox (ICL-670)","d8","L9900-01","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17)","Proteases","Deferasirox (ICL-670, CGP-72670) is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death.",373.36,"201530-41-8",{"v":74,"d":"74.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/Deferasirox(Exjade).html","C21H15N3O4","free base","CGP-72670, ICL-670","OC(=O)C1=CC=C(C=C1)[N]2N=C(N=C2C3=CC=CC=C3O)C4=CC=CC=C4O",4.063,3,2,4]
["S1716","Glyburide (Glibenclamide)","e8","L9900-01","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.",{"v":494,"d":"494.00"},"10238-21-8",{"v":99,"d":"99.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/Glyburide(Diabeta).html","C23H28ClN3O5S","free base","Glibenclamide","COC1=C(C=C(Cl)C=C1)C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCCCC3",{"v":4.14,"d":"4.140"},5,3,8]
["S1717","Fomepizole","f8","L9900-01","in 10mM DMSO","Dehydrogenase","Metabolism","Fomepizole (4-methylpyrazole, Antizol, Antizol-Vet) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.",{"v":82.1,"d":"82.10"},"7554-65-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/Fomepizole(Antizol).html","C4H6N2","free base","4-methylpyrazole, Antizol, Antizol-Vet","CC1=C[NH]N=C1",{"v":0.76,"d":"0.760"},1,1,0]
["S1739","Thiabendazole","g8","L9900-01","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property, used as an anthelmintic and fungicide agent. It is a potent inhibitor of  cytochrome P450 1A2 (CYP1A2).",201.25,"148-79-8",{"v":40,"d":"40.00"},198.76,"<1","N/A","http://selleckchem.com/products/Thiabendazole.html","C10H7N3S","free base","N/A","[NH]1C2=C(C=CC=C2)N=C1C3=CSC=N3",2.154,2,1,1]
["S1743","Esomeprazole magnesium","h8","L9900-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.",713.12,"161973-10-0",{"v":143,"d":"143.00"},200.53,"<1","N/A","http://selleckchem.com/products/nexium-esomeprazole-magnesium.html","C34H36MgN6O6S2","Magnesium salt","NEXIUM","[Mg++].COC1=CC2=C([N-]C(=N2)[S](=O)CC3=C(C)C(=C(C)C=N3)OC)C=C1.COC4=CC5=C([N-]C(=N5)[S](=O)CC6=NC=C(C)C(=C6C)OC)C=C4",{"v":6.1,"d":"6.100"},10,0,10]
["S1759","Pitavastatin (NK-104) calcium","a9","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,HMG-CoA Reductase,Mitophagy","Metabolism","Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.",880.98,"147526-32-7",{"v":51,"d":"51.00"},57.89,"<1","N/A","http://selleckchem.com/products/Pitavastatin-calcium(Livalo).html","C50H46CaF2N2O8","Calcium salt","NK-104, P-872441, itavastatin, nisvastatin","[Ca++].OC(CC(O)C=CC1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4)CC([O-])=O.OC(CC(O)C=CC5=C(C6=CC=C(F)C=C6)C7=CC=CC=C7N=C5C8CC8)CC([O-])=O",{"v":4.96,"d":"4.960"},2,4,16]
["S1774","Thioguanine (NSC 752)","b9","L9900-01","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.",167.19,"154-42-7",{"v":9,"d":"9.00"},53.83,"<1","N/A","http://selleckchem.com/products/Thioguanine.html","C5H5N5S","free base","NSC 752,6-Thioguanine, 2-Amino-6-purinethiol","NC1=NC(=S)C2=C(N1)N=C[NH]2",0.236,2,3,0]
["S1792","Simvastatin (MK 733)","c9","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,HMG-CoA Reductase,Mitophagy","Metabolism","Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.",418.57,"79902-63-9",{"v":83,"d":"83.00"},198.29,"<1","N/A","http://selleckchem.com/products/Simvastatin(Zocor).html","C25H38O5","free base","MK-0733, MK 733","CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.634,4,1,7]
["S1794","Fenofibrate (NSC-281319)","d9","L9900-01","in 10mM DMSO","Autophagy,P450 (e.g. CYP17),PPAR","Metabolism","Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.",360.83,"49562-28-9",{"v":72,"d":"72.00"},199.54,"<1","N/A","http://selleckchem.com/products/Fenofibrate(Tricor).html","C20H21ClO4","free base","NSC-281319","CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2",5.111,4,0,7]
["S1802","AICAR (Acadesine)","e9","L9900-01","in 10mM DMSO","AMPK,Mitophagy","PI3K/Akt/mTOR","AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3.",258.23,"2627-69-2",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Acadesine.html","C9H14N4O5","free base","NSC105823, AICA Riboside","NC(=O)C1=C(N)[N](C=N1)C2OC(CO)C(O)C2O",-2.913,3,5,3]
["S1831","Carvedilol","f9","L9900-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.",406.47,"72956-09-3",{"v":81,"d":"81.00"},199.28,"<1","N/A","http://selleckchem.com/products/carvedilol.html","C24H26N2O4","free base","BM-14190, SKF 105517","COC1=CC=CC=C1OCCNCC(O)COC2=C3C(=CC=C2)[NH]C4=C3C=CC=C4",4.014,3,3,10]
["S1848","Curcumin","g9","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HCV,HDAC,Histone Acetyltransferase,HIV,Influenza Virus,NF-κB,Nrf2","Epigenetics","Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.",368.38,"458-37-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/Curcumin.html","C21H20O6","free base","Diferuloylmethane, Natural Yellow 3, Turmeric yellow","COC1=CC(=CC=C1O)/C=C/C(O)=C/C(=O)/C=C/C2=CC(=C(O)C=C2)OC",3.573,3,3,7]
["S1899","Nicotinamide (NSC 13128)","h9","L9900-01","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Nicotinamide (Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.",122.12,"98-92-0",{"v":24,"d":"24.00"},196.53,{"v":24,"d":"24.00"},196.53,"http://selleckchem.com/products/Nicotinamide(Niacinamide).html","C6H6N2O","free base","Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128","NC(=O)C1=CC=CN=C1",-0.319,2,1,1]
["S1905","Amlodipine","a10","L9900-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",408.88,"88150-42-9",{"v":82,"d":"82.00"},200.55,"<1","N/A","http://selleckchem.com/products/Amlodipine(Norvasc).html","C20H25ClN2O5","free base","UK-48340","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C",1.576,5,2,10]
["S1937","Isoniazid","b10","L9900-01","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.",137.14,"54-85-3",{"v":27,"d":"27.00"},196.88,{"v":27,"d":"27.00"},196.88,"http://selleckchem.com/products/Isoniazid(Tubizid).html","C6H7N3O","free base","N/A","NNC(=O)C1=CC=NC=C1",-0.811,2,2,1]
["S1949","Menadione (NSC 4170)","c10","L9900-01","in 10mM DMSO","CDK,DNA/RNA Synthesis,phosphatase","Metabolism","Menadione (NSC 4170, Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.",172.18,"58-27-5",{"v":34,"d":"34.00"},197.47,"<1","N/A","http://selleckchem.com/products/Menadione.html","C11H8O2","free base","Vitamin K3,NSC 4170","CC1=CC(=O)C2=CC=CC=C2C1=O",2.204,2,0,0]
["S1950","Metformin HCl","d10","L9900-01","in 10mM DMSO","Autophagy,Carbohydrate Metabolism,JNK,Mitophagy,p38 MAPK","Metabolism","Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",165.62,"1115-70-4",{"v":33,"d":"33.00"},199.25,{"v":33,"d":"33.00"},199.25,"http://selleckchem.com/products/Metformin-hydrochloride(Glucophage).html","C4H11N5.HCl","Hydrochloride","1,1-Dimethylbiguanide HCl","Cl.CN(C)C(=N)NC(N)=N",{"v":-0.36,"d":"-0.360"},0,2,3]
["S1972","Tamoxifen (ICI 46474) Citrate","e10","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Endocrinology & Hormones","Tamoxifen Citrate (Istubal,ICI 46474 Citrate) is a selective estrogen receptor modulator (SERM). Tamoxifen Citrate is also a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis and autophagy.",563.64,"54965-24-1",{"v":100,"d":"100.00"},177.42,"<1","N/A","http://selleckchem.com/products/Tamoxifen-Citrate(Nolvadex).html","C26H29NO.C6H8O7","Citrate","Istubal,ICI 46474 Citrate","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1990","Capsaicin(Vanilloid)","f10","L9900-01","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Capsaicin (Qutenza, Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.",305.41,"404-86-4",{"v":61,"d":"61.00"},199.73,"<1","N/A","http://selleckchem.com/products/capsaicin.html","C18H27NO3","free base","Qutenza, Vanilloid","COC1=C(O)C=CC(=C1)CNC(=O)CCCC\\C=C\\C(C)C",{"v":3.91,"d":"3.910"},2,2,9]
["S1994","Lacidipine","g10","L9900-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure.",455.54,"103890-78-4",{"v":91,"d":"91.00"},199.76,"<1","N/A","http://selleckchem.com/products/lacidipine-lacipil-motens.html","C26H33NO6","free base","GX-1048, GR-43659X, SN-305","CCOC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)\\C=C\\C(=O)OC(C)(C)C)C(=O)OCC)C",3.824,6,1,11]
["S2046","Pioglitazone HCl","h10","L9900-01","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17),PPAR","Metabolism","Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.",{"v":392.9,"d":"392.90"},"112529-15-4",{"v":79,"d":"79.00"},201.07,"<1","N/A","http://selleckchem.com/products/pioglitazone-hydrochloride-actos.html","C19H20N2O3S.HCl","Hydrochloride","AD-4833, U-72107E","Cl.CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",4.289,4,1,7]
["S2055","Gimeracil","a11","L9900-01","in 10mM DMSO","Dehydrogenase","Metabolism","Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.",145.54,"103766-25-2",{"v":29,"d":"29.00"},199.26,"<1","N/A","http://selleckchem.com/products/gimeracil.html","C5H4ClNO2","free base","N/A","OC1=CC(=O)NC=C1Cl",-0.493,1,2,0]
["S2062","Tiopronin","b11","L9900-01","in 10mM DMSO","ROS","Immunology & Inflammation","Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.",163.19,"1953-02-2",{"v":32,"d":"32.00"},196.09,{"v":32,"d":"32.00"},196.09,"http://selleckchem.com/products/tiopronin-thiola.html","C5H9NO3S","free base","N/A","CC(S)C(=O)NCC(O)=O",-0.362,2,1,3]
["S2102","Rasagiline Mesylate","c11","L9900-01","in 10mM DMSO","MAO","Metabolism","Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.",267.34,"161735-79-1",{"v":53,"d":"53.00"},198.25,{"v":53,"d":"53.00"},198.25,"http://selleckchem.com/products/rasagiline-mesylate.html","C12H13N.CH4O3S","Mesylate","TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate","C[S](O)(=O)=O.C#CCNC1CCC2=CC=CC=C12",2.705,0,1,2]
["S2105","Pantoprazole","d11","L9900-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",383.37,"102625-70-7",{"v":76,"d":"76.00"},198.24,"<1","N/A","http://selleckchem.com/products/pantoprazole-protonix.html","C16H15F2N3O4S","free base","SKFSKF96022, BY-1023","COC1=C(OC)C(=NC=C1)C[S](=O)C2=NC3=CC=C(OC(F)F)C=C3[NH]2",2.737,6,1,7]
["S2218","Torkinib (PP242)","e11","L9900-01","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,mTOR","PI3K/Akt/mTOR","Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively. Torkinib (PP242) induces mitophagy and apoptosis.",308.34,"1092351-67-1",{"v":61,"d":"61.00"},197.83,"<1","N/A","http://selleckchem.com/products/PP242.html","C16H16N6O","free base","N/A","CC(C)[N]1N=C(C2=CC3=C([NH]2)C=CC(=C3)O)C4=C(N)N=CN=C14",2.908,3,3,2]
["S2222","PF-3716556","f11","L9900-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.",394.47,"928774-43-0",{"v":79,"d":"79.00"},200.27,"<1","N/A","http://selleckchem.com/products/PF-3716556.html","C22H26N4O3","Free Base","N/A","CN(CCO)C(=O)C1=C[N]2C=C(C)N=C2C(=C1)NC3CCOC4=CC=CC(=C34)C",1.499,3,2,5]
["S2233","Esomeprazole sodium","g11","L9900-01","in 10mM DMSO","ATPase","Transmembrane Transporters","Esomeprazole Sodium((S)-Omeprazole sodium, (-)-Omeprazole sodium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.",{"v":367.4,"d":"367.40"},"161796-78-7",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://selleckchem.com/products/esomeprazole-sodium.html","C17H18N3O3S.Na","Sodium salt","(S)-Omeprazole sodium, (-)-Omeprazole sodium","COC1=CC=C2[N]([Na])C(=NC2=C1)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S2246","Abiraterone Acetate (CB7630)","h11","L9900-01","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Metabolism","Abiraterone Acetate (CB7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.",391.55,"154229-18-2",{"v":20,"d":"20.00"},51.08,"<1","N/A","http://www.selleck.cn/products/Abiraterone-Acetate-CB7630.html","C26H33NO2","Acetate","CB7630, CB-7630","CC(=O)OC1CCC2(C)C3CCC4(C)C(CC=C4C5=CC=CN=C5)C3CC=C2C1",4.602,3,0,3]
["S2250","(-)-Epigallocatechin Gallate","a2","L9900-02","in 10mM DMSO","DNA Methyltransferase,EGFR,Fatty Acid Synthase,HER2,Telomerase","DNA Damage/DNA Repair","(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.",458.37,"989-51-5",{"v":72,"d":"72.00"},157.08,{"v":23,"d":"23.00"},50.18,"http://selleckchem.com/products/(-)-Epigallocatechin-gallate.html","C22H18O11","free base","EGCG","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC(=C(O)C(=C4)O)O)C(=C1)O",3.097,3,8,4]
["S2263","Arbutin","b2","L9900-02","in 10mM DMSO","Tyrosinase","Proteases","Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.",272.25,"497-76-7",{"v":55,"d":"55.00"},202.02,{"v":55,"d":"55.00"},202.02,"http://selleckchem.com/products/Arbutin(Uva,-p-Arbutin).html","C12H16O7","free base","Uva,p-Arbutin, β-Arbutin","OCC1OC(OC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.584,2,5,3]
["S2268","Baicalein","c2","L9900-02","in 10mM DMSO","P450 (e.g. CYP17),PREP","Metabolism","Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.",270.24,"491-67-8",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Baicalein.html","C15H10O5","free base","N/A","OC1=C(O)C(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)O",{"v":2.41,"d":"2.410"},2,3,1]
["S2271","Berberine chloride (NSC 646666)","d2","L9900-02","in 10mM DMSO","Anti-infection,Apoptosis related,Autophagy,Bcl-2,Caspase,IAP,JNK,p38 MAPK,P450 (e.g. CYP17),PARP,ROS,Topoisomerase","Microbiology","Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.",371.81,"633-65-8",{"v":40,"d":"40.00"},107.58,"<1","N/A","http://selleckchem.com/products/Berberine-Hydrochloride.html","C20H18NO4.Cl","chloride","Natural Yellow 18 chloride","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C5OCOC5=C4",1.289,4,0,2]
["S2280","Chlorogenic Acid","e2","L9900-02","in 10mM DMSO","Others","Others","Chlorogenic acid (NSC 407296, Heriguard) is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.",354.31,"327-97-9",{"v":71,"d":"71.00"},200.39,{"v":18,"d":"18.00"},{"v":50.8,"d":"50.80"},"http://selleckchem.com/products/Chlorogenic-acid.html","C16H18O9","free base","NSC 407296, Heriguard","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S2289","Daidzin","f2","L9900-02","in 10mM DMSO","Dehydrogenase","Metabolism","Daidzin (Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside), a natural organic compound in the class of phytochemicals known as isoflavones, is a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase and inhibits ALDH-I selectively (Ki=20 nM); at least 500 times less effective against ALDH-Ⅱ, the cytosolic isozyme (Ki=10 μM).",416.38,"552-66-9",{"v":83,"d":"83.00"},199.34,"<1","N/A","http://selleckchem.com/products/Daidzin.html","C21H20O9","Free Base","Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside","OCC1OC(OC2=CC3=C(C=C2)C(=O)C(=CO3)C4=CC=C(O)C=C4)C(O)C(O)C1O",0.452,4,5,4]
["S2295","Emodin","g2","L9900-02","in 10mM DMSO","Dehydrogenase","Metabolism","Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).",270.24,"518-82-1",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Emodin.html","C15H10O5","free base","N/A","CC1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(O)C=C3O)C2=O",2.568,2,3,0]
["S2296","Enoxolone","h2","L9900-02","in 10mM DMSO","Dehydrogenase","Metabolism","Enoxolone (Glycyrrhetin) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.",470.68,"471-53-4",{"v":94,"d":"94.00"},199.71,"<1","N/A","http://selleckchem.com/products/Enoxolone(Glycyrrhetin).html","C30H46O4","free base","Glycyrrhetin","CC1(C)C(O)CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.656,2,1,1]
["S2300","Ferulic Acid","a3","L9900-02","in 10mM DMSO","FGFR","Angiogenesis","Ferulic Acid (Fumalic) is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong. Ferulic acid is a novel fibroblast growth factor receptor (FGFR) inhibitor with IC50s of 3.78 μM and 12.5 μM for FGFR1 and FGFR2, respectively.",194.19,"1135-24-6",{"v":39,"d":"39.00"},200.83,"<1","N/A","http://selleckchem.com/products/Fumalic-acid(Ferulic-acid).html","C10H10O4","free base","Fumalic Acid","COC1=CC(=CC=C1O)\\C=C\\C(O)=O",1.669,2,1,3]
["S2302","Glycyrrhizin (NSC 167409)","b3","L9900-02","in 10mM DMSO","Dehydrogenase,High-mobility Group,MAO","Metabolism","Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).",822.93,"1405-86-3",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Glycyrrhizic-acid.html","C42H62O16","free base","N/A","CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",2.417,8,5,7]
["S2303","Gossypol Acetate","c3","L9900-02","in 10mM DMSO","Dehydrogenase","Metabolism","Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.",578.61,"12542-36-8",{"v":100,"d":"100.00"},172.83,"<1","N/A","https://www.selleckchem.com/products/gossypol-acetate.html","C32H34O10","Acetate","Gossypol Acetic acid, Pogosin, AT101","CC(C)C1=C2C=C(C)C(=C(O)C2=C(C=O)C(=C1O)O)C3=C(O)C4=C(C=C3C)C(=C(O)C(=C4C=O)O)C(C)C.CC(O)=O",6.388,3,6,5]
["S2305","Grape Seed Extract","d3","L9900-02","in 10mM DMSO","Others","Others","Grape Seed Extract are industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs.","N/A","84929-27-1",{"v":94,"d":"94.00"},{"v":10,"d":"10.00"},"<1","N/A","http://selleckchem.com/products/Grape-Seed-Extract.html","N/A","Polyphenols","N/A","N/A",{"v":0,"d":"0.000"},0,0,0]
["S2309","Hesperidin","e3","L9900-02","in 10mM DMSO","Others","Others","Hesperidin (Cirantin) is a flavanone glycoside found abundantly in citrus fruits.",610.56,"520-26-3",{"v":100,"d":"100.00"},163.78,"<1","N/A","http://selleckchem.com/products/Hesperidin.html","C28H34O15","free base","Cirantin","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",-0.431,7,8,7]
["S2310","Honokiol (NSC 293100)","f3","L9900-02","in 10mM DMSO","Akt,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,HCV,MEK","PI3K/Akt/mTOR","Honokiol (NSC 293100) is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3.",266.33,"35354-74-6",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Honokiol.html","C18H18O2","free base","N/A","OC1=C(CC=C)C=C(C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2314","Kaempferol (NSC 407289)","g3","L9900-02","in 10mM DMSO","Estrogen/progestogen Receptor,Fatty Acid Synthase","Endocrinology & Hormones","Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.",286.23,"520-18-3",{"v":57,"d":"57.00"},199.14,"<1","N/A","http://selleckchem.com/products/Kaempferol.html","C15H10O6","free base","Robigenin","OC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2",1.872,2,4,1]
["S2320","Luteolin","h3","L9900-02","in 10mM DMSO","ADC Cytotoxin,PDE","Metabolism","Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.",286.24,"491-70-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","https://www.selleckchem.com/products/luteolin.html","C15H10O6","free base","Luteoline, Luteolol, Digitoflavone","OC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=C(O)C(=C3)O)O",2.168,2,4,1]
["S2326","Myricetin","a4","L9900-02","in 10mM DMSO","MEK","MAPK","Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.",318.24,"529-44-2",{"v":63,"d":"63.00"},197.96,"<1","N/A","http://selleckchem.com/products/Myricetin(Cannabiscetin).html","C15H10O8","free base","Cannabiscetin","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC(=C(O)C(=C3)O)O)O)O",1.388,2,6,1]
["S2329","Naringin","b4","L9900-02","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.",580.53,"10236-47-2",{"v":100,"d":"100.00"},172.26,"<1","N/A","http://selleckchem.com/products/Naringin(Naringoside).html","C27H32O14","free base","Naringoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C=C5)O)C(O)C(O)C1O",-0.415,6,8,6]
["S2331","Neohesperidin Dihydrochalcone (Nhdc)","c4","L9900-02","in 10mM DMSO","Others","Others","Neohesperidin dihydrochalcone(Nhdc, NCI-c60764), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.",612.58,"20702-77-6",{"v":100,"d":"100.00"},163.24,"<1","N/A","http://selleckchem.com/products/Neohesperidin-dihydrochalcone(Nhdc).html","C28H36O15","free base","NCI-c60764","COC1=C(O)C=C(CCC(=O)C2=C(O)C=C(OC3OC(CO)C(O)C(O)C3OC4OC(C)C(O)C(O)C4O)C=C2O)C=C1",-0.048,6,9,10]
["S2332","Neohesperidin","d4","L9900-02","in 10mM DMSO","ROS","Immunology & Inflammation","Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent., Neohesperidin (NSC 31048) 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。",610.56,"13241-33-3",{"v":122,"d":"122.00"},199.82,"<1","N/A","http://selleckchem.com/products/Neohesperidin.html","C28H34O15","free base","NSC 31048","COC1=CC(=CC(=C1)C2CC(=O)C3=C(O)C=C(OC4OC(CO)C(O)C(O)C4OC5OC(C)C(O)C(O)C5O)C=C3O2)O",-0.431,7,8,7]
["S2333","Nobiletin (NSC 76751)","e4","L9900-02","in 10mM DMSO","MMP","Proteases","Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.",402.39,"478-01-3",{"v":81,"d":"81.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/Nobiletin(Hexamethoxyflavone).html","C21H22O8","free base","Hexamethoxyflavone","COC1=C(OC)C=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.038,8,0,7]
["S2337","Osthole","f4","L9900-02","in 10mM DMSO","Others","Others","Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.",244.29,"484-12-8",{"v":49,"d":"49.00"},200.58,"<1","N/A","http://selleckchem.com/products/Osthole(Osthol).html","C15H16O3","free base","Osthol","COC1=CC=C2C=CC(=O)OC2=C1CC=C(C)C",{"v":3.74,"d":"3.740"},3,0,3]
["S2339","Paeonol","g4","L9900-02","in 10mM DMSO","MAO","Metabolism","Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.",166.17,"552-41-0",{"v":33,"d":"33.00"},198.59,"<1","N/A","http://selleckchem.com/products/Paeonol(Peonol).html","C9H10O3","free base","Peonol","COC1=CC(=C(C=C1)C(C)=O)O",1.311,2,1,2]
["S2341","(-)-Parthenolide","h4","L9900-02","in 10mM DMSO","HDAC,MDM2/MDMX,NF-κB,p53","NF-κB","(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.",248.32,"20554-84-1",{"v":49,"d":"49.00"},197.33,"<1","N/A","http://selleckchem.com/products/Parthenolide((-)-Parthenolide).html","C15H20O3","free base","N/A","CC/1=C\\CCC2(C)OC2C3OC(=O)C(=C)C3CC1",2.923,3,0,0]
["S2343","Phlorizin","a5","L9900-02","in 10mM DMSO","ATPase,SGLT","GPCR & G Protein","Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.",436.41,"60-81-1",{"v":87,"d":"87.00"},199.35,"<1","N/A","http://selleckchem.com/products/Phlorizin(Phloridzin).html","C21H24O10","free base","Phloridzin","OCC1OC(OC2=C(C(=O)CCC3=CC=C(O)C=C3)C(=CC(=C2)O)O)C(O)C(O)C1O",0.827,3,7,7]
["S2348","Rotenone (Barbasco)","b5","L9900-02","in 10mM DMSO","Apoptosis related,Mitochondrial Metabolism,Mitophagy,NADPH-oxidase,ROS","Immunology & Inflammation","Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.",394.42,"83-79-4",{"v":78,"d":"78.00"},197.76,"N/A","N/A","http://selleckchem.com/products/rotenone-barbasco.html","C23H22O6","free base","Barbasco, Dactinol, Paraderil, Rotenon, Rotocide","COC1=CC2=C(C=C1OC)C3C(CO2)OC4=C(C=CC5=C4CC(O5)C(C)=C)C3=O",{"v":3.93,"d":"3.930"},6,0,3]
["S2350","Rutin","c5","L9900-02","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.",610.52,"153-18-4",{"v":100,"d":"100.00"},163.79,"<1","N/A","http://selleckchem.com/products/Rutin(Rutoside).html","C27H30O16","free base","Rutoside","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.158,6,10,6]
["S2358","Silymarin","d5","L9900-02","in 10mM DMSO","Antioxidant","Angiogenesis","Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.",482.44,"65666-07-1",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silymarin(Silybin-B).html","C25H22O10","free base","Silybin B","COC1=CC(=CC=C1O)C2OC3=CC=C(C=C3OC2CO)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O",2.592,5,5,4]
["S2363","Tangeretin","e5","L9900-02","in 10mM DMSO","Antioxidant","Apoptosis","Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.",372.37,"481-53-8",{"v":8,"d":"8.00"},21.48,"<1","N/A","http://selleckchem.com/products/Tangeretin(Tangeritin).html","C20H20O7","free base","Tangeritin","COC1=CC=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.054,7,0,6]
["S2369","Troxerutin","f5","L9900-02","in 10mM DMSO","NLR,ROS","Immunology & Inflammation","Troxerutin, a natural bioflavonoid isolated from Sophora japonica, has been reported to have many benefits and medicinal properties. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.",742.68,"7085-55-4",{"v":100,"d":"100.00"},134.65,{"v":100,"d":"100.00"},134.65,"http://selleckchem.com/products/Troxerutin.html","C33H42O19","free base","N/A","CC1OC(OCC2OC(OC3=C(OC4=CC(=CC(=C4C3=O)O)OCCO)C5=CC(=C(OCCO)C=C5)OCCO)C(O)C(O)C2O)C(O)C(O)C1O",{"v":-2.1,"d":"-2.100"},9,10,15]
["S2370","Ursolic Acid","g5","L9900-02","in 10mM DMSO","Others","Others","Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.",{"v":456.7,"d":"456.70"},"77-52-1",{"v":91,"d":"91.00"},199.26,"<1","N/A","http://selleckchem.com/products/Ursolic-acid(Malol).html","C30H48O3","free base","NSC 167406, NSC-4060, Prunol, Urson, Malol","CC1CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",6.327,1,1,1]
["S2371","Vanillylacetone","h5","L9900-02","in 10mM DMSO","NF-κB","NF-κB","Vanillylacetone (NSC 15335) is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Vanillylacetone (Zingerone) alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.",194.23,"122-48-5",{"v":38,"d":"38.00"},195.64,{"v":10,"d":"10.00"},51.49,"http://selleckchem.com/products/Vanillylacetone.html","C11H14O3","free base","NSC 15335","COC1=CC(=CC=C1O)CCC(C)=O",1.792,2,1,4]
["S2376","Ammonium Glycyrrhizinate","a6","L9900-02","in 10mM DMSO","Dehydrogenase,High-mobility Group","Metabolism","Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.",839.96,"1407-03-0",{"v":168,"d":"168.00"},200.01,{"v":5,"d":"5.00"},5.95,"http://selleckchem.com/products/Ammonium-Glycyrrhizinate(AMGZ).html","C42H62O16.NH3","Glycyrrhizic acid salt","AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt","N.CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",-0.915,8,5,7]
["S2390","Polydatin","b6","L9900-02","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.",390.38,"65914-17-2",{"v":78,"d":"78.00"},199.81,"<1","N/A","http://selleckchem.com/products/Polydatin(Piceid).html","C20H22O8","free base","Piceid","OCC1OC(OC2=CC(=CC(=C2)\\C=C\\C3=CC=C(O)C=C3)O)C(O)C(O)C1O",{"v":1.16,"d":"1.160"},2,6,5]
["S2391","Quercetin (NSC 9221)","c6","L9900-02","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,PI3K,PKC,Sirtuin,Src","Epigenetics","Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.",302.24,"117-39-5",{"v":61,"d":"61.00"},201.83,"<1","N/A","http://selleckchem.com/products/Quercetin(Sophoretin).html","C15H10O7","Free Base","Sophoretin, C.I. 75720","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S2394","Naringenin","d6","L9900-02","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.",272.25,"480-41-1",{"v":54,"d":"54.00"},198.35,"<1","N/A","http://selleckchem.com/products/naringenin.html","C15H12O5","free base","NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol","OC1=CC=C(C=C1)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.373,2,3,1]
["S2396","Salidroside","e6","L9900-02","in 10mM DMSO","Mitophagy,mTOR,PREP","PI3K/Akt/mTOR","Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.",{"v":300.3,"d":"300.30"},"10338-51-9",{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/Salidroside-Rhodioloside.html","C14H20O7","free base","Rhodioloside","OCC1OC(OCCC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.443,2,5,5]
["S2399","Dihydromyricetin","f6","L9900-02","in 10mM DMSO","GABA Receptor,ROS","Neuronal Signaling","Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.",320.25,"27200-12-0",{"v":64,"d":"64.00"},199.84,"<1","N/A","http://selleckchem.com/products/Dihydromyricetin-Ampeloptin.html","C15H12O8","free base","Ampeloptin","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C(=C3)O)O",1.237,2,6,1]
["S2423","(S)-10-Hydroxycamptothecin","g6","L9900-02","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.",364.35,"19685-09-7",{"v":8,"d":"8.00"},21.96,"<1","N/A","http://selleckchem.com/products/10-hydroxycamptothecin.html","C20H16N2O5","free base","10-HCPT","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=CC5=CC(=CC=C5N=C34)O)C2=O",1.504,4,1,1]
["S2425","Apocynin (NSC 2146)","h6","L9900-02","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.",166.17,"498-02-2",{"v":33,"d":"33.00"},198.59,"<1","N/A","http://selleckchem.com/products/apocynin-acetovanillone.html","C9H10O3","free base","Acetovanillone, NSC 209524","COC1=C(O)C=CC(=C1)C(C)=O",1.311,2,1,2]
["S2448","Gambogic Acid","a7","L9900-02","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.",628.75,"2752-65-0",{"v":100,"d":"100.00"},159.05,"<1","N/A","http://selleckchem.com/products/gambogic-acid.html","C38H44O8","free base","Guttatic Acid, Guttic Acid, Beta-Guttiferrin","CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(=C2C=C1)O)C(=O)C4=CC5CC6C(C)(C)OC(C\\C=C(C)/C(O)=O)(C5=O)C46O3",6.957,6,1,8]
["S2485","Mitoxantrone (NSC-301739) 2HCl","b7","L9900-02","in 10mM DMSO","Apoptosis related,COVID-19,PKC,Topoisomerase","DNA Damage/DNA Repair","Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis.",{"v":517.4,"d":"517.40"},"70476-82-3",{"v":89,"d":"89.00"},172.01,{"v":89,"d":"89.00"},172.01,"http://selleckchem.com/products/Mitoxantrone-Hydrochloride.html","C22H29ClN4O6.2HCl","Dihydrochloride","NSC-301739 2HCl","Cl.Cl.OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C3=C(O)C=CC(=C3C2=O)O",0.832,2,8,12]
["S2487","Mycophenolic acid","c7","L9900-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Dehydrogenase,Selection Antibiotics for Transfected Cell","Metabolism","Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.",320.34,"24280-93-1",{"v":64,"d":"64.00"},199.79,"<1","N/A","http://selleckchem.com/products/Mycophenolic-acid(Mycophenolate).html","C17H20O6","free base","Mycophenolate, RS-61443","COC1=C(C)C2=C(C(=C1C\\C=C(/C)CCC(O)=O)O)C(=O)OC2",3.157,4,1,6]
["S2492","Novobiocin Sodium (NSC 2382)","d7","L9900-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase","DNA Damage/DNA Repair","Novobiocin Sodium (NSC 2382, Albamycin, Cathomycin) is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.",634.61,"1476-53-5",{"v":100,"d":"100.00"},157.58,{"v":100,"d":"100.00"},157.58,"http://selleckchem.com/products/Novobiocin-sodium(Albamycin).html","C31H35N2O11.Na","Sodium Salt","Albamycin,Cathomycin,NSC 2382","[Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=C(NC(=O)C4=CC=C([O-])C(=C4)CC=C(C)C)C(=O)OC3=C2C)O)OC1(C)C",2.747,8,4,9]
["S2493","Olanzapine","e7","L9900-02","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.",312.44,"132539-06-1",{"v":62,"d":"62.00"},198.44,"<1","N/A","http://selleckchem.com/products/Olanzapine(Zyprexa).html","C17H20N4S","free base","LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera","CN1CCN(CC1)C2=NC3=C(NC4=C2C=C(C)S4)C=CC=C3",{"v":2.69,"d":"2.690"},1,1,1]
["S2528","Ciclopirox","f7","L9900-02","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator.",207.27,"29342-05-0",{"v":42,"d":"42.00"},202.63,"<1","N/A","http://selleckchem.com/products/Ciclopirox-Penlac.html","C12H17NO2","Free Base","HOE 296b, Penlac","CC1=CC(=O)N(O)C(=C1)C2CCCCC2",2.489,1,0,1]
["S2553","5-Aminolevulinic acid HCl","g7","L9900-02","in 10mM DMSO","Others","Others","5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.",167.59,"5451-09-2",{"v":34,"d":"34.00"},202.88,{"v":34,"d":"34.00"},202.88,"http://selleckchem.com/products/5-Aminolevulinic-acid-hydrochloride.html","C5H9NO3.HCl","Hydrochloride","5-ALA hydrochloride","Cl.NCC(=O)CCC(O)=O",-3.318,2,1,4]
["S2554","Daphnetin","h7","L9900-02","in 10mM DMSO","EGFR,PKA,PKC","Angiogenesis","Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.",178.14,"486-35-1",{"v":35,"d":"35.00"},196.47,"<1","N/A","http://selleckchem.com/products/Daphnetin.html","C9H6O4","free base","N/A","OC1=CC=C2C=CC(=O)OC2=C1O",1.415,2,2,0]
["S2586","Dimethyl Fumarate","a8","L9900-02","in 10mM DMSO","Nrf2","Immunology & Inflammation","Dimethyl fumarate (DMF,Tecfidera,BG-12) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.",144.13,"624-49-7",{"v":29,"d":"29.00"},201.21,"<1","N/A","http://selleckchem.com/products/dimethyl-Fumarate.html","C6H8O4","free base","DMF,Tecfidera,BG-12","COC(=O)\\C=C\\C(=O)OC",{"v":0.49,"d":"0.490"},4,0,4]
["S2605","Idebenone","b8","L9900-02","in 10mM DMSO","ROS","Immunology & Inflammation","Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.",338.44,"58186-27-9",{"v":68,"d":"68.00"},200.92,"<1","N/A","http://selleckchem.com/products/idebenone.html","C19H30O5","free base","CV-2619","COC1=C(OC)C(=O)C(=C(C)C1=O)CCCCCCCCCCO",3.836,4,1,12]
["S2606","Mifepristone (RU486)","c8","L9900-02","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Estrogen/progestogen Receptor,Glucocorticoid Receptor","Endocrinology & Hormones","Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.",429.59,"84371-65-3",{"v":85,"d":"85.00"},197.86,"<1","N/A","http://selleckchem.com/products/Mifepristone(Mifeprex).html","C29H35NO2","free base","RU486, C-1073, RU 38486, RU-486, Mifegyne","CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)C5=CC=C(C=C5)N(C)C",5.655,1,0,3]
["S2610","Lonidamine (AF-1890)","d8","L9900-02","in 10mM DMSO","Carbohydrate Metabolism,Others","Metabolism","Lonidamine (AF 1890, Diclondazolic Acid, DICA) is an orally administered small molecule hexokinase inactivator.",321.16,"50264-69-2",{"v":64,"d":"64.00"},199.28,"<1","N/A","http://selleckchem.com/products/lonidamine.html","C15H10Cl2N2O2","free base","Diclondazolic Acid, DICA","OC(=O)C1=N[N](CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C13",{"v":4.65,"d":"4.650"},2,0,3]
["S2623","Omecamtiv mecarbil (CK-1827452)","e8","L9900-02","in 10mM DMSO","ATPase","Transmembrane Transporters","Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.",401.43,"873697-71-3",{"v":80,"d":"80.00"},199.29,"<1","N/A","http://selleckchem.com/products/Omecamtiv-mecarbil-CK-1827452.html","C20H24FN5O3","free base","N/A","COC(=O)N1CCN(CC1)CC2=CC=CC(=C2F)NC(=O)NC3=CN=C(C)C=C3",1.794,4,2,5]
["S2631","URB597","f8","L9900-02","in 10mM DMSO","FAAH","Metabolism","URB597 (KDS-4103) is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.",{"v":338.4,"d":"338.40"},"546141-08-6",{"v":68,"d":"68.00"},200.95,"<1","N/A","http://selleckchem.com/products/urb597.html","C20H22N2O3","free base","KDS-4103","NC(=O)C1=CC(=CC=C1)C2=CC=CC(=C2)OC(=O)NC3CCCCC3",3.972,3,2,5]
["S2730","Crenolanib (CP-868596)","g8","L9900-02","in 10mM DMSO","FLT3,Mitophagy,PDGFR","Protein Tyrosine Kinase","Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.",443.54,"670220-88-9",{"v":88,"d":"88.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/crenolanib-cp-868596.html","C26H29N5O2","free base","ARO 002","CC1(COC1)COC2=CC3=C(C=C2)[N](C=N3)C4=NC5=C(C=CC=C5C=C4)N6CCC(N)CC6",3.192,4,1,5]
["S2757","Evofosfamide (TH-302)","h8","L9900-02","in 10mM DMSO","Others","Others","Evofosfamide (TH-302) is a selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.",449.04,"918633-87-1",{"v":90,"d":"90.00"},200.43,{"v":10,"d":"10.00"},22.27,"http://selleckchem.com/products/th-302.html","C9H16Br2N5O4P","free base","Evofosfamide","C[N]1C(=CN=C1[N+]([O-])=O)CO[P](=O)(NCCBr)NCCBr",0.537,3,2,10]
["S2776","Devimistat (CPI-613)","a9","L9900-02","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. CPI-613 induces apoptosis in pancreatic cancer cells. Phase 2.",388.59,"95809-78-2",{"v":77,"d":"77.00"},198.15,"<1","N/A","http://selleckchem.com/products/cpi-613.html","C22H28O2S2","free base","N/A","OC(=O)CCCCC(CCSCC1=CC=CC=C1)SCC2=CC=CC=C2",{"v":5.63,"d":"5.630"},1,0,13]
["S2781","RITA (NSC 652287)","b9","L9900-02","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.",292.37,"213261-59-7",{"v":58,"d":"58.00"},198.38,"<1","N/A","http://selleckchem.com/products/rita-nsc-652287.html","C14H12O3S2","free base","N/A","OCC1=CC=C(S1)C2=CC=C(O2)C3=CC=C(CO)S3",3.407,1,2,4]
["S2799","Daporinad","c9","L9900-02","in 10mM DMSO","Autophagy,NAMPT,Transferase","Metabolism","Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.",391.51,"658084-64-1",{"v":78,"d":"78.00"},199.23,"<1","N/A","http://www.selleck.cn/products/apo866-fk866.html","C24H29N3O2","Free Base","FK866, APO866","O=C(NCCCCC1CCN(CC1)C(=O)C2=CC=CC=C2)/C=C/C3=CC=CN=C3",3.269,3,1,8]
["S2803","Galeterone","d9","L9900-02","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Endocrinology & Hormones","Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.",388.55,"851983-85-2",{"v":24,"d":"24.00"},61.77,"<1","N/A","http://selleckchem.com/products/galeterone-tok-001.html","C26H32N2O","free base","TOK-001","CC12CCC(O)CC1=CCC3C2CCC4(C)C3CC=C4[N]5C=NC6=C5C=CC=C6",4.897,1,1,1]
["S2812","(R)-(-)-Gossypol acetic acid","e9","L9900-02","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2","Apoptosis","(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.",578.61,"866541-93-7",{"v":116,"d":"116.00"},200.48,"<1","N/A","https://www.selleckchem.com/products/at101-acetic-acid.html","C30H30O8.C2H4O2","free base","AT-101 acetic acid, (-)-Gossypol acetic acid, (R)-Gossypol acetic acid","CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(C)C=C4C(=C(O)C(=C(C=O)C4=C3O)O)C(C)C)O.CC(O)=O",6.388,3,6,5]
["S2843","BI-D1870","f9","L9900-02","in 10mM DMSO","Autophagy,ROS,S6 Kinase","PI3K/Akt/mTOR","BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.",391.42,"501437-28-1",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/bi-d1870.html","C19H23F2N5O2","free base","N/A","CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2",4.069,3,2,5]
["S2910","Tempol","g9","L9900-02","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.",172.24,"2226-96-2",{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},"http://selleckchem.com/products/tempol-4-hydroxy-tempo.html","C9H18NO2","free base","4-Hydroxy-TEMPO","CC1(C)CC(O)CC(C)(C)N1[O]",0.413,0,1,0]
["S2929","Pifithrin-α (PFTα) HBr","h9","L9900-02","in 10mM DMSO","AhR,Autophagy,p53","Apoptosis","Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).",{"v":367.3,"d":"367.30"},"63208-82-2",{"v":67,"d":"67.00"},182.41,"<1","N/A","http://selleckchem.com/products/pifithrin-alpha.html","C16H18N2OS.HBr","HBr","Pifithrin-α hydrobromide","Br.CC1=CC=C(C=C1)C(=O)CN2C(=N)SC3=C2CCCC3",3.993,1,0,3]
["S2930","Pifithrin-μ","a10","L9900-02","in 10mM DMSO","Autophagy,HSP (HSP90),p53","Apoptosis","Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.",181.21,"64984-31-2",{"v":36,"d":"36.00"},198.66,"<1","N/A","http://selleckchem.com/products/pifithrin-u.html","C8H7NO2S","free base","NSC 303580, PFTμ, 2-Phenylethynesulfonamide","N[S](=O)(=O)C#CC1=CC=CC=C1",0.825,2,1,2]
["S3017","Aspirin (NSC 27223)","b10","L9900-02","in 10mM DMSO","Autophagy,COX,Mitophagy","Metabolism","Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.",180.16,"50-78-2",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/aspirin-acetylsalicylic-acid.html","C9H8O4","free base","Acetylsalicylic acid, ASA","CC(=O)OC1=C(C=CC=C1)C(O)=O",1.227,3,0,3]
["S3019","Ciclopirox ethanolamine","c10","L9900-02","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296,Ciclopiroxolamine) is a broad-spectrum antifungal agent working as an iron chelator.",268.35,"41621-49-2",{"v":6,"d":"6.00"},22.36,"<1","N/A","http://selleckchem.com/products/ciclopirox-ethanolamine.html","C12H17NO2.C2H7NO","Ethanolamine","Ciclopirox olamine, HOE 296,Ciclopiroxolamine","CC1=CC(=O)N(O)C(=C1)C2CCCCC2.NCCO",1.302,1,2,2]
["S3046","Azilsartan","d10","L9900-02","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.",456.45,"147403-03-0",{"v":91,"d":"91.00"},199.36,"<1","N/A","http://selleckchem.com/products/azilsartan-tak-536.html","C25H20N4O5","free base","TAK-536","CCOC1=NC2=CC=CC(=C2[N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(O)=O",4.662,6,1,7]
["S3114","Vitamin C","e10","L9900-02","in 10mM DMSO","Vitamin","Metabolism","Vitamin C (L-Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.",176.12,"50-81-7",{"v":35,"d":"35.00"},198.73,{"v":35,"d":"35.00"},198.73,"http://selleckchem.com/products/vitamin-c-ascorbic-acid.html","C6H8O6","free base","L-Ascorbic acid","OCC(O)C1OC(=O)C(=C1O)O",-1.709,2,4,2]
["S3124","Dexamethasone Acetate","f10","L9900-02","in 10mM DMSO","Complement System,COVID-19,IL Receptor","Immunology & Inflammation","Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":434.5,"d":"434.50"},"1177-87-3",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/dexamethasone-acetate.html","C24H31FO6","free base","NSC 39471,Dexamethasone 21-acetate","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COC(C)=O",2.087,4,1,4]
["S3212","Moclobemide (Ro 111163)","g10","L9900-02","in 10mM DMSO","MAO","Metabolism","Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.",268.74,"71320-77-9",{"v":53,"d":"53.00"},197.22,"<1","N/A","http://selleckchem.com/products/moclobemide.html","C13H17ClN2O2","free base","N/A","ClC1=CC=C(C=C1)C(=O)NCCN2CCOCC2",1.528,2,1,4]
["S3600","Schisandrin B (Sch B)","h10","L9900-02","in 10mM DMSO","ATM/ATR,P-gp","PI3K/Akt/mTOR","Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.",400.46,"61281-37-6",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://selleckchem.com/products/schisandrin-b.html","C23H28O6","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C4OCOC4=C3OC",5.067,6,0,4]
["S3603","Betulinic acid","a11","L9900-02","in 10mM DMSO","NF-κB,Topoisomerase","DNA Damage/DNA Repair","Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Betulinic acid acts as a new activator of NF-kB.Phase 1/2.",{"v":456.7,"d":"456.70"},"472-15-1",{"v":20,"d":"20.00"},43.79,"<1","N/A","http://selleckchem.com/products/betulinic-acid.html","C30H48O3","free base","ALS-357, Lupatic acid, Betulic acid","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12)C(O)=O",6.546,1,1,2]
["S3612","Rosmarinic acid","b11","L9900-02","in 10mM DMSO","Complement System,IκB/IKK","NF-κB","Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.",360.31,"20283-92-5",{"v":72,"d":"72.00"},199.83,{"v":24,"d":"24.00"},66.61,"http://selleckchem.com/products/rosmarinic-acid.html","C18H16O8","free base","Rosemary acid","OC(=O)C(CC1=CC=C(O)C(=C1)O)OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O",2.706,3,4,7]
["S3616","Asiaticoside","c11","L9900-02","in 10mM DMSO","ROS","Immunology & Inflammation","Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.",959.12,"16830-15-2",{"v":100,"d":"100.00"},104.26,"<1","N/A","http://selleckchem.com/products/asiaticoside.html","C48H78O19","free base","Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O",-0.101,7,12,10]
["S3628","BHQ","d11","L9900-02","in 10mM DMSO","ADC Cytotoxin,ATPase","Transmembrane Transporters","BHQ (2,5-di-t-butyl-1,4-benzohydroquinone) is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).",222.32,"88-58-4",{"v":10,"d":"10.00"},44.98,"<1","N/A","http://selleckchem.com/products/bhq.html","C14H22O2","free base","2,5-di-t-butyl-1,4-benzohydroquinone","CC(C)(C)C1=C(O)C=C(C(=C1)O)C(C)(C)C",4.146,0,2,2]
["S3630","Methyl Vanillate","e11","L9900-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.",182.17,"3943-74-6",{"v":36,"d":"36.00"},197.62,{"v":12,"d":"12.00"},65.87,"http://selleckchem.com/products/methyl-vanillate.html","C9H10O4","free base","N/A","COC(=O)C1=CC(=C(O)C=C1)OC",1.426,3,1,3]
["S3643","Amitraz","f11","L9900-02","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Amitraz (NSC 324552) is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.",293.41,"33089-61-1",{"v":58,"d":"58.00"},197.68,"<1","N/A","http://selleckchem.com/products/amitraz.html","C19H23N3","free base","NSC 324552","CN(C=NC1=CC=C(C)C=C1C)C=NC2=CC=C(C)C=C2C",4.825,2,0,4]
["S3652","3-Nitropropionic acid","g11","L9900-02","in 10mM DMSO","Dehydrogenase","Metabolism","3-Nitropropionic acid (β-Nitropropionic Acid, 3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.",119.08,"504-88-1",{"v":23,"d":"23.00"},193.15,{"v":23,"d":"23.00"},193.15,"http://selleckchem.com/products/3-nitropropionic-acid.html","C3H5NO4","free base","β-Nitropropionic Acid, 3-NP","OC(=O)CC[N+]([O-])=O",{"v":0.02,"d":"0.020"},1,0,3]
["S3654","Tauroursodeoxycholic Acid (TUDCA)","h11","L9900-02","in 10mM DMSO","Mitochondrial Metabolism","Neuronal Signaling","Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).",{"v":499.7,"d":"499.70"},"14605-22-2",{"v":99,"d":"99.00"},198.12,{"v":30,"d":"30.00"},60.04,"http://selleckchem.com/products/tauroursodeoxycholic-acid.html","C26H45NO6S","free base","N/A","CC(CCC(=O)NCC[S](O)(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",2.997,1,3,7]
["S3658","O6-Benzylguanine","a2","L9900-03","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.",241.25,"19916-73-5",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/o6-benzylguanine.html","C12H11N5O","free base","O6-BG","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3=CC=CC=C3",1.646,4,2,3]
["S3660","Uniconazole (S 3307D)","b2","L9900-03","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Uniconazole (S 3307D, XE 1019D) is a well known inhibitor of cytochrome P450 monooxygenase that prevents the biosynthesis of trans-zeatin. Uniconazole targets CYP735As with Ki of 22 μM.",291.78,"83657-22-1",{"v":58,"d":"58.00"},198.78,"<1","N/A","http://selleckchem.com/products/uniconazole.html","C15H18ClN3O","free base","XE 1019D","CC(C)(C)C(O)C(=C/C1=CC=C(Cl)C=C1)\\[N]2C=NC=N2",3.098,2,1,4]
["S3665","Trolox","c2","L9900-03","in 10mM DMSO","Vitamin","Metabolism","Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties.",250.29,"53188-07-1",{"v":50,"d":"50.00"},199.77,"<1","N/A","http://selleckchem.com/products/trolox.html","C14H18O4","free base","N/A","CC1=C(C)C2=C(CCC(C)(O2)C(O)=O)C(=C1O)C",3.489,2,1,1]
["S3666","Ilaprazole","d2","L9900-03","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Ilaprazole (IY-81149) is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.",366.44,"172152-36-2",{"v":73,"d":"73.00"},199.21,"<1","N/A","http://selleckchem.com/products/ilaprazole.html","C19H18N4O2S","free base","IY-81149","COC1=CC=NC(=C1C)C[S](=O)C2=NC3=C([NH]2)C=C(C=C3)[N]4C=CC=C4",3.311,4,1,5]
["S3690","Pargyline hydrochloride","e2","L9900-03","in 10mM DMSO","MAO","Metabolism","Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.",195.69,"306-07-0",{"v":39,"d":"39.00"},199.29,{"v":39,"d":"39.00"},199.29,"http://selleckchem.com/products/pargyline-hydrochloride.html","C11H13N.HCl","hydrochloride","Pargylamine hydrochloride","Cl.CN(CC#C)CC1=CC=CC=C1",3.477,0,0,3]
["S3694","Glucosamine hydrochloride","f2","L9900-03","in 10mM DMSO","Others","Immunology & Inflammation","Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.",215.63,"66-84-2",{"v":4,"d":"4.00"},18.55,{"v":43,"d":"43.00"},199.42,"http://selleckchem.com/products/glucosamine-hydrochloride.html","C6H13NO5.HCl","hydrochloride","2-Amino-2-deoxy-glucose HCl, Chitosamine HCl","Cl.NC1C(O)OC(CO)C(O)C1O",-2.422,1,4,1]
["S3695","Cystamine dihydrochloride","g2","L9900-03","in 10mM DMSO","Anti-infection","Microbiology","Cystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.",{"v":225.2,"d":"225.20"},"56-17-7",{"v":14,"d":"14.00"},62.17,{"v":45,"d":"45.00"},199.82,"http://selleckchem.com/products/cystamine-dihydrochloride.html","C4H12N2S2.2HCl","dihydrochloride","Decarboxycystine dihydrochloride, 2-Aminoethyl disulfide dihydrochloride, 2,2'-Dithiobisethanamine dihydrochloride","Cl.Cl.NCCSSCCN",0.491,0,2,5]
["S3722","Isavuconazole","h2","L9900-03","in 10mM DMSO","Fungal","Microbiology","Isavuconazole (BAL-4815, RO-0094815) is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi that inhibits cytochrome P450 (CYP)-dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis.",437.47,"241479-67-4",{"v":87,"d":"87.00"},198.87,"<1","N/A","http://selleckchem.com/products/isavuconazole.html","C22H17F2N5OS","free base","BAL-4815, RO-0094815","CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(O)(C[N]3C=NC=N3)C4=CC(=CC=C4F)F",3.904,3,0,6]
["S3729","Iron sucrose","a3","L9900-03","in 10mM DMSO","Others","Others","Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.",736.06,"8047-67-4",{"v":100,"d":"100.00"},135.86,{"v":100,"d":"100.00"},135.86,"http://selleckchem.com/products/iron-sucrose.html","C18H24Fe2O24","Iron saccharate","Iron saccharate, Sucroferric oxyhydroxide","[Fe+3].[Fe+3].OC(C(O)C(O)C([O-])=O)C(O)C([O-])=O.OC(C(O)C(O)C([O-])=O)C(O)C([O-])=O.OC(C(O)C(O)C([O-])=O)C(O)C([O-])=O",-16.899,0,12,15]
["S3765","Picroside II","b3","L9900-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.",512.46,"39012-20-9",{"v":100,"d":"100.00"},195.14,"N/A","N/A","http://selleckchem.com/products/picroside-ii.html","C23H28O13","free base","6-Vanilloylcatalpol, Vanilloyl catalpol","COC1=CC(=CC=C1O)C(=O)OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C5(CO)OC25",-1.796,7,6,8]
["S3783","Echinacoside","c3","L9900-03","in 10mM DMSO","Tyrosinase","Protein Tyrosine Kinase","Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside also has a remarkable antiosteoporotic activity.",786.73,"82854-37-3",{"v":100,"d":"100.00"},127.11,"N/A","N/A","http://selleckchem.com/products/echinacoside.html","C35H46O20","free base","N/A","CC1OC(OC2C(O)C(OCCC3=CC(=C(O)C=C3)O)OC(COC4OC(CO)C(O)C(O)C4O)C2OC(=O)\\C=C\\C5=CC=C(O)C(=C5)O)C(O)C(O)C1O",-1.263,8,12,14]
["S3786","Glabridin","d3","L9900-03","in 10mM DMSO","GABA Receptor,PPAR","Metabolism","Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.",324.37,"59870-68-7",{"v":64,"d":"64.00"},197.31,"N/A","N/A","http://selleckchem.com/products/glabridin.html","C20H20O4","free base","Q-100692, KB-289522, LS-176045","CC1(C)OC2=C(C=C1)C3=C(CC(CO3)C4=CC=C(O)C=C4O)C=C2",3.999,2,2,1]
["S3790","Methyl gallate","e3","L9900-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.",184.15,"99-24-1",{"v":36,"d":"36.00"},359.57,"N/A","N/A","http://selleckchem.com/products/methyl-gallate.html","C8H8O5","free base","Methylgallate, Gallic acid methyl ester, Gallicin","COC(=O)C1=CC(=C(O)C(=C1)O)O",0.959,2,3,2]
["S3791","Succinic acid","f3","L9900-03","in 10mM DMSO","Others","Metabolism","Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.",118.09,"110-15-6",{"v":23,"d":"23.00"},194.77,"N/A","N/A","http://selleckchem.com/products/succinic-acid.html","C4H6O4","free base","1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid","OC(=O)CCC(O)=O",{"v":-0.36,"d":"-0.360"},2,0,3]
["S3804","Alpha-Mangostin","g3","L9900-03","in 10mM DMSO","Dehydrogenase,STING","Metabolism","Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities.    alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.",410.46,"6147-11-1",{"v":82,"d":"82.00"},199.78,"N/A","N/A","http://selleckchem.com/products/alpha-mangostin.html","C24H26O6","free base","N/A","COC1=C(O)C=C2OC3=C(C(=C(CC=C(C)C)C(=C3)O)O)C(=O)C2=C1CC=C(C)C",5.935,3,3,5]
["S3815","Mogroside V","h3","L9900-03","in 10mM DMSO","Others","Others","Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).",1287.43,"88901-36-4",{"v":100,"d":"100.00"},77.67,"N/A","N/A","http://selleckchem.com/products/mogroside-v.html","C60H102O29","free base","N/A","CC(CCC(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1OC3OC(CO)C(O)C(O)C3O)C(C)(C)O)C4CCC5(C)C6CC=C7C(CCC(OC8OC(COC9OC(CO)C(O)C(O)C9O)C(O)C(O)C8O)C7(C)C)C6(C)C(O)CC45C",{"v":-3.98,"d":"-3.980"},10,18,20]
["S3816","Dehydroevodiamine","a4","L9900-03","in 10mM DMSO","COX,NF-κB,PGES,ROS","Immunology & Inflammation","Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.",301.34,"67909-49-3",{"v":19,"d":"19.00"},63.05,"N/A","N/A","http://selleckchem.com/products/dehydroevodiamine.html","C19H15N3O","inner salt","DHED","C[N+]1=C2N(CCC3=C2[N-]C4=C3C=CC=C4)C(=O)C5=C1C=CC=C5",3.186,1,0,0]
["S3817","Harmine hydrochloride","b4","L9900-03","in 10mM DMSO","5-HT Receptor,ADC Cytotoxin,DYRK,MAO","Cell Cycle","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",248.71,"343-27-1",{"v":21,"d":"21.00"},84.44,"N/A","N/A","http://selleckchem.com/products/harmine-hydrochloride.html","C13H12N2O.HCl","hydrochloride","Telepathine hydrochloride","Cl.COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",{"v":2.82,"d":"2.820"},2,1,1]
["S3824","Quercitrin","c4","L9900-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.",448.38,"522-12-3",{"v":89,"d":"89.00"},198.49,"N/A","N/A","http://selleckchem.com/products/quercitrin.html","C21H20O11","free base","3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine","CC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",0.589,4,7,3]
["S3826","Hydroxytyrosol","d4","L9900-03","in 10mM DMSO","Others","Others","Hydroxytyrosol (3,4-dihydroxyphenylethanol) is one of the main phenolic components of olive oil with excellent antioxidant, antimicrobial and anticarcinogenic activities.",154.16,"10597-60-1",{"v":30,"d":"30.00"},{"v":194.6,"d":"194.60"},"N/A","N/A","http://selleckchem.com/products/hydroxytyrosol.html","C8H10O3","free base","3-Hydroxytyrosol; 3,4-dihydroxyphenylethanol; Dihydroxyphenylethanol; 2-(3,4-Di-hydroxyphenyl)-ethanol","OCCC1=CC=C(O)C(=C1)O",1.062,0,3,2]
["S3832","Euphorbiasteroid","e4","L9900-03","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Euphorbiasteroid (Euphorbia factor L1), a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells through activation of the AMPK pathway and induces HL-60 cells to apoptosis via promoting Bcl-2/Bax apoptotic signaling pathway in a dose-dependent manner. Euphorbiasteroid is a tricyclic diperpene of Euphorbia lathyris L., inhibits tyrosinase, and increases the phosphorylation of AMPK, with anti-cancer, anti-virus, anti-obesity and multidrug resistance-modulating effect.",552.66,"28649-59-4",{"v":21,"d":"21.00"},{"v":38,"d":"38.00"},"N/A","N/A","http://selleckchem.com/products/euphorbiasteroid.html","C32H40O8","free base","Euphorbia factor L1","CC1CC2(OC(C)=O)C(C1OC(=O)CC3=CC=CC=C3)C(OC(C)=O)C4(CCC5C(\\C=C(C)\\C2=O)C5(C)C)CO4",4.183,8,0,8]
["S3833","Amentoflavone","f4","L9900-03","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.",538.46,"1617-53-4",{"v":100,"d":"100.00"},185.71,"N/A","N/A","http://selleckchem.com/products/amentoflavone.html","C30H18O10","free base","Didemethyl Ginkgetin","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(O)C=C3O)C4=CC(=CC=C4O)C5=CC(=O)C6=C(O5)C=C(O)C=C6O",4.509,4,6,3]
["S3834","Astaxanthin","g4","L9900-03","in 10mM DMSO","PPAR","Metabolism","Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.",596.84,"472-61-7",{"v":100,"d":"100.00"},167.55,"N/A","N/A","http://selleckchem.com/products/astaxanthin.html","C40H52O4","free base","β-Carotene-4,4'-dione, Trans-Astaxanthin","CC(=C\\C=C\\C=C(C)\\C=C\\C=C(C)\\C=C\\C1=C(C)C(=O)C(O)CC1(C)C)/C=C/C=C(C)/C=C/C2=C(C)C(=O)C(O)CC2(C)C",8.421,2,2,10]
["S3837","Echinocystic acid","h4","L9900-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.",{"v":472.7,"d":"472.70"},"510-30-5",{"v":94,"d":"94.00"},198.86,"N/A","N/A","http://selleckchem.com/products/echinocystic-acid.html","C30H48O4","free base","N/A","CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",5.345,1,2,1]
["S3838","Carnosic acid","a5","L9900-03","in 10mM DMSO","ROS","Immunology & Inflammation","Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.",332.43,"3650-09-7",{"v":66,"d":"66.00"},198.54,"N/A","N/A","http://selleckchem.com/products/carnosic-acid.html","C20H28O4","free base","Salvin","CC(C)C1=CC2=C(C(=C1O)O)C3(CCCC(C)(C)C3CC2)C(O)=O",4.905,1,2,2]
["S3839","1-Deoxynojirimycin","b5","L9900-03","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.",163.17,"19130-96-2",{"v":16,"d":"16.00"},98.06,"N/A","N/A","http://selleckchem.com/products/1-deoxynojirimycin.html","C6H13NO4","free base","duvoglustat, moranolin","OCC1NCC(O)C(O)C1O",{"v":-2.44,"d":"-2.440"},0,5,1]
["S3840","Baohuoside I","c5","L9900-03","in 10mM DMSO","ROS","Immunology & Inflammation","Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.",514.52,"113558-15-9",{"v":100,"d":"100.00"},194.36,"N/A","N/A","http://selleckchem.com/products/baohuoside-i.html","C27H30O10","Flavonoid glycoside","Icariside II","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O)C=C(O)C(=C4O2)CC=C(C)C",2.913,5,5,6]
["S3842","Isoquercitrin","d5","L9900-03","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.",464.38,"482-35-9",{"v":92,"d":"92.00"},198.11,"N/A","N/A","http://selleckchem.com/products/isoquercitrin.html","C21H20O12","free base","Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside","OCC1OC(OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S3850","Glucosamine sulfate","e5","L9900-03","in 10mM DMSO","Others","Others","Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid.",277.25,"29031-19-4",{"v":4,"d":"4.00"},14.43,{"v":55,"d":"55.00"},198.38,"http://selleckchem.com/products/glucosamine-sulfate.html","C6H13NO5.H2SO4","sulfate","D-Glucosaminesulfate, D-Glucosamine sulphate","NC(C=O)C(O)C(O)C(O)CO.O[S](O)(=O)=O",-3.688,1,5,5]
["S3855","Ethyl ferulate","f5","L9900-03","in 10mM DMSO","Others","Others","Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.",222.24,"4046-02-0",{"v":44,"d":"44.00"},197.98,"N/A","N/A","http://selleckchem.com/products/ethyl-ferulate.html","C12H14O4","free base","Ferulic acid ethyl ester, Ethyl 4'-hydroxy-3'-methoxycinnamate, Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate","CCOC(=O)/C=C/C1=CC(=C(O)C=C1)OC",2.243,3,1,5]
["S3868","Harmine","g5","L9900-03","in 10mM DMSO","MAO,PPAR","Metabolism","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",212.25,"442-51-3",{"v":42,"d":"42.00"},197.88,"N/A","N/A","http://selleckchem.com/products/harmine.html","C13H12N2O","free base","Telepathine","COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",2.438,2,1,1]
["S3869","Methyl protocatechuate","h5","L9900-03","in 10mM DMSO","Others","Others","Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.",168.15,"2150-43-8",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/methyl-protocatechuate.html","C8H8O4","free base","Methyl 3,4-dihydroxybenzoate; 3,4-Dihydroxybenzoic acid methyl ester; Protocatechuic Acid Methyl Ester","COC(=O)C1=CC(=C(O)C=C1)O",1.201,2,2,2]
["S3883","Protopine","a6","L9900-03","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.",353.37,"130-86-9",{"v":30,"d":"30.00"},{"v":84.9,"d":"84.90"},"N/A","N/A","http://selleckchem.com/products/protopine.html","C20H19NO5","free base","Corydinine, Fumarine, Biflorine, Macleyine","CN1CCC2=C(C=C3OCOC3=C2)C(=O)CC4=C(C1)C5=C(OCO5)C=C4",2.953,5,0,0]
["S3885","Pyrogallol","b6","L9900-03","in 10mM DMSO","ROS","Immunology & Inflammation","Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.",126.11,"87-66-1",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/pyrogallol.html","C6H6O3","free base","1,2,3-trihydroxybenzene","OC1=C(O)C(=CC=C1)O",1.103,0,3,0]
["S3905","Iso-Steviol","c6","L9900-03","in 10mM DMSO","Others","Others","Isosteviol (ISV) is mainly obtained by acid hydrolysis of stevioside, the sweet food additive extracted from the plant Stevia Rebaudiana Bertoni (Bertoni). It possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant effects.",318.45,"27975-19-5",{"v":63,"d":"63.00"},197.83,"N/A","N/A","http://selleckchem.com/products/iso-steviol.html","C20H30O3","free base","N/A","CC12CCC3C4(C)CCCC(C)(C4CCC3(CC1=O)C2)C(O)=O",3.924,2,0,1]
["S3924","Ginsenoside Rb1","d6","L9900-03","in 10mM DMSO","ATPase,IFN,IRAK,NF-κB,NOS,TLR,TNF-alpha","Transmembrane Transporters","Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.",1109.29,"41753-43-9",{"v":100,"d":"100.00"},90.15,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rb1.html","C54H92O23","free base","Gypenoside Ⅲ","CC(C)=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C",-1.198,8,15,16]
["S3925","(-)-Epicatechin gallate","e6","L9900-03","in 10mM DMSO","COX","Immunology & Inflammation","(-)-Epicatechin gallate (ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.",442.37,"1257-08-5",{"v":88,"d":"88.00"},198.93,"N/A","N/A","http://selleckchem.com/products/epicatechin-gallate.html","C22H18O10","free base","(−)-ECG, (−)-Epicatechin 3-gallate, (−)-Epicatechin-3-O-gallate","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC=C(O)C(=C4)O)C(=C1)O",3.339,3,7,4]
["S3930","Liquiritin","f6","L9900-03","in 10mM DMSO","AKR1C","Immunology & Inflammation","Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.",418.39,"551-15-5",{"v":100,"d":"100.00"},239.01,"N/A","N/A","http://selleckchem.com/products/liquiritin.html","C21H22O9","free base","Liquiritoside, Liquiritigenin-4'-O-glucoside","OCC1OC(OC2=CC=C(C=C2)C3CC(=O)C4=C(O3)C=C(O)C=C4)C(O)C(O)C1O",0.686,4,5,4]
["S3937","Pterostilbene","g6","L9900-03","in 10mM DMSO","Others","Others","Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.",{"v":256.3,"d":"256.30"},"537-42-8",{"v":51,"d":"51.00"},198.99,"<1","N/A","https://www.selleckchem.com/products/pterostilbene.html","C16H16O3","free base","N/A","COC1=CC(=CC(=C1)\\C=C\\C2=CC=C(O)C=C2)OC",3.541,2,1,4]
["S3941","Pinocembrin","h6","L9900-03","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.",256.25,"480-39-7",{"v":51,"d":"51.00"},199.02,"<1","N/A","http://selleckchem.com/products/pinocembrin.html","C15H12O4","free base","Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone","OC1=CC2=C(C(=O)CC(O2)C3=CC=CC=C3)C(=C1)O",2.615,2,2,1]
["S3944","Valproic acid (VPA)","a7","L9900-03","in 10mM DMSO","Autophagy,HDAC,Mitophagy,Notch,PGC-1α","Epigenetics","Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.",144.21,"99-66-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/valproic-acid.html","C8H16O2","free base","2-Propylvaleric Acid, Valproate","CCCC(CCC)C(O)=O",2.749,1,0,5]
["S3957","Gamma-Oryzanol","b7","L9900-03","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.  γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).",602.89,"11042-64-1",{"v":100,"d":"100.00"},165.87,"N/A","N/A","http://selleckchem.com/products/gamma-oryzanol.html","C40H58O4","free base","N/A","COC1=CC(=CC=C1O)/C=C/C(=O)OC2CCC34CC35CCC6(C)C(CCC6(C)C5CCC4C2(C)C)C(C)CCC=C(C)C",9.806,3,1,9]
["S3969","Veratric acid","c7","L9900-03","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,PGES","Immunology & Inflammation","Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.",182.17,"93-07-2",{"v":36,"d":"36.00"},197.62,"N/A","N/A","http://selleckchem.com/products/veratric-acid.html","C9H10O4","free base","3,4-Dimethoxybenzoic acid","COC1=C(OC)C=C(C=C1)C(O)=O",1.426,3,0,3]
["S3981","Sinapinic Acid","d7","L9900-03","in 10mM DMSO","ACE,HDAC","DNA Damage/DNA Repair","Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.",224.21,"530-59-6",{"v":44,"d":"44.00"},196.24,"<1","N/A","http://selleckchem.com/products/sinapinic-acid.html","C11H12O5","free base","Sinapic acid","COC1=C(O)C(=CC(=C1)\\C=C\\C(O)=O)OC",1.652,3,1,4]
["S3993","Ethyl Vanillate","e7","L9900-03","in 10mM DMSO","Dehydrogenase","Metabolism","Ethyl vanillin (Bourbonal, Ethylprotal), a vanillin analog, is a flavouring agent and a fungicidal agent that exhibits strong antioxidant activity. Ethyl Vanillate inhibits 17β-HSD2 with an IC50 1.3 µM.",{"v":196.2,"d":"196.20"},"617-05-0",{"v":39,"d":"39.00"},198.78,"N/A","N/A","http://selleckchem.com/products/ethylvanillate.html","C10H12O4","free base","Bourbonal, Ethylprotal","CCOC(=O)C1=CC(=C(O)C=C1)OC",1.775,3,1,4]
["S3998","(+)-α-Lipoic acid","f7","L9900-03","in 10mM DMSO","LTR,NF-κB","NF-κB","(+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. R(+)-α-lipoic acid is an essential cofactor of mitochondrial enzyme complexes. R(+)-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation.",206.33,"1200-22-2",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/alpha-lipoic-acid.html","C8H14O2S2","free base","(R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S4007","Pentamidine isethionate","g7","L9900-03","in 10mM DMSO","phosphatase","Metabolism","Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.",592.68,"140-64-7",{"v":100,"d":"100.00"},168.73,{"v":100,"d":"100.00"},168.73,"http://selleckchem.com/products/pentamidine-isethionate.html","C19H24N4O2.2C2H6O4S","isethionate","N/A","NC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1.OCC[S](O)(=O)=O.OCC[S](O)(=O)=O",0.751,2,4,14]
["S4017","Allylthiourea","h7","L9900-03","in 10mM DMSO","ROS","Immunology & Inflammation","Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.",116.18,"109-57-9",{"v":23,"d":"23.00"},197.97,"<1","N/A","http://selleckchem.com/products/allylthiourea.html","C4H8N2S","free base","N/A","NC(=S)NCC=C",0.842,0,2,3]
["S4099","Dexlansoprazole","a8","L9900-03","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole), the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H(+),K(+)-ATPase proton pump in the gastric parietal cell.",369.36,"138530-94-6",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/dexlansoprazole.html","C16H14F3N3O2S","free base","T 168390, TAK 390,(R)-Lansoprazole","CC1=C(C[S](=O)C2=NC3=C([NH]2)C=CC=C3)N=CC=C1OCC(F)(F)F",3.442,4,1,6]
["S4100","Esmolol HCl","b8","L9900-03","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Esmolol (ASL8052) is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.",331.83,"81161-17-3",{"v":66,"d":"66.00"},{"v":198.9,"d":"198.90"},{"v":66,"d":"66.00"},{"v":198.9,"d":"198.90"},"http://selleckchem.com/products/esmolol-hcl.html","C16H25NO4.HCl","Hydrochloride","ASL8052","Cl.COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1",{"v":2.36,"d":"2.360"},3,2,10]
["S4104","Diminazene Aceturate","c8","L9900-03","in 10mM DMSO","ACE,Parasite","Microbiology","Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent.  The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.",515.52,"908-54-3",{"v":19,"d":"19.00"},36.86,{"v":100,"d":"100.00"},193.98,"http://selleckchem.com/products/diminazene-aceturate.html","C14H15N7.2C4H7NO3","Aceturate","Diminazene diaceturate","CC(=O)NCC(O)=O.CC(=O)NCC(O)=O.NC(=N)C1=CC=C(NN=NC2=CC=C(C=C2)C(N)=N)C=C1",-0.592,6,5,9]
["S4116","Isovaleramide","d8","L9900-03","in 10mM DMSO","Dehydrogenase","Metabolism","Isovaleramide(3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.",101.15,"541-46-8",{"v":20,"d":"20.00"},197.73,"<1","N/A","http://selleckchem.com/products/isovaleramide.html","C5H11NO","free base","3-Methylbutanamide","CC(C)CC(N)=O",0.542,1,1,2]
["S4155","Chlorzoxazone","e8","L9900-03","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.",169.57,"95-25-0",{"v":34,"d":"34.00"},200.51,"<1","N/A","http://selleckchem.com/products/chlorzoxazone.html","C7H4ClNO2","free base","Chlorzoxazon,Paraflex","ClC1=CC2=C(OC(=O)N2)C=C1",2.004,2,1,0]
["S4164","Doxofylline","f8","L9900-03","in 10mM DMSO","PDE","Metabolism","Doxofylline (Doxophylline) is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.",266.25,"69975-86-6",{"v":53,"d":"53.00"},199.06,{"v":24,"d":"24.00"},90.14,"http://selleckchem.com/products/doxofylline.html","C11H14N4O4","free base","Doxophylline","CN1C(=O)N(C)C2=C([N](CC3OCCO3)C=N2)C1=O",-0.344,5,0,2]
["S4166","Chlorpropamide","g8","L9900-03","in 10mM DMSO","ATPase","Transmembrane Transporters","Chlorpropamide inhibits Na(+),K(+)-ATPase and stimulates a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane. Chlorpropamide is a sulfonylurea class drug for type 2 diabetes mellitus.",276.74,"94-20-2",{"v":55,"d":"55.00"},198.74,"<1","N/A","http://selleckchem.com/products/chlorpropamide.html","C10H13ClN2O3S","free base","N/A","CCCNC(=O)N[S](=O)(=O)C1=CC=C(Cl)C=C1",2.058,3,2,4]
["S4169","Teriflunomide","h8","L9900-03","in 10mM DMSO","Dehydrogenase,Immunology & Inflammation related","Metabolism","Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.",270.21,"163451-81-8",{"v":32,"d":"32.00"},118.43,"<1","N/A","http://selleckchem.com/products/teriflunomide.html","C12H9F3N2O2","free base","A77 1726, HMR-1726","C/C(O)=C(C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F",2.091,1,2,3]
["S4188","Sasapyrine","a9","L9900-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.",258.23,"552-94-3",{"v":52,"d":"52.00"},201.37,"<1","N/A","http://selleckchem.com/products/sasapyrine.html","C14H10O5","free base","NSC-49171,Salsalate","OC(=O)C1=CC=CC=C1OC(=O)C2=CC=CC=C2O",2.649,3,1,4]
["S4206","Cysteamine HCl","b9","L9900-03","in 10mM DMSO","Antioxidant","Metabolism","Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.",113.61,"156-57-0",{"v":23,"d":"23.00"},202.45,{"v":23,"d":"23.00"},202.45,"http://selleckchem.com/products/cysteamine-hcl.html","C2H7NS.HCl","Hydrochloride","Mercaptamine","Cl.NCCS",0.166,0,1,1]
["S4212","Tenatoprazole","c9","L9900-03","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Tenatoprazole (TU-199,STU-Na) is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. Tenatoprazole labels only the gastric H(+),K(+)-ATPase alpha-subunit, approximately 2.6 nM/mg of tenatoprazole is bound to the H(+),K(+)-ATPase.",{"v":346.4,"d":"346.40"},"113712-98-4",{"v":46,"d":"46.00"},132.79,"<1","N/A","http://selleckchem.com/products/tenatoprazole.html","C16H18N4O3S","free base","TU-199,STU-Na","COC1=CC=C2[NH]C(=NC2=N1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.488,6,1,5]
["S4246","Tranylcypromine (2-PCPA) HCl","d9","L9900-03","in 10mM DMSO","MAO","Metabolism","Tranylcypromine HCl (2-PCPA, SKF-385, Parnate) is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.",169.65,"1986-47-6",{"v":33,"d":"33.00"},194.52,{"v":33,"d":"33.00"},194.52,"http://selleckchem.com/products/tranylcypromine-2-pcpa-hcl.html","C9H12ClN","Hydrochloride","SKF-385 HCl, Parnate,2-PCPA","Cl.NC1CC1C2=CC=CC=C2",2.309,0,1,1]
["S4255","Quinacrine 2HCl","e9","L9900-03","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective  phospholipase A2 inhibitor.",472.88,"69-05-6",{"v":14,"d":"14.00"},29.61,{"v":53,"d":"53.00"},112.08,"http://selleckchem.com/products/quinacrine-2hcl.html","C23H30ClN3O.2HCl","Dihydrochloride","Quinacrine dihydrochloride","Cl.Cl.CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC3=CC(=CC=C13)Cl",{"v":6.43,"d":"6.430"},2,1,9]
["S4256","Buspirone HCl","f9","L9900-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Buspirone(Buspirone hydrochloride) is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.",421.96,"33386-08-2",{"v":84,"d":"84.00"},199.07,{"v":84,"d":"84.00"},199.07,"http://selleckchem.com/products/buspirone-hcl.html","C21H31N5O2.HCl","Hydrochloride","Buspirone hydrochloride","Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)C4=NC=CC=N4",2.403,4,0,6]
["S4263","Efaproxiral Sodium","g9","L9900-03","in 10mM DMSO","ROS","Immunology & Inflammation","Efaproxiral Sodium(RSR13 Sodium) is a synthetic allosteric modifier of hemoglobin, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy. Efaproxiral Sodium is used for brain metastases originating from breast cancer.",363.38,"170787-99-2",{"v":73,"d":"73.00"},200.89,{"v":73,"d":"73.00"},200.89,"http://selleckchem.com/products/efaproxiral-sodium.html","C20H23NO4.Na","Sodium salt","RSR13 Sodium","[Na+].CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(OC(C)(C)C([O-])=O)C=C2)C",2.408,2,1,6]
["S4284","Chloroprocaine HCl","h9","L9900-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Chloroprocaine HCl is a local anesthetic during surgical procedures.",307.22,"3858-89-7",{"v":61,"d":"61.00"},198.55,{"v":61,"d":"61.00"},198.55,"http://selleckchem.com/products/chloroprocaine-hci.html","C13H20Cl2N2O2","Hydrochloride","N/A","Cl.CCN(CC)CCOC(=O)C1=C(Cl)C=C(N)C=C1",2.821,2,1,7]
["S4342","Nialamide","a10","L9900-03","in 10mM DMSO","MAO","Others","Nialamide is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class used as an antidepressant and anxiolytic.",298.34,"51-12-7",{"v":59,"d":"59.00"},197.76,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/nialamide.html","C16H18N4O2","Free Base","N/A","O=C(CCNNC(=O)C1=CC=NC=C1)NCC2=CC=CC=C2",0.287,3,3,7]
["S4353","Terfenadine","b10","L9900-03","in 10mM DMSO","Calcium Channel,Caspase,Histamine Receptor,NCX,Potassium Channel","Transmembrane Transporters","Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.  Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.",471.67,"50679-08-8",{"v":94,"d":"94.00"},199.29,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/terfenadine.html","C32H41NO2","Free Base","N/A","CC(C)(C)C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",6.498,0,1,9]
["S4511","6-Benzylaminopurine","c10","L9900-03","in 10mM DMSO","ROS","Immunology & Inflammation","6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.",225.25,"1214-39-7",{"v":45,"d":"45.00"},199.78,"<1","N/A","http://selleckchem.com/products/6-benzylaminopurine.html","C12H11N5","free base","N/A","C(NC1=NC=NC2=C1[NH]C=N2)C3=CC=CC=C3",1.693,3,2,3]
["S4538","Pantoprazole sodium","d10","L9900-03","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",405.35,"138786-67-1",{"v":81,"d":"81.00"},199.83,{"v":81,"d":"81.00"},199.83,"http://selleckchem.com/products/pantoprazole-sodium.html","C16H14F2N3NaO4S","Free Base","SKF96022 sodium, BY-1023 sodium","[Na+].COC1=CC=NC(=C1OC)C[S](=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F",2.883,6,0,7]
["S4539","Salicylic acid","e10","L9900-03","in 10mM DMSO","COX","Neuronal Signaling","Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.",138.12,"69-72-7",{"v":27,"d":"27.00"},195.48,"<1","N/A","http://selleckchem.com/products/salicylic-acid.html","C7H6O3","free base","2-Hydroxybenzoic acid","OC(=O)C1=C(O)C=CC=C1",1.217,1,1,1]
["S4601","Clioquinol","f10","L9900-03","in 10mM DMSO","Fungal","Microbiology","Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.",{"v":305.5,"d":"305.50"},"130-26-7",{"v":61,"d":"61.00"},199.67,"<1","N/A","http://selleckchem.com/products/5-chloro-8-hydroxy-7-iodoquinoline.html","C9H5ClINO","free base","Iodochlorhydroxyquin, Chinoform","OC1=C(I)C=C(Cl)C2=CC=CN=C12",3.016,1,1,0]
["S4603","Gallic acid","g10","L9900-03","in 10mM DMSO","ROS","Immunology & Inflammation","Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.",170.12,"149-91-7",{"v":34,"d":"34.00"},199.86,{"v":7,"d":"7.00"},41.15,"http://selleckchem.com/products/gallic-acid.html","C7H6O5","free base","3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid","OC(=O)C1=CC(=C(O)C(=C1)O)O",0.733,1,3,1]
["S4612","Dapson","h10","L9900-03","in 10mM DMSO","Antibiotics","Microbiology","Dapson (Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS), also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.",{"v":248.3,"d":"248.30"},"80-08-0",{"v":49,"d":"49.00"},197.34,"<1","N/A","http://selleckchem.com/products/dapson.html","C12H12N2O2S","free base","Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS","NC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(N)C=C2",1.439,2,2,2]
["S4630","Diazoxide","a11","L9900-03","in 10mM DMSO","ADC Cytotoxin,Potassium Channel","Transmembrane Transporters","Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.",230.67,"364-98-7",{"v":46,"d":"46.00"},199.42,"<1","N/A","http://selleckchem.com/products/diazoxide.html","C8H7ClN2O2S","free base","Sch-6783, SRG-95213, Proglycem","CC1=NC2=CC=C(Cl)C=C2[S](=O)(=O)N1",1.196,3,1,0]
["S4662","Atazanavir","b11","L9900-03","in 10mM DMSO","HIV Protease,P450 (e.g. CYP17),P-gp","Proteases","Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.",704.86,"198904-31-3",{"v":71,"d":"71.00"},100.73,"<1","N/A","http://selleckchem.com/products/atazanavir-reyataz.html","C38H52N6O7","free base","Latazanavir, Zrivada, Reyataz, BMS-232632","COC(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(O)CN(CC2=CC=C(C=C2)C3=NC=CC=C3)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C",{"v":4.69,"d":"4.690"},7,5,18]
["S4686","Vitamin E","c11","L9900-03","in 10mM DMSO","COX,VEGFR","Neuronal Signaling","Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.",430.71,"59-02-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e.html","C29H50O2","free base","Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O",{"v":10.44,"d":"10.440"},1,1,12]
["S4698","Vitamin K1","d11","L9900-03","in 10mM DMSO","Vitamin","Metabolism","Vitamin K1 (Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione), made by plants, is a major type of dietary vitamin K, which is well-known for its role in blood clotting. Vitamin K1 is directly involved in photosynthesis.",{"v":450.7,"d":"450.70"},"84-80-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/vitamin-k1.html","C31H46O2","2-methyl-1,4-naphthoquinones","Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione","CC(C)CCCC(C)CCCC(C)CCC/C(C)=C/CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O",{"v":10.25,"d":"10.250"},2,0,14]
["S4701","2-Deoxy-D-glucose (2-DG)","e11","L9900-03","in 10mM DMSO","Apoptosis related,Carbohydrate Metabolism,HSV","Metabolism","2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.",164.16,"154-17-6",{"v":32,"d":"32.00"},194.93,{"v":32,"d":"32.00"},194.93,"http://selleckchem.com/products/2-deoxy-d-glucose.html","C6H12O5","free base","2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose","OCC1OC(O)CC(O)C1O",-1.748,1,3,1]
["S4706","Eugenol","f11","L9900-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eugenol (4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol) is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.",{"v":164.2,"d":"164.20"},"97-53-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/eugenol.html","C10H12O2","Free Base","4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol","COC1=C(O)C=CC(=C1)CC=C",2.579,1,1,3]
["S4707","Oleic Acid","g11","L9900-03","in 10mM DMSO","ATPase","Transmembrane Transporters","Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid) is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent.  Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.",282.46,"112-80-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/oleic-acid.html","C18H34O2","Free Base","Oleate, 9-Octadecenoic Acid, Elaidoic acid","CCCCCCCC\\C=C/CCCCCCCC(O)=O",{"v":6.86,"d":"6.860"},1,0,15]
["S4717","Isatin","h11","L9900-03","in 10mM DMSO","MAO","Metabolism","Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor with an IC50 of 15 μM and more active against MAO-B than MAO-A.",147.13,"91-56-5",{"v":29,"d":"29.00"},{"v":197.1,"d":"197.10"},"<1","N/A","http://selleckchem.com/products/isatin.html","C8H5NO2","free base","2,3-Indolinedione","O=C1NC2=C(C=CC=C2)C1=O",{"v":0.67,"d":"0.670"},2,1,0]
["S4722","(+)-Catechin","a2","L9900-04","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.,",290.27,"154-23-4",{"v":58,"d":"58.00"},199.81,{"v":58,"d":"58.00"},199.81,"http://selleckchem.com/products/catechin.html","C15H14O6","free base","Cianidanol, Catechinic acid, Catechuic acid, Catechin","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4723","(-)Epicatechin","b2","L9900-04","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(−)Epicatechin (L-Epicatechin, (-)-Epicatechol) is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.",290.27,"490-46-0",{"v":58,"d":"58.00"},199.81,"<1","N/A","http://selleckchem.com/products/-epicatechin.html","C15H14O6","free base","L-Epicatechin, (-)-Epicatechol","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4746","(20S)-Protopanaxadiol","c2","L9900-04","in 10mM DMSO","P-gp","Transmembrane Transporters","20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.",460.73,"30636-90-9",{"v":92,"d":"92.00"},199.68,"<1","N/A","http://selleckchem.com/products/20s-protopanaxadiol.html","C30H52O3","free base","20-Epiprotopanaxadiol","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4CCC23C",5.789,0,2,4]
["S4753","Ganoderic acid A","d2","L9900-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.",516.67,"81907-62-2",{"v":100,"d":"100.00"},193.55,"<1","N/A","http://selleckchem.com/products/ganoderic-acid-a.html","C30H44O7","free base","N/A","CC(CC(=O)CC(C)C(O)=O)C1CC(O)C2(C)C3=C(C(=O)CC12C)C4(C)CCC(=O)C(C)(C)C4CC3O",2.775,4,2,6]
["S4761","Thymoquinone","e2","L9900-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa with anti-inflammatory and anti-oxidant effects.",{"v":164.2,"d":"164.20"},"490-91-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/thymoquinone.html","C10H12O2","free base","N/A","CC(C)C1=CC(=O)C(=CC1=O)C",2.288,2,0,1]
["S4771","β-thujaplicin","f2","L9900-04","in 10mM DMSO","DNA Methyltransferase","Epigenetics","β-Thujaplicin (β-TH, Hinokitiol, 4-Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods.  Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.",{"v":164.2,"d":"164.20"},"499-44-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/beta-thujaplicin.html","C10H12O2","free base","Hinokitiol, 4-Isopropyltropolone","CC(C)C1=CC=CC(=O)C(=C1)O",1.896,1,1,1]
["S4779","Menadiol Diacetate","g2","L9900-04","in 10mM DMSO","Vitamin","Microbiology","Menadiol Diacetate (Vitamin K4, Acetomenaphthone, Kapilin) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It induces caspase-3-related apoptosis pathway via mitochondrial dysfunction and DNA fragmentation.",258.27,"573-20-6",{"v":51,"d":"51.00"},197.47,"N/A","N/A","http://selleckchem.com/products/menadiol-diacetate.html","C15H14O4","free base","Vitamin K4, Acetomenaphthone, Kapilin","CC(=O)OC1=C2C=CC=CC2=C(OC(C)=O)C(=C1)C",2.759,4,0,4]
["S4805","Carboxine","h2","L9900-04","in 10mM DMSO","Dehydrogenase","Metabolism","Carboxin (Carbathiin, Vitavax, Kisvax) is a systemic agricultural fungicide and seed protectant. Carboxin inhibits succinate dehydrogenaseactivity .",{"v":235.3,"d":"235.30"},"5234-68-4",{"v":47,"d":"47.00"},199.75,"N/A","N/A","http://selleckchem.com/products/carboxine.html","C12H13NO2S","free base","Carbathiin, Vitavax, Kisvax, Carboxin","CC1=C(SCCO1)C(=O)NC2=CC=CC=C2",{"v":0,"d":"0.000"},0,0,0]
["S4809","3-Indolepropionic acid","a3","L9900-04","in 10mM DMSO","Others","Others","3-Indolepropionic acid (IPA, indole-3-propionic acid), a gut microbial metabolite, is a potent neuroprotective antioxidant and plant auxin.",189.21,"830-96-6",{"v":37,"d":"37.00"},195.55,"N/A","N/A","http://selleckchem.com/products/3-indolepropionic-acid.html","C11H11NO2","free base","indole-3-propionic acid, Indolepropionic acid","OC(=O)CCC1=C[NH]C2=C1C=CC=C2",{"v":0,"d":"0.000"},0,0,0]
["S4845","Rabeprazole","b3","L9900-04","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Rabeprazole(LY307640) is an oral inhibitor of proton pump and blocks the production of acid by the stomach.",359.44,"117976-89-3",{"v":71,"d":"71.00"},197.53,{"v":71,"d":"71.00"},197.53,"http://selleckchem.com/products/rabeprazole.html","C18H21N3O3S","free base","LY307640","COCCCOC1=C(C)C(=NC=C1)C[S](=O)C2=NC3=C([NH]2)C=CC=C3",2.366,5,1,8]
["S4853","Ecabet sodium","c3","L9900-04","in 10mM DMSO","ROS","Apoptosis","Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. Ecabet sodium inhibits the ability of Helicobacter pylori to induce neutrophil production of reactive oxygen species and interleukin-8, Ecabet sodium can also reduce apoptosis.",402.48,"86408-72-2",{"v":80,"d":"80.00"},198.77,{"v":16,"d":"16.00"},39.75,"http://selleckchem.com/products/ecabet-sodium.html","C20H27O5S.Na","sodium salt","TA-2711, TA-2711E","[Na+].CC(C)C1=CC2=C(C=C1[S]([O-])(=O)=O)C3(C)CCCC(C)(C3CC2)C(O)=O",2.477,1,0,3]
["S4856","Iproniazid","d3","L9900-04","in 10mM DMSO","MAO","Metabolism","Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.",179.22,"54-92-2",{"v":35,"d":"35.00"},195.29,{"v":35,"d":"35.00"},195.29,"http://selleckchem.com/products/Iproniazid.html","C9H13N3O","free base","Marsilid, Iprazid","CC(C)NNC(=O)C1=CC=NC=C1",0.121,2,2,3]
["S4862","Squalene","e3","L9900-04","in 10mM DMSO","Fungal","Microbiology","Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.",410.72,"111-02-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/squalene.html","C30H50","free base","Spinacene, Supraene, trans-Squalene","CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C=C(C)\\CC\\C=C(C)\\CCC=C(C)C",11.331,0,0,15]
["S4900","Tenovin-6","f3","L9900-04","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.",454.63,"1011557-82-6",{"v":98,"d":"98.00"},215.56,{"v":98,"d":"98.00"},215.56,"http://selleckchem.com/products/tenovin-6.html","C25H34N4O2S","free base","N/A","Cl.CN(C)CCCCC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",{"v":5.7,"d":"5.700"},2,3,11]
["S4953","Usnic acid","g3","L9900-04","in 10mM DMSO","Akt,ERK","PI3K/Akt/mTOR","Usnic acid (Usniacin) is a furandione found uniquely in lichen that is used widely in cosmetics, deodorants, toothpaste and medicinal creams as well as some herbal products. It exhibits antiviral, antiprotozoal, antiproliferative, anti-inflammatory and analgesic activity. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways.",344.32,"125-46-2",{"v":4,"d":"4.00"},11.62,"N/A","N/A","http://selleckchem.com/products/usnic-acid.html","C18H16O7","free base","Usniacin","CC(=O)C1C(=O)C=C2OC3=C(C(=C(C)C(=C3C(C)=O)O)O)C2(C)C1=O",1.084,5,2,2]
["S4970","Nerol","h3","L9900-04","in 10mM DMSO","Fungal,ROS","Apoptosis","Nerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. Nerol has antifungal activity, Nerol can trigger mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS leading to apoptosis.",154.25,"106-25-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/nerol.html","C10H18O","free base","Cis-Geraniol, Neryl alcohol","CC(C)=CCC\\C(C)=C/CO",2.934,0,1,4]
["S4999","Avermectin B1","a4","L9900-04","in 10mM DMSO","Parasite","Microbiology","Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.",873.08,"71751-41-2",{"v":100,"d":"100.00"},114.54,"N/A","N/A","http://selleckchem.com/products/avermectin.html","C48H72O14","Macrocyclic lactones","abamectin","CCC(C)C1OC2(CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2)C=CC1C",4.692,11,2,8]
["S5037","Phenazine methosulfate","b4","L9900-04","in 10mM DMSO","Others","Others","Phenazine methosulfate (N-Methylphenazonium methosulfate, 5-Methylphenazinium methyl sulfate) is widely used as an intermediate electron carrier for coupling the production of NADH or NADPH to the reduction of tetrazolium salts to coloured formazans.",306.34,"299-11-6",{"v":61,"d":"61.00"},199.13,"N/A","N/A","http://selleckchem.com/products/phenazine-methosulfate.html","C13H11N2.CH3O4S","methosulfate","N-Methylphenazonium methosulfate, 5-Methylphenazinium methyl sulfate","CO[S]([O-])(=O)=O.C[N+]1=C2C=CC=CC2=NC3=CC=CC=C13",0.727,2,0,1]
["S5058","Revaprazan Hydrochloride","c4","L9900-04","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.",{"v":398.9,"d":"398.90"},"178307-42-1",{"v":16,"d":"16.00"},40.11,"N/A","N/A","http://selleckchem.com/products/revaprazan-hydrochloride.html","C22H23FN4.HCl","HCl","YH1885","Cl.CC1N(CCC2=C1C=CC=C2)C3=NC(=NC(=C3C)C)NC4=CC=C(F)C=C4",6.215,2,1,3]
["S5082","Vitamin K2","d4","L9900-04","in 10mM DMSO","Vitamin","Metabolism","Vitamin K2 (Menaquinone) is an important fat-soluble vitamin that plays critical roles in protecting heart and brain, and building strong bones. It also plays an important role in cancer protection.",444.65,"863-61-6",{"v":88,"d":"88.00"},197.91,"N/A","N/A","http://selleckchem.com/products/vitamin-k2.html","C31H40O2","free base","Menaquinone","CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O",{"v":9.5,"d":"9.500"},2,0,11]
["S5146","3-Methylpyrazole","e4","L9900-04","in 10mM DMSO","Dehydrogenase","Metabolism","3-Methylpyrazole (3-MP) is a weak or non-inhibitor of alcohol dehydrogenase.",{"v":82.1,"d":"82.10"},"1453-58-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/3-methylpyrazole.html","C4H6N2","free base","3-MP","CC1=N[NH]C=C1",{"v":0,"d":"0.000"},0,0,0]
["S5154","Tetrahydropiperine","f4","L9900-04","in 10mM DMSO","Others","Others","Tetrahydropiperine (Cosmoperine), derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.",289.37,"23434-88-0",{"v":57,"d":"57.00"},196.98,"N/A","N/A","http://selleckchem.com/products/tetrahydropiperine.html","C17H23NO3","free base","Cosmoperine","O=C(CCCCC1=CC2=C(OCO2)C=C1)N3CCCCC3",3.332,3,0,5]
["S5159","Doxycycline","g4","L9900-04","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial,MMP","Microbiology","Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.",444.43,"564-25-0",{"v":88,"d":"88.00"},198.01,"N/A","N/A","http://selleckchem.com/products/doxycycline.html","C22H24N2O8","free base","Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum","CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C1C=CC=C4O)O)O",{"v":0,"d":"0.000"},0,0,0]
["S5169","2,6-Dihydroxyanthraquinone","h4","L9900-04","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","2,6-Dihydroxyanthraquinone (Anthraflavic acid, Anthraflavin) is a potent and specific inhibitor of cytochrome P-448 activity.",240.21,"84-60-6",{"v":48,"d":"48.00"},199.83,"N/A","N/A","http://selleckchem.com/products/2-6-dihydroxyanthraquinone.html","C14H8O4","free base","Anthraflavic acid, Anthraflavin","OC1=CC2=C(C=C1)C(=O)C3=CC(=CC=C3C2=O)O",{"v":0,"d":"0.000"},0,0,0]
["S5208","Ciprofloxacin hydrochloride hydrate","a5","L9900-04","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Ciprofloxacin Hydrochloride (Ciloxan, Ceprimax, Oftacilox,Bay-09867 hydrochloride hydrate) is the hydrochloride salt form of ciprofloxacin, which is an antibiotic used to treat a number of bacterial infections.",385.82,"86393-32-0",{"v":8,"d":"8.00"},20.74,"N/A","N/A","http://selleckchem.com/products/ciprofloxacin-hydrochloride-hydrate.html","C17H18FN3O3.HCl.H2O","hydrochloride hydrate","Ciloxan, Ceprimax, Oftacilox,Bay-09867 hydrochloride hydrate","O.Cl.OC(=O)C1=CN(C2CC2)C3=C(C=C(F)C(=C3)N4CCNCC4)C1=O",-1.095,2,1,3]
["S5243","Ruxolitinib Phosphate","b5","L9900-04","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",404.36,"1092939-17-7",{"v":80,"d":"80.00"},197.84,{"v":29,"d":"29.00"},71.72,"http://selleckchem.com/products/ruxolitinib-phosphate.html","C17H18N6.H3O4P","phosphate","INCB018424, INC424","O[P](O)(O)=O.N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",2.412,3,1,4]
["S5266","Stiripentol","c5","L9900-04","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.",234.29,"49763-96-4",{"v":46,"d":"46.00"},196.34,{"v":13,"d":"13.00"},55.49,"http://selleckchem.com/products/stiripentol.html","C14H18O3","Dioxolane","BCX2600","CC(C)(C)C(O)/C=C/C1=CC=C2OCOC2=C1",2.955,2,1,3]
["S5269","J147","d5","L9900-04","in 10mM DMSO","MAO","Neuronal Signaling","J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging.",350.33,"1146963-51-0",{"v":70,"d":"70.00"},199.81,"N/A","N/A","http://selleckchem.com/products/j147.html","C18H17F3N2O2","free base","N/A","COC1=CC(=CC=C1)/C=N/N(C(=O)C(F)(F)F)C2=CC=C(C)C=C2C",4.845,3,0,5]
["S5304","2-Acetylphenothiazine (ML171)","e5","L9900-04","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.",241.31,"6631-94-3",{"v":48,"d":"48.00"},198.91,"N/A","N/A","http://selleckchem.com/products/2-acetylphenothiazine-ml171.html","C14H11NOS","free base","2-APT","CC(=O)C1=CC=C2SC3=C(NC2=C1)C=CC=C3",3.408,1,1,1]
["S5312","Urolithin A","f5","L9900-04","in 10mM DMSO","Mitophagy","Autophagy","Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.",{"v":228.2,"d":"228.20"},"1143-70-0",{"v":45,"d":"45.00"},{"v":197.2,"d":"197.20"},"<1","N/A","http://selleckchem.com/products/urolithin-a.html","C13H8O4","free base","3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin","OC1=CC=C2C(=C1)OC(=O)C3=CC(=CC=C23)O",2.466,2,2,0]
["S5314","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","g5","L9900-04","in 10mM DMSO","ROS","Immunology & Inflammation","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent. HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone) has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS), including peroxyl radicals, and scavenging them to form more stable free radicals.",236.35,"148081-72-5",{"v":47,"d":"47.00"},198.86,"N/A","N/A","http://selleckchem.com/products/hthq-1-o-hexyl-2-3-5-trimethylhydroquinone.html","C15H24O2","Hydroquinones","N/A","CCCCCCOC1=CC(=C(O)C(=C1C)C)C",5.271,1,1,6]
["S5316","NU2058","h5","L9900-04","in 10mM DMSO","CDK","Cell Cycle","NU2058 (O(6)-Cyclohexylmethylguanine) is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay. It also potentiates melphalan (DMF 2.3), and monohydroxymelphalan (1.7), but not temozolomide or ionising radiation.",{"v":247.3,"d":"247.30"},"161058-83-9",{"v":49,"d":"49.00"},198.14,"<1","N/A","http://selleckchem.com/products/nu2058.html","C12H17N5O","free base","O(6)-Cyclohexylmethylguanine","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3CCCCC3",2.251,4,2,3]
["S5317","UK 5099","a6","L9900-04","in 10mM DMSO","Mitochondrial pyruvate carrier","Metabolism","UK5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier, inhibiting pyruvate transport across the plasma membrane of trypanosomes with Ki value of 49 μM.",{"v":288.3,"d":"288.30"},"56396-35-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/uk5099.html","C18H12N2O2","Mitochondrial pyruvate carrier","PF-1005023","OC(=O)\\C(=C\\C1=C[N](C2=CC=CC=C2)C3=C1C=CC=C3)C#N",3.842,1,0,3]
["S5357","Safinamide","b6","L9900-04","in 10mM DMSO","MAO","Metabolism","Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible <v>monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.",302.34,"133865-89-1",{"v":60,"d":"60.00"},198.45,{"v":-1,"d":"-1.00"},-3.31,"http://selleckchem.com/products/safinamide.html","C17H19FN2O2","free base","EMD-1195686, PNU-15774E","CC(NCC1=CC=C(OCC2=CC=CC(=C2)F)C=C1)C(N)=O",2.478,2,2,7]
["S5369","Ethoxyquin","c6","L9900-04","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Ethoxyquin (Santoquin, Santoflex, Quinol) is an antioxidant used as a food preservative.  Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).",217.31,"91-53-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/ethoxyquin.html","C14H19NO","free base","Santoquin, Santoflex, Quinol","CCOC1=CC2=C(NC(C)(C)C=C2C)C=C1",3.221,1,1,2]
["S5372","Methyl Aminolevulinate Hydrochloride","d6","L9900-04","in 10mM DMSO","Others","Others","Methyl Aminolevulinate (Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride) is a prodrug that is metabolised to protoporphyrin IX used in photodynamic therapy.",181.62,"79416-27-6",{"v":36,"d":"36.00"},198.22,{"v":-1,"d":"-1.00"},-5.51,"https://www.selleckchem.com/products/methyl-aminolevulinate-hydrochloride.html","C6H12ClNO3","free base","Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride","Cl.COC(=O)CCC(=O)CN",-0.613,3,1,5]
["S5425","Phenylglyoxal hydrate","e6","L9900-04","in 10mM DMSO","Dehydrogenase","Metabolism","Phenylglyoxal (1-Phenylethanedione) is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.",152.15,"1075-06-5",{"v":30,"d":"30.00"},197.17,"N/A","N/A","http://selleckchem.com/products/phenylglyoxal-hydrate.html","C8H8O3","free base","1-Phenylethanedione hydrate","OC(O)C(=O)C1=CC=CC=C1",0.777,1,0,2]
["S5435","Quinacrine Dihydrochloride Dihydrate","f6","L9900-04","in 10mM DMSO","Others","Others","Quinacrine (Mepacrine) is a dye of the acridine family that has been widely used as staining agents for DNA and model compounds for intercalators in numerous biophysical studies. It is also an antimalarial drug.",508.91,"6151-30-0",{"v":10,"d":"10.00"},19.65,"N/A","N/A","http://selleckchem.com/products/quinacrine-dihydrochloride-dihydrate.html","C23H30ClN3O.2HCl.2H2O","dihydrochloride, dihydrate","Mepacrine Dihydrochloride Dihydrate","O.O.Cl.Cl.CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC3=CC(=CC=C13)Cl",6.015,2,1,9]
["S5440","Berberine Sulfate","g6","L9900-04","in 10mM DMSO","Bacterial","Microbiology","Berberine sulfate (Umbellatine), an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.",433.43,"633-66-9",{"v":20,"d":"20.00"},46.14,"N/A","N/A","http://selleckchem.com/products/berberine-sulfate.html","C20H18NO4.HO4S","sulfate","Umbellatine Sulfate","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4.O[S]([O-])(=O)=O",1.111,4,0,2]
["S5452","Sanguinarine chloride","h6","L9900-04","in 10mM DMSO","phosphatase,ROS","Immunology & Inflammation","Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.",367.78,"5578-73-4",{"v":5,"d":"5.00"},{"v":13.6,"d":"13.60"},"<1","N/A","http://selleckchem.com/products/sanguinarine-chloride.html","C20H14NO4.Cl","chloride","N/A","[Cl-].C[N+]1=CC2=C3OCOC3=CC=C2C4=CC=C5C=C6OCOC6=CC5=C14",1.313,4,0,0]
["S5454","Saikosaponin D","a7","L9900-04","in 10mM DMSO","ATPase","Transmembrane Transporters","Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.",780.98,"20874-52-6",{"v":100,"d":"100.00"},128.04,"<1","N/A","http://selleckchem.com/products/saikosaponin-d.html","C42H68O13","free base","N/A","CC1OC(OC2CCC3(C)C(CCC4(C)C3C=CC56OCC7(CCC(C)(C)CC57)C(O)CC46C)C2(C)CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C1O",1.107,5,8,6]
["S5456","Isobavachalcone","b7","L9900-04","in 10mM DMSO","Bacterial","Microbiology","Isobavachalcone (Corylifolinin), a naturally occurring chalcone compound derived from the seeds of Psoralea corylifolia L., has long been used in traditional Chinese medicine as anthelmintic, antibacterial, aphrodisiac, astringent and antiplatelet agent.",324.37,"20784-50-3",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/isobavachalcone.html","C20H20O4","free base","Corylifolinin","CC(C)=CCC1=C(O)C(=CC=C1O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.832,1,3,5]
["S5464","Psoralidin","c7","L9900-04","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Psoralidin, a naturally occurring coumestan isolated from the fractions of organic solvents such as ethylacetate, hexane, or n-butanol of the seed extract of Psoralea corylifolia L., has a variety of biological activities such as anticancer, antioxidant, antibacterial, antidepressant, anti-inflammatory activities, and regulation of insulin signaling. It is an agonist for both estrogen receptor (ER)α and ERβ with binding affinities (IC50s) of 1.03 and 24.6 μM, respectively.",336.34,"18642-23-4",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/psoralidin.html","C20H16O5","free base","N/A","CC(C)=CCC1=CC2=C(OC(=O)C3=C2OC4=C3C=CC(=C4)O)C=C1O",4.917,3,2,2]
["S5502","Ilaprazole sodium","d7","L9900-04","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.",388.42,"172152-50-0",{"v":78,"d":"78.00"},200.81,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/iiaprazole-sodium.html","C19H17N4NaO2S","Sodium Salt","IY-81149 sodium","COC1=C(C)C(=NC=C1)C[S](=O)C2=NC3=C(C=CC(=C3)[N]4C=CC=C4)[N]2[Na]",3.414,4,0,5]
["S5503","O-Acetyl-L-carnitine hydrochloride","e7","L9900-04","in 10mM DMSO","Others","Others","O-Acetyl-L-carnitine (Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine) can be synthesis or is naturally found in healthy humans. It could help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs.",{"v":239.7,"d":"239.70"},"5080-50-2",{"v":48,"d":"48.00"},200.25,{"v":-1,"d":"-1.00"},-4.17,"https://www.selleckchem.com/products/o-acetyl-l-carnitine-hydrochloride.html","C9H18ClNO4","Salt","Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine","[Cl-].CC(=O)OC(CC(O)=O)C[N+](C)(C)C",-4.111,3,0,6]
["S5550","Ethyl gallate","f7","L9900-04","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Ethyl gallat (Phyllemblin, gallic acid ethyl ester), which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity. Ethyl gallat activates the death receptor-dependent pathway of apoptosis by enhancing the expression of caspases-8, -9, and -3 and the Bcl-2 interacting domain (Bid).",198.17,"831-61-8",{"v":39,"d":"39.00"},{"v":196.8,"d":"196.80"},"N/A","N/A","https://www.selleckchem.com/products/ethyl-gallate.html","C9H10O5","Ester","Phyllemblin, gallic acid ethyl ester","CCOC(=O)C1=CC(=C(O)C(=C1)O)O",1.308,2,3,3]
["S5600","Flavokawain A","g7","L9900-04","in 10mM DMSO","Bcl-2,IAP,Survivin","Apoptosis","Flavokawain A, extracted from kava, is an apoptotic inducers and anticarcinogenic agent. Flavokawain A can down-regulation of antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then induce cell death in tumor cells.",314.33,"3420-72-2",{"v":32,"d":"32.00"},{"v":101.8,"d":"101.80"},{"v":-1,"d":"-1.00"},-3.18,"https://www.selleckchem.com/products/flavokawain-a.html","C18H18O5","free base","2'-HYDROXY-4, 4', 6'-TRIMETHOXYCHALCONE","COC1=CC=C(/C=C/C(=O)C2=C(OC)C=C(OC)C=C2O)C=C1",{"v":3.41,"d":"3.410"},4,1,6]
["S5623","Bedaquiline","h7","L9900-04","in 10mM DMSO","ATPase","Transmembrane Transporters","Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).",{"v":555.5,"d":"555.50"},"843663-66-1",{"v":12,"d":"12.00"},{"v":21.6,"d":"21.60"},"<1","N/A","https://www.selleckchem.com/products/bedaquiline.html","C32H31BrN2O2","free base","TMC-207, R207910","COC1=NC2=CC=C(Br)C=C2C=C1C(C3=CC=CC=C3)C(O)(CCN(C)C)C4=CC=CC5=CC=CC=C45",6.933,2,0,8]
["S5663","Minaprine dihydrochloride","a8","L9900-04","in 10mM DMSO","MAO","Metabolism","Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.",{"v":371.3,"d":"371.30"},"25905-77-5",{"v":74,"d":"74.00"},{"v":199.3,"d":"199.30"},{"v":74,"d":"74.00"},{"v":199.3,"d":"199.30"},"https://www.selleckchem.com/products/minaprine-dihydrochloride.html","C17H24Cl2N4O","free base","N/A","Cl.Cl.CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3",3.583,3,1,5]
["S5703","Carvedilol Phosphate","b8","L9900-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.",513.48,"610309-89-2",{"v":100,"d":"100.00"},198.23,{"v":-1,"d":"-1.00"},-1.98,"https://www.selleckchem.com/products/carvedilol-phosphate.html","C24H29N2O8P.1/2H2O","Phosphate","N/A","COC1=C(OCCNCC(O)COC2=CC=CC3=C2C4=C([NH]3)C=CC=C4)C=CC=C1.O[P](O)(O)=O",{"v":4.28,"d":"4.280"},3,3,10]
["S5709","Norgestrel","c8","L9900-04","in 10mM DMSO","ROS","Immunology & Inflammation","Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.",312.45,"6533-00-2",{"v":62,"d":"62.00"},198.43,"<1","N/A","http://selleckchem.com/products/norgestrel.html","C21H28O2","free base","WY-3707, SH-70850, SH-850, FH 122-A","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S5742","Deferoxamine mesylate (Ba 33112)","d8","L9900-04","in 10mM DMSO","Autophagy,Beta Amyloid,Ferroptosis,HIF","Autophagy","Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468) is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.",656.79,"138-14-7",{"v":100,"d":"100.00"},152.26,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/deferoxamine-mesylate.html","C26H52N6O11S","mesylate","Desferrioxamine B, DFOM, NSC 644468","CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.C[S](O)(=O)=O",-1.304,5,3,23]
["S5771","Sulforaphane","e8","L9900-04","in 10mM DMSO","HDAC,Heme Oxygenase,NF-κB,Nrf2,ROS","Immunology & Inflammation","Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.,",177.29,"4478-93-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/sulforaphane.html","C6H11NOS2","Free Base","N/A","C[S](=O)CCCCN=C=S",1.157,2,0,5]
["S5774","CY-09","f8","L9900-04","in 10mM DMSO","NLRP3","Immunology & Inflammation","CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself。 It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.",423.43,"1073612-91-5",{"v":85,"d":"85.00"},200.74,"<1","N/A","http://www.selleckchem.com/products/cy-09.html","C19H12F3NO3S2","Free Base","N/A","OC(=O)C1=CC=C(C=C1)/C=C2/SC(=S)N(CC3=CC(=CC=C3)C(F)(F)F)C2=O",5.202,2,0,5]
["S5779","Trimetazidine","g8","L9900-04","in 10mM DMSO","Others","Metabolism","Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation.",266.34,"5011-34-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/trimetazidine.html","C14H22N2O3","Free Base","N/A","COC1=CC=C(CN2CCNCC2)C(=C1OC)OC",1.275,3,1,5]
["S5791","Cyclic Pifithrin-α hydrobromide","h8","L9900-04","in 10mM DMSO","p53","Apoptosis","Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.",349.29,"511296-88-1",{"v":27,"d":"27.00"},{"v":77.3,"d":"77.30"},{"v":1,"d":"1.00"},2.86,"http://www.selleckchem.com/products/cyclic-pifithrin-hydrobromide.html","C16H17BrN2S","hydrobromide","N/A","Br.CC1=CC=C(C=C1)C2=C[N]3C(=N2)SC4=C3CCCC4",4.616,1,0,1]
["S5795","Rasagiline","a9","L9900-04","in 10mM DMSO","MAO","Metabolism","Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.",171.24,"136236-51-6",{"v":34,"d":"34.00"},198.55,{"v":4,"d":"4.00"},23.36,"http://www.selleckchem.com/products/rasagiline.html","C12H13N","Free Base","TVP-1012","C#CCNC1CCC2=C1C=CC=C2",3.119,0,1,2]
["S5800","Alda 1","b9","L9900-04","in 10mM DMSO","Dehydrogenase","Metabolism","Alda 1 is an ALDH2 agonist that activates catalysis for both wild-type ALDH2 (ALDH2*1) and ALDH2*2.",324.16,"349438-38-6",{"v":65,"d":"65.00"},200.52,"<1","N/A","http://www.selleckchem.com/products/alda-1.html","C15H11Cl2NO3","Free Base","N/A","ClC1=C(C(=O)NCC2=CC=C3OCOC3=C2)C(=CC=C1)Cl",3.718,3,1,3]
["S5804","N-Acetylcysteine amide","c9","L9900-04","in 10mM DMSO","HIF,Immunology & Inflammation related,NF-κB,ROS","Immunology & Inflammation","N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.",162.21,"38520-57-9",{"v":32,"d":"32.00"},197.28,{"v":32,"d":"32.00"},197.28,"http://www.selleckchem.com/products/n-acetylcysteine-amide.html","C5H10N2O2S","Free Base","N/A","CC(=O)NC(CS)C(N)=O",-1.205,2,2,3]
["S5811","Kevetrin hydrochloride","d9","L9900-04","in 10mM DMSO","p53","Apoptosis","Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.",179.67,"66592-89-0",{"v":36,"d":"36.00"},200.37,{"v":36,"d":"36.00"},200.37,"http://www.selleckchem.com/products/kevetrin-hydrochloride.html","C5H10ClN3S","hydrochloride","Thioureidobutyronitrile HCl","Cl.NC(=N)SCCCC#N",1.105,0,1,4]
["S5885","Rabeprazole Related Compound E","e9","L9900-04","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Rabeprazole Related Compound E (Rabeprazole thioether) is an active metabolite of rabeprazole, which is a proton pump inhibitor.",343.44,"117977-21-6",{"v":69,"d":"69.00"},200.91,"<1","N/A","http://www.selleck.cn/products/rabeprazole-related-compound-e.html","C18H21N3O2S","Free Base","Rabeprazole thioether","COCCCOC1=C(C)C(=NC=C1)CSC2=NC3=C([NH]2)C=CC=C3",3.478,4,1,8]
["S5920","CA-5f","f9","L9900-04","in 10mM DMSO","Autophagy","Autophagy","CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.",388.46,"1370032-19-1",{"v":78,"d":"78.00"},200.79,{"v":1,"d":"1.00"},2.57,"http://www.selleckchem.com/products/ca-5f.html","C24H24N2O3","Free Base","N/A","COC1=CC=C(\\C=C2/CN(C)C\\C(=C/C3=C[NH]C4=C3C=CC=C4)C2=O)C=C1OC",4.168,3,1,4]
["S5933","K 858","g9","L9900-04","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","K858 is a novel and potent inhibitor of Eg5 with an IC50 of 1.3 μM for inhibiting the ATPase activity of Eg5, showing at least 150-fold more selective for Eg5 than other members of the kinesin superfamily.",277.34,"72926-24-0",{"v":55,"d":"55.00"},198.31,{"v":1,"d":"1.00"},3.61,"http://www.selleckchem.com/products/k858.html","C13H15N3O2S","Free Base","N/A","CC(=O)NC1=NN(C(C)=O)C(C)(S1)C2=CC=CC=C2",1.535,3,1,2]
["S6002","Disufenton sodium","h9","L9900-04","in 10mM DMSO","Others","Others","Disufenton Sodium (NXY-059, Cerovive) is a novel nitrone, shows efficacious neuroprotective effects. Phase 3.",381.33,"168021-79-2",{"v":76,"d":"76.00"},{"v":199.3,"d":"199.30"},{"v":76,"d":"76.00"},{"v":199.3,"d":"199.30"},"http://selleckchem.com/products/NXY-059.html","C11H13NNa2O7S2","Disodium salt","NXY-059, Cerovive","[Na+].[Na+].CC(C)(C)/[N+]([O-])=C/C1=CC=C(C=C1[S]([O-])(=O)=O)[S]([O-])(=O)=O",-3.972,0,0,4]
["S6008","p-Hydroxybenzaldehyde","a10","L9900-04","in 10mM DMSO","GABA Receptor","Neuronal Signaling","p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. p-Hydroxybenzaldehyde at 101.7 μM can significantly reduce the GABA-induced chloride current of GABAA receptors(α1β2γ2S subtype) expressed.",122.12,"123-08-0",{"v":24,"d":"24.00"},196.53,"N/A","N/A","http://www.selleck.cn/products/p-hydroxybenzaldehyde.html","C7H6O2","free base","4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol","OC1=CC=C(C=O)C=C1",1.347,1,1,1]
["S6042","Trimethylamine N-oxide dihydrate","b10","L9900-04","in 10mM DMSO","Others","Others","Trimethylamine N-oxide dihydrate, a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.",111.14,"62637-93-8",{"v":22,"d":"22.00"},197.95,"N/A","N/A","http://www.selleck.cn/products/trimethylamine-n-oxide-dihydrate.html","C3H13NO3","dihydrate","N/A","O.O.C[N+](C)(C)[O-]",-0.902,0,0,0]
["S6163","Traumatic acid","c10","L9900-04","in 10mM DMSO","Others","Others","Traumatic acid (Trans-2-dodecenedioic acid) is a plant hormone that was first isolated from damaged green beans. It is a potent wound healing agent and an intermediate in prostaglandin synthesis.",228.28,"6402-36-4",45.66,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/traumatic-acid.html","C12H20O4","free base","Trans-2-dodecenedioic acid","OC(=O)CCCCCCCC\\C=C\\C(O)=O",3.267,2,0,10]
["S6281","Sodium Thiocyanate","d10","L9900-04","in 10mM DMSO","Interleukins,ROS","Immunology & Inflammation","Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate), one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Sodium thiocyanate (NaSCN) reduces IL-6, whereas increases IL-10 levels. Sodium thiocyanate also reduces ROS.",81.07,"540-72-7",16.21,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/sodium-thiocyanate.html","CNNaS","free base","Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate","[Na]SC#N",0.625,0,0,0]
["S6286","Tricarballylic acid","e10","L9900-04","in 10mM DMSO","Others","Metabolism","Tricarballylic acid (β-Carboxyglutaric acid, Propane-1,2,3-tricarboxylic acid) is an inhibitor of aconitase and therefore interferes with the Krebs cycle.",176.12,"99-14-9",35.22,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/tricarballylic-acid.html","C6H8O6","free base","Carballylic acid; 1,2,3-Propanetricarboxylic acid; β-Carboxyglutaric acid; Propane-1,2,3-tricarboxylic acid","OC(=O)CC(CC(O)=O)C(O)=O",-0.719,3,0,5]
["S6400","Glucosamine","f10","L9900-04","in 10mM DMSO","HIF","Angiogenesis","Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.",179.17,"3416-24-8",{"v":23,"d":"23.00"},128.37,{"v":36,"d":"36.00"},200.93,"http://www.selleck.cn/products/glucosamine.html","C6H13NO5","Free Base","2-amino-2-deoxy-D-glucose","NC(C=O)C(O)C(O)C(O)CO",-3.081,1,5,5]
["S6417","GK921","g10","L9900-04","in 10mM DMSO","Glutaminase","Proteases","GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition.",344.41,"1025015-40-0",{"v":33,"d":"33.00"},95.82,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/gk921.html","C21H20N4O","Free Base","N/A","C1CCN(C1)CCOC2=NC3=C(N=CC=C3)N=C2C#CC4=CC=CC=C4",3.998,4,0,6]
["S6422","Lazabemide","h10","L9900-04","in 10mM DMSO","MAO","Metabolism","Lazabemide (Ro 19-6327) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM.",{"v":236.1,"d":"236.10"},"103878-83-7",{"v":40,"d":"40.00"},169.42,{"v":40,"d":"40.00"},169.42,"http://www.selleck.cn/products/lazabemide.html","C8H11Cl2N3O","Free Base","Ro 19-6327","Cl.NCCNC(=O)C1=CC=C(Cl)C=N1",0.533,2,2,3]
["S6441","Riboflavin Tetrabutyrate","a11","L9900-04","in 10mM DMSO","Others","Others","Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.",656.72,"752-56-7",{"v":100,"d":"100.00"},152.27,"<1","N/A","http://www.selleck.cn/products/riboflavin-tetrabutyrate.html","C33H44N4O10","Tetrabutyrate","N/A","CCCC(=O)OCC(OC(=O)CCC)C(OC(=O)CCC)C(CN1C2=C(C=C(C)C(=C2)C)N=C3C(=O)NC(=O)N=C13)OC(=O)CCC",5.754,12,1,21]
["S6462","Amezinium (methylsulfate)","b11","L9900-04","in 10mM DMSO","MAO","Neuronal Signaling","Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline.",313.33,"30578-37-1",{"v":63,"d":"63.00"},201.07,{"v":32,"d":"32.00"},102.13,"http://www.selleck.cn/products/amezinium.html","C12H15N3O5S","methylsulfate","N/A","COC1=[N+](N=CC(=C1)N)C2=CC=CC=C2.CO[S]([O-])(=O)=O",{"v":-1.09,"d":"-1.090"},3,1,3]
["S6494","CCCP","c11","L9900-04","in 10mM DMSO","IFN,STING","Immunology & Inflammation","CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP), the protonophore, can inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).",204.62,"555-60-2",{"v":41,"d":"41.00"},200.37,"<1","N/A","http://www.selleck.cn/products/cccp.html","C9H5ClN4","free base","Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone","ClC1=CC=CC(=C1)NN=C(C#N)C#N",2.469,1,1,2]
["S6508","Mitapivat","d11","L9900-04","in 10mM DMSO","PKM","Metabolism","Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.",450.55,"1260075-17-9",{"v":90,"d":"90.00"},199.76,"<1","N/A","http://www.selleck.cn/products/mitapivat.html","C24H26N4O3S","free base","AG-348","O=C(N1CCN(CC1)CC2CC2)C3=CC=C(N[S](=O)(=O)C4=C5N=CC=CC5=CC=C4)C=C3",2.695,4,1,6]
["S7009","LCL161","e11","L9900-04","in 10mM DMSO","IAP,Mitochondrial Metabolism","Apoptosis","LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).",500.63,"1005342-46-0",{"v":100,"d":"100.00"},199.75,"<1","N/A","http://selleckchem.com/products/lcl161.html","C26H33FN4O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(F)C=C4",3.785,4,2,8]
["S7014","Merestinib (LY2801653)","f11","L9900-04","in 10mM DMSO","Axl,c-Met,DDR,FLT3,Mertk,ROS1","Protein Tyrosine Kinase","Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.",552.53,"1206799-15-6",{"v":100,"d":"100.00"},180.99,"<1","N/A","http://selleckchem.com/products/ly2801653-merestinib.html","C30H22F2N6O3","free base","N/A","C[N]1N=CC2=CC(=C(C=C12)C3=C[NH]N=C3)OC4=C(F)C=C(NC(=O)C5=CC=C(C)N(C5=O)C6=CC=C(F)C=C6)C=C4",{"v":4.5,"d":"4.500"},5,2,6]
["S7030","RG-7112","g11","L9900-04","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.",726.28,"939981-39-2",{"v":100,"d":"100.00"},137.69,"<1","N/A","http://selleckchem.com/products/rg-7112.html","C38H48Cl2N4O4S","free base","RO5045337","CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C)(C3=CC=C(Cl)C=C3)C(C)(N2C(=O)N4CCN(CCC[S](C)(=O)=O)CC4)C5=CC=C(Cl)C=C5",7.622,5,0,10]
["S7046","Brefeldin A","h11","L9900-04","in 10mM DMSO","Antibiotics,Apoptosis related,ATPase,Autophagy,CRISPR/Cas9,Mitophagy","Transmembrane Transporters","Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.",280.36,"20350-15-6",{"v":4,"d":"4.00"},14.27,"<1","N/A","http://selleckchem.com/products/brefeldin-a.html","C16H24O4","free base","BFA, Cyanein, Decumbin","CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1",2.152,2,2,0]
["S7079","SGC 0946","a2","L9900-05","in 10mM DMSO","DOT1,Histone Methyltransferase","Epigenetics","SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1.",618.57,"1561178-17-3",{"v":100,"d":"100.00"},161.66,"<1","N/A","http://selleckchem.com/products/sgc-0946.html","C28H40BrN7O4","free base","N/A","CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2OC(C(O)C2O)[N]3C=C(Br)C4=C3N=CN=C4N",3.278,4,5,10]
["S7090","GSK923295","b2","L9900-05","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.",592.13,"1088965-37-0",{"v":100,"d":"100.00"},168.88,"<1","N/A","http://selleckchem.com/products/gsk923295.html","C32H38ClN5O4","free base","N/A","CC(C)OC1=CC=C(C=C1Cl)C(=O)NC(CNC(=O)CN(C)C)CC2=CC=C(C=C2)C3=C[N]4C=CC=C(C(C)O)C4=N3",4.004,4,3,12]
["S7099","(-)-Blebbistatin","c2","L9900-05","in 10mM DMSO","ATPase","Transmembrane Transporters","(-)-Blebbistatin ((S)-(-)-Blebbistatin) is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.",292.33,"856925-71-8",{"v":58,"d":"58.00"},198.41,"<1","N/A","http://selleckchem.com/products/blebbistatin.html","C18H16N2O2","free base","(S)-(-)-Blebbistatin","CC1=CC=C2N=C3N(CCC3(O)C(=O)C2=C1)C4=CC=CC=C4",2.426,2,0,1]
["S7126","Marinopyrrole A (Maritoclax)","d2","L9900-05","in 10mM DMSO","Bcl-2","Apoptosis","Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 μM.",510.15,"1227962-62-0",{"v":100,"d":"100.00"},196.02,"<1","N/A","http://selleckchem.com/products/marinopyrrole-a-maritoclax.html","C22H12Cl4N2O4","free base","N/A","OC1=CC=CC=C1C(=O)C2=C([N]3C(=C(Cl)C=C3C(=O)C4=CC=CC=C4O)Cl)C(=C(Cl)[NH]2)Cl",6.953,2,3,5]
["S7142","NSC697923","e2","L9900-05","in 10mM DMSO","E2 conjugating","Ubiquitin","NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.",267.26,"343351-67-7",{"v":53,"d":"53.00"},198.31,"<1","N/A","http://selleckchem.com/products/nsc697923.html","C11H9NO5S","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(O2)[N+]([O-])=O",2.665,3,0,3]
["S7149","NSC 319726","f2","L9900-05","in 10mM DMSO","p53","Apoptosis","NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.",234.32,"71555-25-4",{"v":19,"d":"19.00"},81.09,"<1","N/A","http://selleckchem.com/products/nsc319726.html","C11H14N4S","free base","N/A","CC(=N\\NC(=S)N1CCC1)/C2=NC=CC=C2",1.906,2,1,4]
["S7162","Mdivi-1","g2","L9900-05","in 10mM DMSO","Apoptosis related,Dynamin,Mitophagy","Cytoskeletal Signaling","Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis.",353.22,"338967-87-6",{"v":70,"d":"70.00"},198.18,"<1","N/A","http://selleckchem.com/products/mdivi-1.html","C15H10Cl2N2O2S","free base","Mitochondrial division inhibitor 1","COC1=C(Cl)C=C(Cl)C(=C1)N2C(=NC3=C(C=CC=C3)C2=O)S",4.943,3,0,2]
["S7171","Setanaxib (GKT137831)","h2","L9900-05","in 10mM DMSO","Ferroptosis,NADPH-oxidase,ROS","Immunology & Inflammation","Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.",394.85,"1218942-37-0",{"v":78,"d":"78.00"},197.54,"<1","N/A","http://selleckchem.com/products/gkt137831.html","C21H19ClN4O2","free base","GKT831","CN(C)C1=CC=CC(=C1)C2=C3C(=O)N(NC3=CC(=O)N2C)C4=CC=CC=C4Cl",2.366,2,1,3]
["S7185","AGI-5198","a3","L9900-05","in 10mM DMSO","Dehydrogenase","Metabolism","AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.",462.56,"1355326-35-0",{"v":24,"d":"24.00"},51.89,"<1","N/A","http://selleckchem.com/products/agi-5198.html","C27H31FN4O2","free base","IDH-C35","CC1=C(C=CC=C1)C(N(C(=O)C[N]2C=CN=C2C)C3=CC(=CC=C3)F)C(=O)NC4CCCCC4",4.354,3,1,7]
["S7205","Idasanutlin (RG-7388)","b3","L9900-05","in 10mM DMSO","MDM2/MDMX","Apoptosis","Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.",616.48,"1229705-06-9",{"v":100,"d":"100.00"},162.21,"<1","N/A","http://selleckchem.com/products/idasanutlin-rg-7388.html","C31H29Cl2F2N3O4","free base","N/A","COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=CC=C(Cl)C=C4F)C=CC(=C1)C(O)=O",{"v":3.85,"d":"3.850"},3,2,8]
["S7207","Bisindolylmaleimide IX (Ro 31-8220 Mesylate)","c3","L9900-05","in 10mM DMSO","PKC","TGF-beta/Smad","Bisindolylmaleimide IX (Ro 31-8220 Mesylate) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.",553.65,"138489-18-6",{"v":100,"d":"100.00"},180.62,"<1","N/A","http://selleckchem.com/products/ro-31-8220-mesylate.html","C25H23N5O2S.CH4O3S","Mesylate","Bisindolylmaleimide IX Mesylate","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](CCCSC(N)=N)C5=CC=CC=C45.C[S](O)(=O)=O",3.452,2,2,7]
["S7230","UNC0642","d3","L9900-05","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels.",{"v":546.7,"d":"546.70"},"1481677-78-4",{"v":100,"d":"100.00"},182.92,"<1","N/A","http://selleckchem.com/products/unc0642.html","C29H44F2N6O2","free base","N/A","COC1=CC2=C(C=C1OCCCN3CCCC3)N=C(N=C2NC4CCN(CC4)C(C)C)N5CCC(F)(F)CC5",4.706,4,1,10]
["S7237","OG-L002","e3","L9900-05","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.",225.29,"1357302-64-7",{"v":45,"d":"45.00"},199.74,"<1","N/A","http://selleckchem.com/products/og-l002.html","C15H15NO","free base","N/A","NC1CC1C2=CC=C(C=C2)C3=CC=CC(=C3)O",{"v":2.47,"d":"2.470"},0,2,2]
["S7241","AGI-6780","f3","L9900-05","in 10mM DMSO","Dehydrogenase","Metabolism","AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.",481.51,"1432660-47-3",{"v":96,"d":"96.00"},199.37,"<1","N/A","http://selleckchem.com/products/agi-6780.html","C21H18F3N3O3S2","free base","N/A","FC(F)(F)C1=CC(=CC=C1)NC(=O)NC2=C(C=CC(=C2)[S](=O)(=O)NC3CC3)C4=CSC=C4",4.046,3,3,7]
["S7262","Vidofludimus","g3","L9900-05","in 10mM DMSO","COVID-19,Dehydrogenase","Metabolism","Vidofludimus (SC12267, 4SC-101) is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Vidofludimus calcium (IMU-838) is investigated as a potential treatment option for COVID-19. Phase 2.",355.36,"717824-30-1",{"v":100,"d":"100.00"},{"v":281.4,"d":"281.40"},"<1","N/A","http://selleckchem.com/products/vidofludimus.html","C20H18FNO4","free base","SC12267, 4SC-101","COC1=CC(=CC=C1)C2=CC(=C(NC(=O)C3=C(CCC3)C(O)=O)C=C2)F",3.878,3,1,5]
["S7266","Golgicide A","h3","L9900-05","in 10mM DMSO","ATPase","Transmembrane Transporters","Golgicide A is a potent and rapidly reversible GBF1 inhibitor.",{"v":284.3,"d":"284.30"},"1139889-93-2",{"v":57,"d":"57.00"},200.49,"<1","N/A","http://selleckchem.com/products/golgicide-a.html","C17H14F2N2","free base","N/A","FC1=CC2=C(NC(C3CC=CC23)C4=CN=CC=C4)C(=C1)F",3.253,1,1,1]
["S7276","SGI-1027","a4","L9900-05","in 10mM DMSO","Apoptosis related,DNA Methyltransferase","Epigenetics","SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively. SGI‑1027 induces apoptosis.",461.52,"1020149-73-8",{"v":92,"d":"92.00"},199.34,"<1","N/A","http://selleckchem.com/products/sgi-1027.html","C27H23N7O","free base","DNA Methyltransferase Inhibitor II","CC1=CC(=NC(=N1)N)NC2=CC=C(NC(=O)C3=CC=C(NC4=CC=NC5=C4C=CC=C5)C=C3)C=C2",4.718,4,4,6]
["S7302","TEPP-46 (ML265)","b4","L9900-05","in 10mM DMSO","PKM","Metabolism","TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.",372.46,"1221186-53-3",{"v":74,"d":"74.00"},198.68,"<1","N/A","http://www.selleckchem.com/products/tepp-46.html","C17H16N4O2S2","Free Base","CID-44246499, NCGC00186528","C[N]1C2=C(SC(=C2)[S](C)=O)C3=C1C(=O)N(CC4=CC=CC(=C4)N)N=C3",2.194,3,1,3]
["S7309","BAY 87-2243","c4","L9900-05","in 10mM DMSO","Ferroptosis,HIF,Mitochondrial Metabolism,ROS","Angiogenesis","BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.",525.53,"1227158-85-1",{"v":33,"d":"33.00"},62.79,"<1","N/A","http://selleckchem.com/products/bay-87-2243.html","C26H26F3N7O2","Free Base","N/A","CC1=CC(=N[N]1CC2=CC=NC(=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(OC(F)(F)F)C=C6",{"v":6.07,"d":"6.070"},6,0,8]
["S7311","Q-VD-Oph","d4","L9900-05","in 10mM DMSO","Caspase,HIV","Apoptosis","Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.",513.49,"1135695-98-5",{"v":100,"d":"100.00"},194.75,"<1","N/A","http://selleckchem.com/products/q-vd-oph.html","C26H25F2N3O6","free base","Quinoline-Val-Asp-Difluorophenoxymethylketone","CC(C)C(NC(=O)C1=NC2=CC=CC=C2C=C1)C(=O)NC(CC(O)=O)C(=O)COC3=C(F)C=CC=C3F",3.397,6,2,11]
["S7316","STF-118804","e4","L9900-05","in 10mM DMSO","NAMPT","Metabolism","STF-118804 is a highly specific NAMPT inhibitor.",461.53,"894187-61-2",{"v":61,"d":"61.00"},132.17,"<1","N/A","http://selleckchem.com/products/stf-118804.html","C25H23N3O4S","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)CC2=C(C)OC(=N2)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4",3.249,6,1,7]
["S7445","APX-3330","f4","L9900-05","in 10mM DMSO","DNA/RNA Synthesis,NF-κB","DNA Damage/DNA Repair","APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.",378.46,"136164-66-4",{"v":75,"d":"75.00"},198.17,"<1","N/A","http://selleckchem.com/products/e3330.html","C21H30O6","free base","E3330","CCCCCCCCCC(=C/C1=C(C)C(=O)C(=C(OC)C1=O)OC)\\C(O)=O",4.663,5,0,12]
["S7448","CORM-3","g4","L9900-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.",294.61,"475473-26-8",{"v":38,"d":"38.00"},128.98,"<1","N/A","http://selleckchem.com/products/corm-3.html","C5H4ClNO5Ru","free base","N/A","Cl[Ru]1(NCC(=O)O1)(C=O)(C=O)C=O",-0.104,5,1,3]
["S7460","BTB06584","h4","L9900-05","in 10mM DMSO","ATPase","Transmembrane Transporters","BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.",417.82,"219793-45-0",{"v":84,"d":"84.00"},201.04,"<1","N/A","http://selleckchem.com/products/btb06584.html","C19H12ClNO6S","free base","N/A","[O-][N+](=O)C1=CC=C(C=C1OC(=O)C2=CC=C(Cl)C=C2)[S](=O)(=O)C3=CC=CC=C3",4.923,4,0,6]
["S7489","YH239-EE","a5","L9900-05","in 10mM DMSO","MDM2/MDMX","Apoptosis","YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.",504.41,"1364488-67-4",{"v":100,"d":"100.00"},198.25,"<1","N/A","http://selleckchem.com/products/yh239-ee.html","C25H27Cl2N3O4","free base","N/A","CCOC(=O)C1=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(=O)NC(C)(C)C)C3=C([NH]1)C=C(Cl)C=C3",4.912,4,2,9]
["S7517","AZD7545","b5","L9900-05","in 10mM DMSO","PDHK","Metabolism","AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.",478.87,"252017-04-2",{"v":95,"d":"95.00"},198.38,"<1","N/A","http://selleckchem.com/products/azd7545.html","C19H18ClF3N2O5S","free base","N/A","CN(C)C(=O)C1=CC=C(C=C1)[S](=O)(=O)C2=CC(=C(NC(=O)C(C)(O)C(F)(F)F)C=C2)Cl",2.913,4,1,6]
["S7531","UMI-77","c5","L9900-05","in 10mM DMSO","Bcl-2","Apoptosis","UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.",468.34,"518303-20-3",{"v":93,"d":"93.00"},198.57,"<1","N/A","http://selleckchem.com/products/umi-77.html","C18H14BrNO5S2","free base","N/A","OC(=O)CSC1=C(O)C2=CC=CC=C2C(=C1)N[S](=O)(=O)C3=CC=C(Br)C=C3",3.755,3,2,6]
["S7536","Lorlatinib (PF-6463922)","d5","L9900-05","in 10mM DMSO","ALK,Apoptosis related,ROS1","Protein Tyrosine Kinase","Lorlatinib (PF-6463922) is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. PF-06463922 induces apoptosis. Phase 1.",406.41,"1454846-35-5",{"v":81,"d":"81.00"},199.31,"<1","N/A","http://selleckchem.com/products/pf-06463922.html","C21H19FN6O2","free base","N/A","CC1OC2=C(N)N=CC(=C2)C3=C(C#N)[N](C)N=C3CN(C)C(=O)C4=C1C=C(F)C=C4",2.343,4,1,0]
["S7551","Piperlongumine","e5","L9900-05","in 10mM DMSO","CRM1,ROS","Immunology & Inflammation","Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.",317.34,"20069-09-4",{"v":16,"d":"16.00"},50.42,"<1","N/A","http://selleckchem.com/products/piperlongumine.html","C17H19NO5","free base","PPLGM, Piplartine","COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O",2.135,5,0,5]
["S7574","GSK-LSD1 2HCl","f5","L9900-05","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).",289.24,"2102933-95-7",{"v":57,"d":"57.00"},197.07,{"v":57,"d":"57.00"},197.07,"http://selleckchem.com/products/gsk-lsd1-2hcl.html","C14H22Cl2N2","dihydrochloride","N/A","Cl.Cl.C1CC(CCN1)NC2CC2C3=CC=CC=C3",1.964,0,2,3]
["S7639","3PO","g5","L9900-05","in 10mM DMSO","PFKFB","Cell Cycle","3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.",210.23,"18550-98-6",{"v":42,"d":"42.00"},199.78,"<1","N/A","http://selleckchem.com/products/3po.html","C13H10N2O","free base","3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one","O=C(/C=C/C1=CC=CN=C1)C2=CC=NC=C2",{"v":1.4,"d":"1.400"},3,0,3]
["S7649","MI-773 (SAR405838)","h5","L9900-05","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.",{"v":562.5,"d":"562.50"},"1303607-60-4",{"v":100,"d":"100.00"},177.78,"<1","N/A","http://selleckchem.com/products/mi-773-sar405838.html","C29H34Cl2FN3O3","free base","N/A","CC(C)(C)CC1NC(C(C2=CC=CC(=C2F)Cl)C13C(=O)NC4=C3C=CC(=C4)Cl)C(=O)NC5CCC(O)CC5",4.856,2,4,5]
["S7655","Telaglenastat (CB-839)","a6","L9900-05","in 10mM DMSO","Autophagy,Glutaminase","Proteases","Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1.",571.57,"1439399-58-2",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/cb-839.html","C26H24F3N7O3S","free base","N/A","FC(F)(F)OC1=CC(=CC=C1)CC(=O)NC2=CC=C(CCCCC3=NN=C(NC(=O)CC4=CC=CC=N4)S3)N=N2",5.597,8,2,13]
["S7664","GSK2578215A","b6","L9900-05","in 10mM DMSO","LRRK2","Autophagy","GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.",399.42,"1285515-21-0",{"v":79,"d":"79.00"},197.79,"<1","N/A","http://selleckchem.com/products/gsk2578215a.html","C24H18FN3O2","free base","N/A","FC1=NC=CC(=C1)C2=CC(=C(OCC3=CC=CC=C3)C=C2)C(=O)NC4=CC=CN=C4",3.985,4,1,6]
["S7683","PIK-III","c6","L9900-05","in 10mM DMSO","Autophagy,LC3,PI3K","Autophagy","PIK-III (VPS34-IN2), which is a selective inhibitor of ​VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.",319.36,"1383716-40-2",{"v":63,"d":"63.00"},197.27,"<1","N/A","http://selleckchem.com/products/pik-iii.html","C17H17N7","free base","VPS34-IN2","NC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC=C4",{"v":2.2,"d":"2.200"},5,2,5]
["S7723","PRIMA-1","d6","L9900-05","in 10mM DMSO","p53","Apoptosis","PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.",185.22,"5608-24-2",{"v":37,"d":"37.00"},199.76,{"v":37,"d":"37.00"},199.76,"http://selleckchem.com/products/prima-1.html","C9H15NO3","free base","2,2-Bis(hydroxymethyl)-3-quinuclidinone","OCC1(CO)N2CCC(CC2)C1=O",-0.772,1,2,2]
["S7724","Eprenetapopt (APR-246)","e6","L9900-05","in 10mM DMSO","Apoptosis related,Autophagy,p53","Apoptosis","Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. APR-246 induces apoptosis and autophagy.",199.25,"5291-32-7",{"v":40,"d":"40.00"},200.75,"N/A","N/A","http://selleckchem.com/products/apr-246-prima-1met.html","C10H17NO3","free base","PRIMA-1MET","COCC1(CO)N2CCC(CC2)C1=O",-0.364,2,1,3]
["S7740","SAR-020106","f6","L9900-05","in 10mM DMSO","Chk","Cell Cycle","SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM.",382.85,"1184843-57-9",{"v":20,"d":"20.00"},52.24,"<1","N/A","http://selleckchem.com/products/sar-020106.html","C19H19ClN6O","free base","N/A","CC(CN(C)C)OC1=C(N=CC(=N1)NC2=NC=C3C(=CC=CC3=C2)Cl)C#N",3.925,4,1,6]
["S7747","Ro-3306","g6","L9900-05","in 10mM DMSO","Apoptosis related,Bcl-2,CDK","Cell Cycle","RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis.",351.45,"872573-93-8",{"v":13,"d":"13.00"},36.99,"<1","N/A","http://selleckchem.com/products/ro-3306.html","C18H13N3OS2","free base","N/A","O=C1N=C(NCC2=CC=CS2)S\\C1=C/C3=CC=C4N=CC=CC4=C3",3.712,3,1,4]
["S7753","BPTES","h6","L9900-05","in 10mM DMSO","Glutaminase","Proteases","BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.",524.68,"314045-39-1",{"v":100,"d":"100.00"},190.59,"<1","N/A","http://selleckchem.com/products/bptes.html","C24H24N6O2S3","free base","N/A","O=C(CC1=CC=CC=C1)NC2=NN=C(CCSCCC3=NN=C(NC(=O)CC4=CC=CC=C4)S3)S2",3.432,6,2,12]
["S7781","Sunitinib (SU11248)","a7","L9900-05","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,IRE1,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.",398.47,"557795-19-4",{"v":25,"d":"25.00"},62.74,"<1","N/A","http://selleckchem.com/products/sunitinib.html","C22H27FN4O2","free base","SU11248","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=C2C=C(F)C=C3",2.997,2,3,7]
["S7787","Docetaxel Trihydrate","b7","L9900-05","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",861.93,"148408-66-6",{"v":100,"d":"100.00"},116.02,"<1","N/A","http://selleckchem.com/products/docetaxel-trihydrate.html","C43H53NO14.3H2O","Trihydrate","RP56976 (NSC 628503) Trihydrate","O.O.O.CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",1.964,10,4,13]
["S7849","BDA-366","c7","L9900-05","in 10mM DMSO","Bcl-2","Apoptosis","BDA-366 is a small-molecule Bcl2-BH4 domain antagonist and binds BH4 with high affinity and selectivity. It directly binds to Bcl2 with high binding affinity (Ki =3.3 ± 0.73 nM).",{"v":423.5,"d":"423.50"},"1909226-00-1",{"v":84,"d":"84.00"},198.35,"<1","N/A","http://selleckchem.com/products/bda-366.html","C24H29N3O4","free base","N/A","CCN(CC)CC(O)CNC1=CC=C(NCC2CO2)C3=C1C(=O)C4=CC=CC=C4C3=O",2.467,3,3,10]
["S7867","Oleuropein","d7","L9900-05","in 10mM DMSO","Anti-infection,Apoptosis related,Aromatase,PPAR","Immunology & Inflammation","Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.",540.51,"32619-42-4",{"v":100,"d":"100.00"},185.01,{"v":100,"d":"100.00"},185.01,"http://selleckchem.com/products/oleuropein.html","C25H32O13","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)\\C(=C\\C)C1CC(=O)OCCC3=CC(=C(O)C=C3)O",0.166,7,6,11]
["S7885","SBI-0206965","e7","L9900-05","in 10mM DMSO","Apoptosis related,Autophagy,ULK","Autophagy","SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells.",489.32,"1884220-36-3",{"v":97,"d":"97.00"},198.23,"<1","N/A","http://selleckchem.com/products/sbi-0206965.html","C21H21BrN4O5","free base","N/A","CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(OC)C(=C3)OC)OC",4.128,7,2,8]
["S7888","Spautin-1","f7","L9900-05","in 10mM DMSO","Apoptosis related,Autophagy,DUB","Autophagy","Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.",271.26,"1262888-28-7",{"v":54,"d":"54.00"},199.07,"<1","N/A","http://selleckchem.com/products/spautin-1.html","C15H11F2N3","free base","N/A","FC1=CC=C(CNC2=NC=NC3=CC=C(F)C=C23)C=C1",{"v":3.73,"d":"3.730"},2,1,3]
["S7900","SW033291","g7","L9900-05","in 10mM DMSO","Dehydrogenase","Metabolism","SW033291 is a selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with IC50 and Ki of 1.5 nM and 0.1 nM, respectively.",412.59,"459147-39-8",{"v":83,"d":"83.00"},201.17,"<1","N/A","http://selleckchem.com/products/sw033291.html","C21H20N2OS3","free base","N/A","CCCC[S](=O)C1=C(N)C2=C(C=C(N=C2S1)C3=CC=CS3)C4=CC=CC=C4",5.295,2,1,6]
["S7913","MCB-613","h7","L9900-05","in 10mM DMSO","ROS","ER stress & UPR","MCB-613 is a potent steroid receptor coactivator (SRC) stimulator.",304.39,"1162656-22-5",{"v":60,"d":"60.00"},197.12,"<1","N/A","http://selleckchem.com/products/mcb-613.html","C20H20N2O","free base","N/A","CCC1C\\C(=C/C2=CC=CN=C2)C(=O)C(/C1)=C/C3=CN=CC=C3",3.544,3,0,3]
["S7928","DASA-58","a8","L9900-05","in 10mM DMSO","PKM","Metabolism","DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.",453.53,"1203494-49-8",{"v":91,"d":"91.00"},200.65,"<1","N/A","http://selleckchem.com/products/dasa-58.html","C19H23N3O6S2","free base","N/A","NC1=CC(=CC=C1)[S](=O)(=O)N2CCCN(CC2)[S](=O)(=O)C3=CC4=C(OCCO4)C=C3",0.632,6,1,4]
["S7941","NCT-501","b8","L9900-05","in 10mM DMSO","Dehydrogenase","Metabolism","NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.",416.52,"1802088-50-1",{"v":32,"d":"32.00"},76.83,"<1","N/A","http://selleckchem.com/products/nct-501.html","C21H32N6O3","free base","N/A","CC(C)CC[N]1C(=NC2=C1C(=O)N(C)C(=O)N2C)CN3CCN(CC3)C(=O)C4CC4",1.722,4,0,6]
["S7948","MRT67307 HCl","c8","L9900-05","in 10mM DMSO","Autophagy,IκB/IKK,TBK1,ULK","NF-κB","MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.","464.6 (free-base)","1781882-89-0",{"v":92,"d":"92.00"},198.02,{"v":92,"d":"92.00"},198.02,"https://www.selleckchem.com/products/mrt67307-hcl.html","C26H36N6O2.xHCl","hydrochloride","N/A","O=C(NCCCNC1=NC(=NC=C1C2CC2)NC3=CC(=CC=C3)CN4CCOCC4)C5CCC5",4.257,4,3,11]
["S7949","MRT68921 HCl","d8","L9900-05","in 10mM DMSO","Autophagy,ULK","Autophagy","MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.","434.58 (free base)","2070014-87-6",{"v":10,"d":"10.00"},23.01,"<1","N/A","http://selleckchem.com/products/mrt68921.html","C25H34N6O.xHCl","hydrochloride","N/A","CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C4CC4)C(=N3)NCCCNC(=O)C5CCC5",4.644,3,3,9]
["S7968","P7C3","e8","L9900-05","in 10mM DMSO","NAMPT","Metabolism","P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.",474.19,"301353-96-8",{"v":95,"d":"95.00"},200.34,"<1","N/A","http://selleckchem.com/products/p7c3.html","C21H18Br2N2O","free base","N/A","OC(CNC1=CC=CC=C1)C[N]2C3=C(C=C(Br)C=C3)C4=C2C=CC(=C4)Br",5.972,0,2,5]
["S7999","SKF96365","f8","L9900-05","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.",402.91,"130495-35-1",{"v":80,"d":"80.00"},198.56,{"v":80,"d":"80.00"},198.56,"http://selleckchem.com/products/skf96365.html","C22H26N2O3.HCl","hydrochloride","N/A","Cl.COC1=CC=C(CCCOC(C[N]2C=CN=C2)C3=CC=C(OC)C=C3)C=C1",4.114,4,0,10]
["S8000","Tenovin-1","g8","L9900-05","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).",369.48,"380315-80-0",{"v":74,"d":"74.00"},200.28,"<1","N/A","http://selleckchem.com/products/tenovin-1.html","C20H23N3O2S","free base","N/A","CC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",4.287,2,3,6]
["S8016","Vonoprazan Fumarate (TAK-438)","h8","L9900-05","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.",461.46,"1260141-27-2",{"v":62,"d":"62.00"},134.36,"<1","N/A","http://selleckchem.com/products/tak-438.html","C17H16FN3O2S.C4H4O4","Fumarate","N/A","CNCC1=C[N](C(=C1)C2=CC=CC=C2F)[S](=O)(=O)C3=CC=CN=C3.OC(=O)\\C=C\\C(O)=O",0.017,5,1,7]
["S8037","Necrostatin-1","a9","L9900-05","in 10mM DMSO","Apoptosis related,Autophagy,IDO/TDO,RIP kinase,TNF-alpha","Apoptosis","Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.",259.33,"4311-88-0",{"v":51,"d":"51.00"},196.66,"<1","N/A","http://selleckchem.com/products/necrostatin-1.html","C13H13N3OS","free base","Nec-1","CN1C(=O)C(CC2=C[NH]C3=CC=CC=C23)NC1=S",2.472,1,2,2]
["S8047","Dynasore","b9","L9900-05","in 10mM DMSO","Autophagy,Dynamin,HSV","Cytoskeletal Signaling","Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV).",322.31,"304448-55-3",{"v":64,"d":"64.00"},198.57,"<1","N/A","http://selleckchem.com/products/dynasore.html","C18H14N2O4","free base","N/A","OC1=C(O)C=C(C=C1)\\C=N\\NC(=O)C2=C(O)C=C3C=CC=CC3=C2",2.865,2,4,3]
["S8048","Venetoclax (ABT-199)","c9","L9900-05","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.",868.44,"1257044-40-8",{"v":100,"d":"100.00"},115.15,"<1","N/A","http://selleckchem.com/products/abt-199.html","C45H50ClN7O7S","free base","GDC-0199","CC1(C)CCC(=C(C1)C2=CC=C(Cl)C=C2)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)N[S](=O)(=O)C5=CC=C(NCC6CCOCC6)C(=C5)[N+]([O-])=O)OC7=CN=C8[NH]C=CC8=C7",{"v":7.94,"d":"7.940"},6,3,13]
["S8061","Sabutoclax","d9","L9900-05","in 10mM DMSO","Bcl-2","Apoptosis","Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50  of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.",700.78,"1228108-65-3",{"v":100,"d":"100.00"},{"v":142.7,"d":"142.70"},"<1","N/A","http://selleckchem.com/products/sabutoclax.html","C42H40N2O8","free base","BI-97C1","CC(CNC(=O)C1=C(O)C(=CC2=C1C=C(C)C(=C2O)C3=C(O)C4=CC(=C(O)C(=C4C=C3C)C(=O)NCC(C)C5=CC=CC=C5)O)O)C6=CC=CC=C6",7.549,2,8,9]
["S8065","Nutlin-3b","e9","L9900-05","in 10mM DMSO","MDM2/MDMX","Apoptosis","Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.",581.49,"675576-97-3",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/nutlin-3b.html","C30H30Cl2N4O4","free base","(+)-Nutlin-3","COC1=CC=C(C(=C1)OC(C)C)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5",5.434,5,1,6]
["S8101","CB-5083","f9","L9900-05","in 10mM DMSO","ATPase,p97","Transmembrane Transporters","CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.",413.47,"1542705-92-9",{"v":82,"d":"82.00"},198.32,"<1","N/A","http://selleckchem.com/products/cb-5083.html","C24H23N5O2","free base","N/A","CC1=CC2=C(C=CC=C2C(N)=O)[N]1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5",3.748,4,2,5]
["S8106","NSC59984","g9","L9900-05","in 10mM DMSO","p53","Apoptosis","NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.",265.27,"803647-40-7",{"v":53,"d":"53.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/nsc59984.html","C12H15N3O4","free base","N/A","CN1CCN(CC1)C(=O)\\C=C\\C2=CC=C(O2)[N+]([O-])=O",1.083,2,0,3]
["S8117","GMX1778 (CHS828)","h9","L9900-05","in 10mM DMSO","Apoptosis related,NAMPT","Metabolism","GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1.",371.86,"200484-11-3",{"v":74,"d":"74.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/gmx1778-chs828.html","C19H22ClN5O","free base","N/A","ClC1=CC=C(OCCCCCCNC(NC2=CC=NC=C2)=NC#N)C=C1",{"v":3.84,"d":"3.840"},3,2,11]
["S8149","NSC348884","a10","L9900-05","in 10mM DMSO","Apoptosis related,p53","Apoptosis","NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.",636.79,"81624-55-7",{"v":100,"d":"100.00"},157.04,"<1","N/A","http://selleckchem.com/products/nsc348884.html","C38H40N10","free base","N/A","CC1=CC2=C(C=C1)N=C(CN(CCN(CC3=NC4=C([NH]3)C=C(C)C=C4)CC5=NC6=C([NH]5)C=C(C)C=C6)CC7=NC8=C([NH]7)C=C(C)C=C8)[NH]2",7.572,4,4,11]
["S8177","BH3I-1","b10","L9900-05","in 10mM DMSO","Bcl-2","Apoptosis","BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins.",400.31,"300817-68-9",{"v":64,"d":"64.00"},159.88,"<1","N/A","http://selleckchem.com/products/bh3i-1.html","C15H14BrNO3S2","free base","N/A","CC(C)C(N1C(=S)S\\C(=C/C2=CC=C(Br)C=C2)C1=O)C(O)=O",4.604,2,0,4]
["S8182","NSC87877","c10","L9900-05","in 10mM DMSO","phosphatase","Metabolism","NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.",503.42,"56932-43-5",{"v":100,"d":"100.00"},198.64,{"v":100,"d":"100.00"},198.64,"http://selleckchem.com/products/nsc87877.html","C19H13N3O7S2.2Na","sodium salt","N/A","OC1=C2N=CC=CC2=C(C=C1N=NC3=CC4=CC=C(C=C4C=C3)[S](=O)(=O)O[Na])[S](=O)(=O)O[Na]",3.899,5,1,6]
["S8205","Enasidenib (AG-221)","d10","L9900-05","in 10mM DMSO","Dehydrogenase","Metabolism","Enasidenib (AG-221) is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzyme.",473.38,"1446502-11-9",{"v":94,"d":"94.00"},198.57,"<1","N/A","http://selleckchem.com/products/ag-221-enasidenib.html","C19H17F6N7O","free base","N/A","CC(C)(O)CNC1=NC(=NC(=N1)NC2=CC=NC(=C2)C(F)(F)F)C3=NC(=CC=C3)C(F)(F)F",4.878,5,2,8]
["S8206","Ivosidenib (AG-120)","e10","L9900-05","in 10mM DMSO","Dehydrogenase","Metabolism","Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.",582.96,"1448347-49-6",{"v":100,"d":"100.00"},171.54,"<1","N/A","http://selleckchem.com/products/ag-120-Ivosidenib.html","C28H22ClF3N6O3","free base","N/A","FC1=CN=CC(=C1)N(C(C(=O)NC2CC(F)(F)C2)C3=C(Cl)C=CC=C3)C(=O)C4CCC(=O)N4C5=NC=CC(=C5)C#N",3.004,5,1,7]
["S8276","FCCP","f10","L9900-05","in 10mM DMSO","ATPase,OXPHOS","Apoptosis","FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.",254.17,"370-86-5",{"v":50,"d":"50.00"},196.72,"<1","N/A","http://selleckchem.com/products/fccp.html","C10H5F3N4O","free base","Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone","FC(F)(F)OC1=CC=C(NN=C(C#N)C#N)C=C1",3.924,2,1,4]
["S8279","(±)-Shikonin","g10","L9900-05","in 10mM DMSO","Anti-infection,Chloride Channel,COVID-19,NF-κB,PKM,Proteasome,TNF-alpha","Metabolism","(±)-Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.",{"v":288.3,"d":"288.30"},"54952-43-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/shikonin.html","C16H16O5","free base","Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844","CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O",2.444,2,3,3]
["S8299","HA15","h10","L9900-05","in 10mM DMSO","HSP (HSP90)","ER stress & UPR","HA15 is a molecule that targets specifically HSPA5 (Heat shock 70kDa protein 5) also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.",466.58,"1609402-14-3",{"v":93,"d":"93.00"},199.32,"<1","N/A","http://selleckchem.com/products/ha15.html","C23H22N4O3S2","free base","N/A","CN(C)C1=CC=CC2=C1C=CC=C2[S](=O)(=O)NC3=CC(=CC=C3)C4=CSC(=N4)NC(C)=O",3.452,4,2,6]
["S8304","Azoramide","a11","L9900-05","in 10mM DMSO","PERK","Apoptosis","Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.",308.83,"932986-18-0",{"v":61,"d":"61.00"},197.52,"<1","N/A","http://selleckchem.com/products/azoramide.html","C15H17ClN2OS","free base","N/A","CCCC(=O)NCCC1=CSC(=N1)C2=CC=C(Cl)C=C2",3.588,2,1,6]
["S8365","Apoptozole","b11","L9900-05","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Apoptozole (Apoptosis Activator VII) is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.",625.56,"1054543-47-3",{"v":100,"d":"100.00"},159.86,"<1","N/A","http://selleckchem.com/products/apoptozole.html","C33H25F6N3O3","free base","Apoptosis Activator VII","COC1=CC=C(C=C1)C2=C([N](CC3=CC=C(C=C3)C(N)=O)C(=N2)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=CC=C(OC)C=C5",8.042,4,1,10]
["S8376","Rbin-1","c11","L9900-05","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.",256.33,"328023-11-6",{"v":23,"d":"23.00"},89.73,"<1","N/A","http://selleckchem.com/products/rbin-1.html","C13H12N4S","free base","Ribozinoindole-1","CC(=C)CSC1=NC2=C(N=N1)C3=CC=CC=C3[NH]2",{"v":3.83,"d":"3.830"},3,1,3]
["S8382","ML390","d11","L9900-05","in 10mM DMSO","Dehydrogenase","Metabolism","ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.",{"v":406.4,"d":"406.40"},"2029049-79-2",{"v":81,"d":"81.00"},199.31,"<1","N/A","http://selleckchem.com/products/ml390.html","C21H21F3N2O3","free base","N/A","FC(F)(F)OC1=CC=C(C=C1)C(=O)NCCC(=O)NC2CCCC3=C2C=CC=C3",5.065,3,2,7]
["S8405","RRx-001","e11","L9900-05","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. RRx-001 triggers apoptosis and exhibits anticancer activity.",268.02,"925206-65-1",{"v":53,"d":"53.00"},197.75,"<1","N/A","http://selleckchem.com/products/rrx-001.html","C5H6BrN3O5","free base","N/A","[O-][N+](=O)C1(CN(C1)C(=O)CBr)[N+]([O-])=O",0.473,1,0,3]
["S8444","KPT 9274 ( ATG-019)","f11","L9900-05","in 10mM DMSO","NAMPT,PAK","Metabolism","KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.",610.62,"1643913-93-2",{"v":100,"d":"100.00"},163.77,"<1","N/A","http://selleckchem.com/products/kpt-9274.html","C35H29F3N4O3","free base","N/A","NC1=NC=C(C=C1)\\C=C\\C(=O)NCC2=CC3=C(O2)C(=CC(=C3)C4=CC=C(C=C4)C(=O)N5CCC(F)(F)CC5)C6=CC=C(F)C=C6",{"v":5.59,"d":"5.590"},4,2,7]
["S8483","CBL0137 HCl","g11","L9900-05","in 10mM DMSO","NF-κB,p53","Apoptosis","CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).",372.89,"1197397-89-9",{"v":38,"d":"38.00"},101.91,{"v":24,"d":"24.00"},64.36,"http://selleckchem.com/products/cbl0137-cbl-0137.html","C21H24N2O2.HCl","HCl","CBLC137 HCl, Curaxin 137 HCl","Cl.CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",{"v":3.72,"d":"3.720"},2,1,6]
["S8558","Tofogliflozin(CSG 452)","h11","L9900-05","in 10mM DMSO","SGLT","GPCR & G Protein","Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.",404.45,"1201913-82-7",{"v":84,"d":"84.00"},207.69,{"v":4,"d":"4.00"},9.89,"http://selleckchem.com/products/tofogliflozin-csg-452.html","C22H26O6.H2O","hydrate","N/A","O.CCC1=CC=C(CC2=CC3=C(COC34OC(CO)C(O)C(O)C4O)C=C2)C=C1",{"v":1.92,"d":"1.920"},2,4,4]
["S8580","COTI-2","a2","L9900-06","in 10mM DMSO","p53","Apoptosis","COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.",366.48,"1039455-84-9",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/coti-2.html","C19H22N6S","free base","N/A","S=C(N\\N=C/1CCCC2=C1N=CC=C2)N3CCN(CC3)C4=NC=CC=C4",3.825,3,1,4]
["S8597","LYN-1604","b2","L9900-06","in 10mM DMSO","Autophagy,ULK","Autophagy","LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.",657.54,"2088939-99-3",{"v":50,"d":"50.00"},76.04,{"v":100,"d":"100.00"},152.08,"http://selleckchem.com/products/lyn-1604.html","C33H45Cl4N3O2","dihydrochloride","N/A","Cl.Cl.CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(OCC2=CC=C3C=CC=CC3=C2)C4=CC=C(Cl)C=C4Cl",7.992,2,0,12]
["S8611","Vorasidenib (AG-881)","c2","L9900-06","in 10mM DMSO","Dehydrogenase","Metabolism","Vorasidenib (AG-881) is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2).",414.74,"1644545-52-7",{"v":82,"d":"82.00"},197.71,"<1","N/A","http://selleckchem.com/products/ag-881.html","C14H13ClF6N6","free base","N/A","CC(NC1=NC(=NC(=N1)C2=CC=CC(=N2)Cl)NC(C)C(F)(F)F)C(F)(F)F",5.146,4,2,7]
["S8615","Sodium dichloroacetate (DCA)","d2","L9900-06","in 10mM DMSO","Apoptosis related,Dehydrogenase,NKCC,ROS","Metabolism","Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.",150.92,"2156-56-1",{"v":30,"d":"30.00"},198.78,{"v":30,"d":"30.00"},198.78,"http://selleckchem.com/products/sodium-dichloroacetate-dca.html","C2HCl2O2.Na","sodium salt","Dichloroacetic acid, bichloroacetic acid, BCA","[Na]OC(=O)C(Cl)Cl",1.081,2,0,2]
["S8616","PKM2 inhibitor(compound 3k)","e2","L9900-06","in 10mM DMSO","PKM","Metabolism","PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.",345.48,"94164-88-2",{"v":6,"d":"6.00"},17.37,"<1","N/A","http://selleckchem.com/products/pkm2-inhibitor-compound-3k.html","C18H19NO2S2","free base","PKM2-IN-1","CC1=C(CSC(=S)N2CCCCC2)C(=O)C3=CC=CC=C3C1=O",5.039,2,0,4]
["S8619","NCT-503","f2","L9900-06","in 10mM DMSO","Dehydrogenase","Metabolism","NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with the IC50 value of 2.5 μM. It is inactive against a panel of other dehydrogenases and shows minimal cross-reactivity in a panel of 168 GPCRs.",408.48,"1916571-90-8",{"v":81,"d":"81.00"},{"v":198.3,"d":"198.30"},"<1","N/A","http://selleckchem.com/products/nct-503.html","C20H23F3N4S","free base","N/A","CC1=CC(=NC(=C1)C)NC(=S)N2CCN(CC2)CC3=CC=C(C=C3)C(F)(F)F",5.688,1,1,6]
["S8639","Diphenyleneiodonium chloride (DPI)","g2","L9900-06","in 10mM DMSO","NADPH-oxidase,NOS,ROS,TRP Channel","Immunology & Inflammation","Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).",314.55,"4673-26-1",{"v":13,"d":"13.00"},41.33,"<1","N/A","http://selleckchem.com/products/diphenyleneiodonium-chloride-dpi.html","C12H8I.Cl","chloride","N/A","[Cl-].[I+]1C2=CC=CC=C2C3=C1C=CC=C3",1.101,0,0,0]
["S8650","BTSA1","h2","L9900-06","in 10mM DMSO","Bcl-2","Apoptosis","BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.",430.51,"314761-14-3",{"v":81,"d":"81.00"},188.15,"<1","N/A","http://selleckchem.com/products/btsa1.html","C21H14N6OS2","free base","N/A","O=C1N(N=C(C2=CC=CC=C2)\\C1=N/NC3=NC=CS3)C4=NC(=CS4)C5=CC=CC=C5",4.439,5,1,5]
["S8661","CA3 (CIL56)","a3","L9900-06","in 10mM DMSO","Ferroptosis,ROS,TEAD,YAP","Hippo","CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).",489.61,"300802-28-2",{"v":97,"d":"97.00"},198.12,"<1","N/A","http://selleckchem.com/products/ca3.html","C23H27N3O5S2","free base","N/A","O/N=C1/C2=CC(=CC=C2C3=C1C=C(C=C3)[S](=O)(=O)N4CCCCC4)[S](=O)(=O)N5CCCCC5",3.058,5,0,4]
["S8728","PK11000","b3","L9900-06","in 10mM DMSO","p53","Apoptosis","PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.",236.63,"38275-34-2",{"v":47,"d":"47.00"},198.62,{"v":47,"d":"47.00"},198.62,"https://www.selleckchem.com/products/pk11000.html","C6H5ClN2O4S","free base","N/A","C[S](=O)(=O)C1=NC=C(Cl)C(=N1)C(O)=O",{"v":0.82,"d":"0.820"},5,0,2]
["S8731","IACS-010759 (IACS-10759)","c3","L9900-06","in 10mM DMSO","OXPHOS","Apoptosis","IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I.",562.56,"1570496-34-2",{"v":27,"d":"27.00"},47.99,"<1","N/A","http://www.selleckchem.com/products/iacs-010759-iacs-10759.html","C25H25F3N6O4S","Free Base","N/A","CC1=NC(=N[N]1CC2=CC(=CC=C2)N3CCC(CC3)[S](C)(=O)=O)C4=NC(=NO4)C5=CC=C(OC(F)(F)F)C=C5",4.909,8,0,8]
["S8759","S55746","d3","L9900-06","in 10mM DMSO","Bcl-2","Apoptosis","S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.",710.82,"1448584-12-0",{"v":100,"d":"100.00"},140.68,"<1","N/A","http://www.selleckchem.com/products/s55746-s055746-bcl201.html","C43H42N4O6","Free Base","S 055746,BCL201","OC1=CC=C(C=C1)N(C(=O)C2=C3CCCC[N]3C(=C2)C4=C(C=C5OCOC5=C4)C(=O)N6CC7=C(CC6CN8CCOCC8)C=CC=C7)C9=CC=CC=C9",6.817,5,1,7]
["S8778","UPGL00004","e3","L9900-06","in 10mM DMSO","Glutaminase","Proteases","UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.",534.66,"1890169-95-5",{"v":25,"d":"25.00"},46.76,"<1","N/A","http://www.selleck.cn/products/upgl00004.html","C25H26N8O2S2","free base","N/A","O=C(CC1=CC=CC=C1)NC2=NN=C(NC3CCN(CC3)C4=NN=C(NC(=O)CC5=CC=CC=C5)S4)S2",3.091,6,3,9]
["S8793","ULK-101","f3","L9900-06","in 10mM DMSO","Autophagy,ULK","Autophagy","ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.",460.45,"2443816-45-1",{"v":92,"d":"92.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleck.cn/products/ulk-101.html","C22H16F4N4OS","Free Base","N/A","FC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CSC(=C4)C(=O)NC(C5CC5)C(F)(F)F",4.363,3,1,6]
["S9021","(20R)Ginsenoside Rg3","g3","L9900-06","in 10mM DMSO","ROS","Immunology & Inflammation","(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.",785.01,"38243-03-7",{"v":10,"d":"10.00"},12.74,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rg3.html","C42H72O13","free base","OG15964","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",2.295,4,8,10]
["S9032","Sanguinarine","h3","L9900-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.",332.33,"2447-54-3",{"v":44,"d":"44.00"},{"v":132.4,"d":"132.40"},"N/A","N/A","https://www.selleckchem.com/products/sanguinarine.html","C20H14NO4","free base","Pseudochelerythrine, Sanguinarin, Sanguinarium","C[N+]1=CC2=C3OCOC3=CC=C2C4=C1C5=CC6=C(OCO6)C=C5C=C4",3.987,4,0,0]
["S9034","Isochlorogenic acid C","a4","L9900-06","in 10mM DMSO","ROS","Immunology & Inflammation","Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.",516.45,"57378-72-0",{"v":10,"d":"10.00"},19.36,"N/A","N/A","https://www.selleckchem.com/products/isochlorogenic-acid-c.html","C25H24O12","free base","3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C1OC(=O)\\C=C\\C3=CC=C(O)C(=C3)O)C(O)=O",1.687,5,5,9]
["S9039","Albiflorin","b4","L9900-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.",480.46,"39011-90-0",{"v":10,"d":"10.00"},20.81,"N/A","N/A","https://www.selleckchem.com/products/albiflorin.html","C23H28O11","free base","OA10410","CC12CC(O)C3CC1(OC4OC(CO)C(O)C(O)C4O)C3(COC(=O)C5=CC=CC=C5)C(=O)O2",-1.333,6,5,7]
["S9046","Berberine","c4","L9900-06","in 10mM DMSO","Bacterial","Microbiology","Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.",336.36,"2086-83-1",{"v":45,"d":"45.00"},133.78,"N/A","N/A","https://www.selleckchem.com/products/berberine.html","C20H18NO4","free base","Umbellatine","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4",3.962,4,0,2]
["S9056","Tuberostemonine","d4","L9900-06","in 10mM DMSO","Others","Others","Tuberostemonine, a natural product found in Stemona phyllantha and Stemona tuberosa, is an alkaloid and a metabolite.",{"v":375.5,"d":"375.50"},"6879-01-2",{"v":75,"d":"75.00"},199.73,"N/A","N/A","https://www.selleckchem.com/products/tuberostemonine.html","C22H33NO4","free base","FT73792","CCC1C2CCCCN3C(CC(C4C(C)C(=O)OC14)C23)C5CC(C)C(=O)O5",3.603,4,0,2]
["S9107","Glycitein","e4","L9900-06","in 10mM DMSO","ROS","Immunology & Inflammation","Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.",284.26,"40957-83-3",{"v":10,"d":"10.00"},35.18,"N/A","N/A","https://www.selleckchem.com/products/glycitein.html","C16H12O5","free base","N/A","COC1=CC2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1O",2.366,3,2,2]
["S9125","Apigetrin","f4","L9900-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.",432.38,"578-74-5",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"N/A","N/A","https://www.selleckchem.com/products/apigetrin.html","C21H20O10","free base","Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.48,"d":"0.480"},4,6,4]
["S9133","Chicoric acid","g4","L9900-06","in 10mM DMSO","Others","Others","Chicoric acid (Dicaffeoyltartaric acid), identified in many plants, exerts various properties include anti-cancer, anti-obesity, antiviral, and anti-diabetic effects.",474.37,"70831-56-0",{"v":94,"d":"94.00"},198.16,"N/A","N/A","https://www.selleckchem.com/products/chicoric-acid.html","C22H18O12","free base","Dicaffeoyltartaric acid","OC(=O)C(OC(=O)\\C=C\\C1=CC(=C(O)C=C1)O)C(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C(O)=O",{"v":2.39,"d":"2.390"},6,4,11]
["S9152","Epiberberine","h4","L9900-06","in 10mM DMSO","Others","Others","Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).",336.36,"6873-09-2",{"v":12,"d":"12.00"},35.68,"N/A","N/A","https://www.selleckchem.com/products/epiberberine.html","C20H18NO4","free base","N/A","COC1=C(OC)C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(OCO5)C4=C3",3.962,4,0,2]
["S9160","Ziyu-glycoside I","a5","L9900-06","in 10mM DMSO","Others","Others","Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics.",766.95,"35286-58-9",{"v":100,"d":"100.00"},130.39,"N/A","N/A","https://www.selleckchem.com/products/ziyu-glycoside-i.html","C41H66O13","free base","N/A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC34C)C2C1(C)O)C(=O)OC7OC(CO)C(O)C(O)C7O",2.178,5,7,6]
["S9162","Rubimaillin","b5","L9900-06","in 10mM DMSO","Acyltransferase","Metabolism","Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and acetyl-CoA cholesterol acyltransferase 2 (ACAT2), but is more selective for the ACAT2 isozyme.",284.31,"55481-88-4",{"v":22,"d":"22.00"},77.38,"N/A","N/A","https://www.selleckchem.com/products/rubimaillin.html","C17H16O4","free base","Mollugin","COC(=O)C1=C(O)C2=C(C=CC=C2)C3=C1C=CC(C)(C)O3",3.139,3,1,2]
["S9163","Rhapontigenin","c5","L9900-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM).",258.27,"500-65-2",{"v":51,"d":"51.00"},197.47,"N/A","N/A","https://www.selleckchem.com/products/rhapontigenin.html","C15H14O4","free base","Protigenin","COC1=CC=C(/C=C/C2=CC(=CC(=C2)O)O)C=C1O",3.073,1,3,3]
["S9174","Xanthotoxol","d5","L9900-06","in 10mM DMSO","5-HT Receptor,Immunology & Inflammation related","Neuronal Signaling","Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.",202.16,"2009-24-7",{"v":40,"d":"40.00"},197.86,"N/A","N/A","https://www.selleckchem.com/products/xanthotoxol.html","C11H6O4","free base","8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen","OC1=C2OC(=O)C=CC2=CC3=C1OC=C3",1.961,3,1,0]
["S9181","Periplocin","e5","L9900-06","in 10mM DMSO","ATPase","Transmembrane Transporters","Periplocin (Periplocoside), extracted from the traditional herbal medicine cortex periplocae, has cardiac and anticancer activity. Periplocin could significantly boost proliferation, migration and stimulate collagen production in fibroblast L929 cells, which is dependent on activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase, and thus promoting wound healing.",696.82,"13137-64-9",{"v":100,"d":"100.00"},143.51,"N/A","N/A","https://www.selleckchem.com/products/periplocin.html","C36H56O13","free base","Periplocoside","COC1CC(OC(C)C1OC2OC(CO)C(O)C(O)C2O)OC3CCC4(C)C5CCC6(C)C(CCC6(O)C5CCC4(O)C3)C7=CC(=O)OC7",0.742,7,4,7]
["S9211","Eriocitrin","f5","L9900-06","in 10mM DMSO","Others","Others","Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity.",596.53,"13463-28-0",{"v":100,"d":"100.00"},167.64,"N/A","N/A","https://www.selleckchem.com/products/eriocitrin.html","C27H32O15","free base","eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside","CC1OC(OCC2OC(OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C(=C5)O)O)C(O)C(O)C2O)C(O)C(O)C1O",-0.657,6,9,6]
["S9234","Schaftoside","g5","L9900-06","in 10mM DMSO","Lipase,MyD88,TLR","Metabolism","Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.",564.49,"51938-32-0",{"v":100,"d":"100.00"},177.15,"N/A","N/A","https://www.selleckchem.com/products/schaftoside.html","C26H28O14","free base","N/A","OCC1OC(C(O)C(O)C1O)C2=C(O)C3=C(OC(=CC3=O)C4=CC=C(O)C=C4)C(=C2O)C5OCC(O)C(O)C5O",-1.862,4,10,4]
["S9276","Alisol B","h5","L9900-06","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.",{"v":472.7,"d":"472.70"},"18649-93-9",{"v":95,"d":"95.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/alisol-b.html","C30H48O4","free base","N/A","CC(CC(O)C1OC1(C)C)C2=C3CC(O)C4C5(C)CCC(=O)C(C)(C)C5CCC4(C)C3(C)CC2",4.782,2,2,4]
["S9282","Isochlorogenic acid A","a6","L9900-06","in 10mM DMSO","Others","Others","Isochlorogenic acid A (3,5-dicaffeoylquinic acid), isolated from Brazilian propolis and Suaeda glauca, exhibits hepatoprotective and cytotoxic activities.",516.45,"2450-53-5",{"v":100,"d":"100.00"},193.63,"N/A","N/A","https://www.selleckchem.com/products/isochlorogenic-acid-a.html","C25H24O12","free base","3,5-dicaffeoylquinic acid","OC1C(CC(O)(CC1OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C(O)=O)OC(=O)\\C=C\\C3=CC(=C(O)C=C3)O",1.687,5,5,9]
["S9286","Neobavaisoflavone","b6","L9900-06","in 10mM DMSO","DNA/RNA Synthesis","Cell Cycle","Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.",322.35,"41060-15-5",{"v":64,"d":"64.00"},198.54,"N/A","N/A","https://www.selleckchem.com/products/neobavaisoflavone.html","C20H18O4","free base","N/A","CC(C)=CCC1=CC(=CC=C1O)C2=COC3=C(C=CC(=C3)O)C2=O",4.239,2,2,3]
["S9301","Verbenalin","c6","L9900-06","in 10mM DMSO","Others","Others","Verbenalin (Verbenalol β-D-glucopyranoside, Verbenalol glucoside, Cornin), an iridoid glycoside found in Verbena officinalis, has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury.",388.37,"548-37-8",{"v":78,"d":"78.00"},200.84,"N/A","N/A","https://www.selleckchem.com/products/verbenalin.html","C17H24O10","free base","Verbenalol β-D-glucopyranoside, Verbenalol glucoside, Cornin","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)CC(=O)C13",-1.937,6,4,5]
["S9302","Polyphyllin VI","d6","L9900-06","in 10mM DMSO","Pyroptosis","Apoptosis","Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.",{"v":738.9,"d":"738.90"},"55916-51-3",{"v":100,"d":"100.00"},135.34,"N/A","N/A","https://www.selleckchem.com/products/polyphyllin-vi.html","C39H62O13","free base","N/A","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3(O)C2C)OC7OC(CO)C(O)C(O)C7OC8OC(C)C(O)C(O)C8O",1.381,6,6,5]
["S9338","Octyl gallate","e6","L9900-06","in 10mM DMSO","Others","Microbiology","Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity.",282.33,"1034-01-1",{"v":56,"d":"56.00"},198.35,"N/A","N/A","https://www.selleckchem.com/products/octyl-gallate.html","C15H22O5","free base","Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester","CCCCCCCCOC(=O)C1=CC(=C(O)C(=C1)O)O",4.112,2,3,9]
["S9341","3,4-Dimethoxycinnamic acid","f6","L9900-06","in 10mM DMSO","Anti-infection","Microbiology","3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.",208.21,"2316-26-9",{"v":42,"d":"42.00"},201.72,"N/A","N/A","https://www.selleckchem.com/products/3-4-dimethoxycinnamic-acid.html","C11H12O4","free base","Caffeic acid dimethyl ether","COC1=CC=C(/C=C/C(O)=O)C=C1OC",1.894,3,0,4]
["S9342","1,4-Naphthoquinone","g6","L9900-06","in 10mM DMSO","Anti-infection","Microbiology","1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.",158.15,"130-15-4",{"v":32,"d":"32.00"},202.34,"N/A","N/A","https://www.selleckchem.com/products/1-4-naphthoquinone.html","C10H6O2","free base","α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone","O=C1C=CC(=O)C2=C1C=CC=C2",1.757,2,0,0]
["S9379","Dihydrocoumarin","h6","L9900-06","in 10mM DMSO","Others","Others","Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps.",148.16,"119-84-6","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/dihydrocoumarin.html","C9H8O2","free base","N/A","O=C1CCC2=C(O1)C=CC=C2",1.923,2,0,0]
["S9401","3,6'-Disinapoyl sucrose","a7","L9900-06","in 10mM DMSO","Others","Others","3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats.",754.69,"139891-98-8",{"v":100,"d":"100.00"},132.51,"N/A","N/A","https://www.selleckchem.com/products/3-6-disinapoyl-sucrose.html","C34H42O19","free base","Disinapoyl sucrose","COC1=CC(=CC(=C1O)OC)\\C=C\\C(=O)OCC2OC(OC3(CO)OC(CO)C(O)C3OC(=O)/C=C/C4=CC(=C(O)C(=C4)OC)OC)C(O)C(O)C2O",0.162,11,8,17]
["S9408","Beta-Elemonic acid","b7","L9900-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.",454.68,"28282-25-9",{"v":35,"d":"35.00"},76.98,"N/A","N/A","https://www.selleckchem.com/products/beta-elemonic.html","C30H46O3","free base","3-Oxotirucallenoic Acid","CC(C)=CCCC(C1CCC2(C)C3=C(CCC12C)C4(C)CCC(=O)C(C)(C)C4CC3)C(O)=O",7.153,2,0,5]
["S9411","Liensinine","c7","L9900-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.",610.74,"2586-96-1",{"v":100,"d":"100.00"},163.74,"N/A","N/A","https://www.selleckchem.com/products/liensinine.html","C37H42N2O6","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(O)C(=C3)OC4=CC5=C(CCN(C)C5CC6=CC=C(O)C=C6)C=C4OC)N(C)CC2",{"v":7.02,"d":"7.020"},4,2,9]
["S9424","Liensinine diperchlorate","d7","L9900-06","in 10mM DMSO","Autophagy,Mitophagy","Autophagy","Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.",811.66,"5088-90-4",{"v":50,"d":"50.00"},{"v":61.6,"d":"61.60"},"N/A","N/A","https://www.selleckchem.com/products/liensinine-diperchlorate.html","C37H44Cl2N2O14","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC(=C(O)C=C3)OC4=C(OC)C=C5CCN(C)C(CC6=CC=C(O)C=C6)C5=C4)N(C)CC2.O[Cl](=O)(=O)=O.O[Cl](=O)(=O)=O",7.669,4,2,9]
["S9431","Dehydrocorydalin","e7","L9900-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.",366.43,"30045-16-0",{"v":73,"d":"73.00"},199.22,"N/A","N/A","https://www.selleckchem.com/products/dehydrocorydalin.html","C22H24NO4","free base","N/A","COC1=CC=C2C(=C3C4=C(CC[N+]3=CC2=C1OC)C=C(OC)C(=C4)OC)C",4.648,4,0,4]
["S9432","Ginkgolic Acid","f7","L9900-06","in 10mM DMSO","Histone Acetyltransferase,SUMO","Ubiquitin","Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).",{"v":346.5,"d":"346.50"},"22910-60-7",{"v":69,"d":"69.00"},199.13,"N/A","N/A","https://www.selleckchem.com/products/ginkgolic-acid-s9432.html","C22H34O3","free base","N/A","CCCCCC\\C=C/CCCCCCCC1=CC=CC(=C1C(O)=O)O",7.646,1,1,14]
["S9562","Pomolic acid","g7","L9900-06","in 10mM DMSO","Apoptosis related","Apoptosis","Pomolic acid is a pentacyclic triterpene isolated from Euscaphis japonica, and is highly effective in inhibiting cell growth and induces apoptosis.",{"v":472.7,"d":"472.70"},"13849-91-7",{"v":10,"d":"10.00"},21.16,{"v":1,"d":"1.00"},2.12,"http://www.selleckchem.com/products/pomolic-acid.html","C30H48O4","Free Base","N/A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1(C)O)C(O)=O",5.344,1,1,1]
["S5850","Vasicine","h7","L9900-06","in 10mM DMSO","AChR","Neuronal Signaling","Vasicine, an alkaloid isolated from A. vasica, is a potential natural cholinesterase inhibitor, exhibits promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer’s disease.",188.23,"6159-55-3",{"v":9,"d":"9.00"},47.81,"<1","N/A","http://www.selleck.cn/products/vasicine.html","C11H12N2O","Free Base","N/A","OC1CCN2CC3=C(C=CC=C3)N=C12",0.514,1,1,0]
["S6540","NG 52","a8","L9900-06","in 10mM DMSO","CDK","Cell Cycle","NG-52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p with IC50s of 7 and 2 μM, respectively.",346.81,"212779-48-1",{"v":69,"d":"69.00"},198.96,"<1","N/A","http://www.selleck.cn/products/ng-52.html","C16H19ClN6O","Free Base","N/A","CC(C)[N]1C=NC2=C1N=C(NCCO)N=C2NC3=CC(=CC=C3)Cl",3.242,3,3,6]
["S6563","DMNQ","b8","L9900-06","in 10mM DMSO","Others","Others","DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.",218.21,"6956-96-3",{"v":44,"d":"44.00"},201.64,"<1","N/A","http://www.selleck.cn/products/dmnq.html","C12H10O4","Free Base","N/A","COC1=C(OC)C(=O)C2=C(C=CC=C2)C1=O",1.133,4,0,2]
["S6602","TB5","c8","L9900-06","in 10mM DMSO","MAO","Metabolism","TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively.",336.25,"948841-07-4",{"v":67,"d":"67.00"},199.26,"<1","N/A","http://www.selleck.cn/products/tb5.html","C15H14BrNOS","Free Base","N/A","CN(C)C1=CC=C(\\C=C\\C(=O)C2=CC=C(Br)S2)C=C1",4.385,1,0,4]
["S6626","Brequinar (DUP785)","d8","L9900-06","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.",375.37,"96187-53-0",{"v":37,"d":"37.00"},98.57,"<1","N/A","http://www.selleck.cn/products/brequinar.html","C23H15F2NO2","Free Base","NSC 368390","CC1=C(N=C2C=CC(=CC2=C1C(O)=O)F)C3=CC=C(C=C3)C4=C(F)C=CC=C4",6.008,2,0,3]
["S6629","GNE-617","e8","L9900-06","in 10mM DMSO","NAMPT","Metabolism","GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.",427.42,"1362154-70-8",{"v":42,"d":"42.00"},98.26,"<1","N/A","http://www.selleck.cn/products/gne-617.html","C21H15F2N3O3S","Free Base","N/A","FC1=CC(=CC(=C1)[S](=O)(=O)C2=CC=C(CNC(=O)C3=C[N]4C=CN=C4C=C3)C=C2)F",2.875,4,1,5]
["S6732","7ACC2","f8","L9900-06","in 10mM DMSO","MCT","Transmembrane Transporters","7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.",309.32,"1472624-85-3",{"v":62,"d":"62.00"},200.44,"<1","N/A","http://www.selleck.cn/products/7acc2.html","C18H15NO4","Free Base","N/A","CN(CC1=CC=CC=C1)C2=CC3=C(C=C2)C=C(C(O)=O)C(=O)O3",3.235,3,0,4]
["S6744","Inauhzin","g8","L9900-06","in 10mM DMSO","Sirtuin","Epigenetics","Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.",469.58,"309271-94-1",{"v":94,"d":"94.00"},200.18,"<1","N/A","http://www.selleck.cn/products/inauhzin.html","C25H19N5OS2","Free Base","N/A","CCC(SC1=NN=C2C(=N1)[NH]C3=C2C=CC=C3)C(=O)N4C5=C(SC6=CC=CC=C46)C=CC=C5",6.482,4,1,4]
["S6748","ML364","h8","L9900-06","in 10mM DMSO","DUB","Ubiquitin","ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.",517.54,"1991986-30-1",{"v":50,"d":"50.00"},96.61,"<1","N/A","http://www.selleck.cn/products/ml364.html","C24H18F3N3O3S2","Free Base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=CC=C2C(=O)NC3=NC(=CS3)C4=CC=CC=C4)C(F)(F)F",5.475,4,2,7]
["S6749","ASP-9521","a9","L9900-06","in 10mM DMSO","Dehydrogenase","Metabolism","ASP-9521 is a selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5).",330.42,"1126084-37-4",{"v":66,"d":"66.00"},199.75,"<1","N/A","http://www.selleck.cn/products/asp-9521.html","C19H26N2O3","Free Base","N/A","COC1=CC2=C([NH]C(=C2)C(=O)N3CCC(CC3)CC(C)(C)O)C=C1",2.794,2,1,4]
["S8820","Unesbulin (PTC596)","b9","L9900-06","in 10mM DMSO","Apoptosis related,Bcl-2,BMI-1","Cell Cycle","Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.",420.34,"1610964-64-1",{"v":84,"d":"84.00"},199.84,"<1","N/A","http://www.selleck.cn/products/ptc596.html","C19H13F5N6","Free Base","N/A","CC1=NC2=CC=C(F)C=C2[N]1C3=NC(=C(F)C(=N3)N)NC4=CC=C(C=C4)C(F)(F)F",5.366,3,2,4]
["S8828","Gboxin","c9","L9900-06","in 10mM DMSO","ATPase,OXPHOS","Apoptosis","Gboxin is an inhibitor of oxidative phosphorylation in cancer cells. Gboxin inhibits the activity of F0F1 ATP synthase. It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.",392.96,"2101315-36-8",{"v":39,"d":"39.00"},99.25,{"v":2,"d":"2.00"},5.09,"http://www.selleck.cn/products/gboxin.html","C22H33ClN2O2","Free Base","N/A","[Cl-].CCC1=[N+](C)C2=CC=CC=C2[N]1CC(=O)OC3CC(C)CCC3C(C)C",3.086,2,0,6]
["S8847","Orludodstat (BAY 2402234)","d9","L9900-06","in 10mM DMSO","Dehydrogenase","Metabolism","Orludodstat (BAY 2402234) is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.",520.84,"2225819-06-5",{"v":100,"d":"100.00"},{"v":192,"d":"192.00"},"<1","N/A","http://www.selleck.cn/products/bay-2402234.html","C21H18ClF5N4O4","Free Base","N/A","CCN1C(=NN(C1=O)C2=C(F)C=C(C(=O)NC3=C(F)C=CC=C3Cl)C(=C2)OC(C)C(F)(F)F)CO",4.103,4,2,8]
["S8865","BAI1","e9","L9900-06","in 10mM DMSO","Bcl-2","Apoptosis","BAI1 is a direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM.",{"v":467.2,"d":"467.20"},"335165-68-9",{"v":18,"d":"18.00"},38.53,"<1","N/A","http://www.selleck.cn/products/bai1.html","C19H21Br2N3O","Free Base","N/A","OC(CN1CCNCC1)C[N]2C3=C(C=C(Br)C=C3)C4=C2C=CC(=C4)Br",4.075,0,2,4]
["S9024","3-O-Acetyl-11-keto-β-boswellic acid (AKBA)","f9","L9900-06","in 10mM DMSO","Lipoxygenase","Metabolism","3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.",512.72,"67416-61-9",{"v":100,"d":"100.00"},195.04,"N/A","N/A","https://www.selleckchem.com/products/akba.html","C32H48O5","Salt","FA42758","CC1CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(C)=O)C(C)(C5CCC34C)C(O)=O)C2C1C",6.081,4,0,3]
["S9086","Dihydrocapsaicin","g9","L9900-06","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.DHC is a selective TRPV1 agonist.",307.43,"19408-84-5",{"v":10,"d":"10.00"},32.53,"N/A","N/A","https://www.selleckchem.com/products/dihydrocapsaicin.html","C18H29NO3","free base","6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589","COC1=C(O)C=CC(=C1)CNC(=O)CCCCCCC(C)C",4.354,2,2,10]
["S9519","Fadrozole (CGS16949A)","h9","L9900-06","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes.",223.27,"102676-47-1",{"v":45,"d":"45.00"},201.55,"<1","N/A","http://www.selleck.cn/products/fadrozole.html","C14H13N3","Free Base","CGS16949A","N#CC1=CC=C(C=C1)C2CCCC3=CN=C[N]23",2.271,1,0,1]
["S9159","momordin-Ic","a10","L9900-06","in 10mM DMSO","SUMO","Ubiquitin","Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.",764.94,"96990-18-0",{"v":100,"d":"100.00"},130.73,"N/A","N/A","https://www.selleckchem.com/products/momordin-ic.html","C41H64O13","free base","N/A","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OC(C(O)C(OC7OCC(O)C(O)C7O)C6O)C(O)=O)C(C)(C)C5CCC34C)C2C1)C(O)=O",3.591,6,5,6]
["S2419","Eprobemide","b10","L9900-06","in 10mM DMSO","MAO","Metabolism","Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.",282.77,"87940-60-1",{"v":57,"d":"57.00"},201.58,"<1","N/A","http://www.selleck.cn/products/eprobemide.html","C14H19ClN2O2","Free Base","Befol, LIS 630","ClC1=CC=C(C=C1)C(=O)NCCCN2CCOCC2",1.591,2,1,5]
["S2935","Nicotinamide Riboside Chloride","c10","L9900-06","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.",{"v":290.7,"d":"290.70"},"23111-00-4",{"v":58,"d":"58.00"},199.52,{"v":58,"d":"58.00"},199.52,"http://www.selleck.cn/products/nicotinamide-riboside-chloride.html","C11H15ClN2O5","Chloride","N/A","[Cl-].NC(=O)C1=CC=C[N+](=C1)C2OC(CO)C(O)C2O",-3.882,2,4,3]
["S6650","EN6","d10","L9900-06","in 10mM DMSO","Autophagy","Autophagy","EN6 is a novel covalent autophagy activator and targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase with an IC50 of 1.7 μM for recombinant human ATP6V1A protein.",368.34,"1808714-73-9",{"v":74,"d":"74.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://www.selleck.cn/products/en6.html","C19H14F2N4O2","Free Base","N/A","FC1=C(NC(=O)C=C)C=C(NC(=O)C2=C[N](N=C2)C3=CC=CC=C3F)C=C1",{"v":3.07,"d":"3.070"},3,2,5]
["S6656","VAS2870","e10","L9900-06","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.",360.39,"722456-31-7",{"v":36,"d":"36.00"},99.89,"<1","N/A","http://www.selleck.cn/products/vas2870.html","C18H12N6OS","Free Base","N/A","C([N]1N=NC2=C1N=CN=C2SC3=NC4=C(O3)C=CC=C4)C5=CC=CC=C5",4.369,6,0,4]
["S6689","Merimepodib","f10","L9900-06","in 10mM DMSO","Dehydrogenase,HCV","Metabolism","Merimepodib (Merimempodib, MMPD, VI-21,497, VX-497) is a potent, specific, and reversible inosine monophosphate dehydrogenase(IMPDH) inhibitor with antiviral activity against hepatitis C virus (HCV) and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent.",452.46,"198821-22-6",{"v":90,"d":"90.00"},198.91,"<1","N/A","http://www.selleck.cn/products/merimepodib.html","C23H24N4O6","Free Base","Merimempodib; MMPD; VI-21,497; VX-497","COC1=CC(=CC=C1C2=CN=CO2)NC(=O)NC3=CC(=CC=C3)CNC(=O)OC4CCOC4",1.762,7,3,8]
["S8812","CM272","g10","L9900-06","in 10mM DMSO","DNA Methyltransferase","Epigenetics","CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death.",478.63,"1846570-31-7",{"v":96,"d":"96.00"},200.57,"<1","N/A","http://www.selleck.cn/products/cm272-cm-272.html","C28H38N4O3","Free Base","N/A","COC1=C(OCCCN2CCCC2)C=C3N=C(C=C(NC4CCN(C)CC4)C3=C1)C5=CC=C(C)O5",4.052,4,1,9]
["S8949","Olutasidenib (FT-2102)","h10","L9900-06","in 10mM DMSO","Dehydrogenase","Metabolism","Olutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21.1 nM, 114 nM for IDH1-R132H, IDH1-R132C, respectively.",354.79,"1887014-12-1",{"v":71,"d":"71.00"},200.12,"<1","N/A","http://www.selleck.cn/products/olutasidenib-ft-2102.html","C18H15ClN4O2","Free Base","N/A","CC(NC1=CC=C(C#N)N(C)C1=O)C2=CC3=C(NC2=O)C=CC(=C3)Cl",1.234,2,2,3]
["S9044","Ginsenoside F2","a11","L9900-06","in 10mM DMSO","Others","Others","Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities.",785.01,"62025-49-4",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://www.selleck.cn/products/ginsenoside-f2.html","C42H72O13","Free Base","N/A","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6O)C(C)(C)C5CCC34C",2.295,4,9,10]
["S9131","Punicalagin","b11","L9900-06","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects., Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.",1084.72,"65995-63-3",{"v":100,"d":"100.00"},92.19,{"v":100,"d":"100.00"},92.19,"http://www.selleck.cn/products/punicalagin.html","C48H28O30","Free Base","N/A","OC1COC(=O)C2=CC(=C(O)C(=C2C3=C4C(=O)OC5=C(O)C(=C(C6=C5C4=C(OC6=O)C(=C3O)O)C7=C(C=C(O)C(=C7O)O)C(=O)OC1C8OC(=O)C9=CC(=C(O)C(=C9C%10=C(C=C(O)C(=C%10O)O)C(=O)OC8C=O)O)O)O)O)O",3.128,13,17,2]
["S9235","Didymin","c11","L9900-06","in 10mM DMSO","p53","Apoptosis","Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.",594.56,"14259-47-3",{"v":100,"d":"100.00"},168.19,{"v":100,"d":"100.00"},168.19,"http://www.selleck.cn/products/didymin.html","C28H34O14","Free Base","Neoponcirin, Isosakuranetin-7-O-rutinoside","COC1=CC=C(C=C1)C2CC(=O)C3=C(O2)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O",-0.189,7,7,7]
["S0096","S-Gboxin","d11","L9900-06","in 10mM DMSO","OXPHOS","Apoptosis","S-Gboxin, a functional analogue of Gboxin, is an oxidative phosphorylation (OXPHOS) inhibitor which inhibits growth of mouse and human glioblastoma (GBM) with IC50 of 470 nM.",600.45,"2101317-21-7",{"v":100,"d":"100.00"},166.54,"˂1","N/A","http://www.selleckchem.com/products/s-gboxin.html","C27H32F3IN2O2","Free Base","N/A","[I-].CC(C)C1CCC(C)CC1OC(=O)C[N]2C3=CC=CC=C3[N+](=C2C4=CC(=CC=C4)C(F)(F)F)C",4.587,2,0,7]
["S0160","Toloxatone (MD69276)","e11","L9900-06","in 10mM DMSO","MAO","Metabolism","Toloxatone (MD69276, Humoryl, Perenum, Umoril) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of  0.93 µM. Toloxatone is an antidepressant agent.",207.23,"29218-27-7",{"v":41,"d":"41.00"},197.85,"˂1","N/A","http://www.selleckchem.com/products/md69276.html","C11H13NO3","Free Base","Humoryl, Perenum, Umoril","CC1=CC=CC(=C1)N2CC(CO)OC2=O",1.593,2,1,2]
["S0209","BVT 2733","f11","L9900-06","in 10mM DMSO","Dehydrogenase","Metabolism","BVT 2733, a new small molecule, is a non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1).",428.96,"376640-41-4",{"v":86,"d":"86.00"},200.48,"˂1","N/A","http://www.selleckchem.com/products/bvt-2733.html","C17H21ClN4O3S2","Free Base","N/A","CN1CCN(CC1)C(=O)CC2=CSC(=N2)N[S](=O)(=O)C3=C(C)C(=CC=C3)Cl",{"v":2.3,"d":"2.300"},4,1,5]
["S0469","ML216","g11","L9900-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively.",383.32,"1430213-30-1",{"v":38,"d":"38.00"},99.13,"˂1","N/A","http://www.selleckchem.com/products/ml216.html","C15H9F4N5OS","Free Base","CID-49852229","FC1=CC=C(NC(=O)NC2=NN=C(S2)C3=CC=NC=C3)C=C1C(F)(F)F",2.919,4,2,4]
["S2427","Triglycidyl Isocyanurate (Teroxirone)","h11","L9900-06","in 10mM DMSO","DNA/RNA Synthesis,p53","Apoptosis","Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.",297.26,"2451-62-9",{"v":59,"d":"59.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/triglycidyl-isocyanurat.html","C12H15N3O6","Free Base","Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC","O=C1N(CC2CO2)C(=O)N(CC3CO3)C(=O)N1CC4CO4",-0.894,6,0,6]
["S6790","Ellipticine hydrochloride","a2","L9900-07","in 10mM DMSO","Others,P450 (e.g. CYP17),Topoisomerase","Metabolism","Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.",282.77,"5081-48-1",{"v":3,"d":"3.00"},10.61,"˂1","N/A","http://www.selleckchem.com/products/ellipticine-hydrochloride.html","C17H15ClN2","Hydrochloride","NSC 71795 hydrochloride, PZE","Cl.CC1=C2C=CN=CC2=C(C)C3=C1[NH]C4=CC=CC=C34",4.435,1,1,0]
["S6815","CDN1163","b2","L9900-07","in 10mM DMSO","ATPase","Transmembrane Transporters","CDN1163 is a small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) that improves Ca2+ homeostasis.",320.39,"892711-75-0",{"v":64,"d":"64.00"},199.76,"<1","N/A","http://www.selleckchem.com/products/cdn1163.html","C20H20N2O2","Free Base","N/A","CC(C)OC1=CC=C(C=C1)C(=O)NC2=CC=CC3=CC=C(C)N=C23",3.793,3,1,4]
["S7821","Bufalin","c2","L9900-07","in 10mM DMSO","ATPase,Others","Transmembrane Transporters","Bufalin (BF) is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity.",386.52,"465-21-4",{"v":78,"d":"78.00"},{"v":201.8,"d":"201.80"},"˂1","N/A","http://www.selleckchem.com/products/bufalin.html","C24H34O4","Free Base","BF","CC12CCC(O)CC1CCC3C2CCC4(C)C(CCC34O)C5=COC(=O)C=C5",3.313,2,1,1]
["S8943","VLX600","d2","L9900-07","in 10mM DMSO","Autophagy,Mitochondrial Metabolism,OXPHOS","Apoptosis","VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS), potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 induces autophagy and mitochondrial inhibition with antitumor activity.",317.35,"327031-55-0",{"v":13,"d":"13.00"},40.96,"˂1","N/A","http://www.selleckchem.com/products/vlx600.html","C17H15N7","Free Base","N/A","CC1=C2[NH]C3=NC(=NN=C3C2=CC=C1)N\\N=C(C)/C4=CC=CC=N4",3.589,5,2,3]
["S8970","HQNO","e2","L9900-07","in 10mM DMSO","Others","Metabolism","HQNO (2-heptyl-4-hydroxyquinoline-N-oxide) is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione.",259.34,"341-88-8",{"v":9,"d":"9.00"},{"v":34.7,"d":"34.70"},"<1","N/A","http://www.selleckchem.com/products/hqno.html","C16H21NO2","Free Base","2-heptyl-4-hydroxyquinoline-N-oxide","CCCCCCCC1=CC(=O)C2=CC=CC=C2N1O",4.709,1,0,6]
["S8980","SBI-797812","f2","L9900-07","in 10mM DMSO","NAMPT","Metabolism","SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a \"super catalyst\" that more efficiently generates NMN.",402.47,"2237268-08-3",{"v":80,"d":"80.00"},198.77,"<1","N/A","http://www.selleckchem.com/products/sbi-797812.html","C19H22N4O4S","Free Base","N/A","O=C(NCC1=CC=NC=C1)NC2=CC=C(C=C2)[S](=O)(=O)N3CC4CCC(C3)O4",0.702,5,2,5]
["S0178","GLX351322","g2","L9900-07","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.",431.51,"835598-94-2",{"v":20,"d":"20.00"},46.35,"<1","N/A","http://www.selleckchem.com/products/glx351322.html","C21H25N3O5S","free base","N/A","CCOC(=O)C1=C(NC(=O)CN2CCN(CC2)C(=O)C3=CC=CO3)SC4=C1CCC4",{"v":2.15,"d":"2.150"},5,1,7]
["S0219","ML241 hydrochloride","h2","L9900-07","in 10mM DMSO","ATPase","Transmembrane Transporters","ML241 hydrochloride is a potent and selective inhibitor of p97 with IC50 of 0.11 μM and 3.5 μM for p97 ATPase and UbG76V–GFP, respectively.",408.92,"2070015-13-1",{"v":74,"d":"74.00"},180.96,"<1","N/A","http://www.selleckchem.com/products/ml-241-hcl.html","C23H25ClN4O","free base","N/A","Cl.C1CCC2=C(NCC3=CC=CC=C3)N=C(N=C2C1)N4CCOC5=C4C=CC=C5",5.964,3,1,4]
["S0507","CBL0137","a3","L9900-07","in 10mM DMSO","NF-κB,p53","NF-κB","CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.",336.43,"1197996-80-7",{"v":15,"d":"15.00"},44.59,"<1","N/A","http://www.selleckchem.com/products/cbl-0137.html","C21H24N2O2","free base","Curaxin-137, CBL-C137, CBLC137","CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",3.338,2,1,6]
["S0777","Isuzinaxib (APX-115 free base)","b3","L9900-07","in 10mM DMSO","CCR,Interleukins,NADPH-oxidase,TNF-alpha","Immunology & Inflammation","Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.",279.34,"1270084-92-8",{"v":56,"d":"56.00"},200.47,"<1","N/A","http://www.selleckchem.com/products/apx-115-free-base.html","C17H17N3O","free base","Ewha-18278 free base","CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3",2.994,2,1,4]
["S0790","CADD522","c3","L9900-07","in 10mM DMSO","RUNX","Cell Cycle","CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA binding with IC50 of 10 nM. CADD522 exhibits anticancer activity.",326.17,"199735-88-1",{"v":65,"d":"65.00"},199.28,"<1","N/A","http://www.selleckchem.com/products/cadd522.html","C15H13Cl2NO3","free base","N/A","OC(=O)C1C2CC(C=C2)C1C(=O)NC3=CC(=C(Cl)C=C3)Cl",2.821,2,1,3]
["S0819","BL-918","d3","L9900-07","in 10mM DMSO","ULK","Autophagy","BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1) with EC50 of 24.14 nM and Kd of 0.719 μM. BL-918 induces cytoprotective autophagy for Parkinson's disease treatment.",533.44,"2101517-69-3",{"v":100,"d":"100.00"},187.46,"<1","N/A","http://www.selleckchem.com/products/bl-918.html","C23H15F8N3OS","free base","N/A","FC1=CC(=C(NC(=O)C(NC(=S)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3=CC=CC=C3)C=C1)F",7.163,1,3,9]
["S1001","Navitoclax (ABT-263)","e3","L9900-07","in 10mM DMSO","Bcl-2","Apoptosis","Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.",974.61,"923564-51-6",{"v":100,"d":"100.00"},102.61,"<1","N/A","http://www.selleckchem.com/products/ABT-263.html","C47H55ClF3N5O6S3","free base","N/A","CC1(C)CCC(=C(CN2CCN(CC2)C3=CC=C(C=C3)C(=O)N[S](=O)(=O)C4=CC(=C(NC(CCN5CCOCC5)CSC6=CC=CC=C6)C=C4)[S](=O)(=O)C(F)(F)F)C1)C7=CC=C(Cl)C=C7",10.495,6,2,17]
["S2176","Tenovin-3","f3","L9900-07","in 10mM DMSO","p53,Sirtuin","DNA Damage/DNA Repair","Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.",327.44,"1011301-27-1",{"v":65,"d":"65.00"},198.51,"<1","N/A","http://www.selleckchem.com/products/tenovin-3.html","C18H21N3OS","free base","N/A","CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(N)C=C2",{"v":4.42,"d":"4.420"},1,3,5]
["S3205","Perillaldehyde","g3","L9900-07","in 10mM DMSO","AhR,CCR,Nrf2,ROS","Metabolism","Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.",150.22,"18031-40-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/perillaldehyde.html","C10H14O","free base","Perilladehyde, Perillal, PAE, PA","CC(=C)C1CCC(=CC1)C=O",2.668,1,0,2]
["S3222","Raspberry ketone glucoside","h3","L9900-07","in 10mM DMSO","ROS","Immunology & Inflammation","Raspberry ketone glucoside (RKG), a natural product in raspberry fruit,  is an antioxidant that has the inhibitory effect on the melanin synthesis.",326.34,"38963-94-9",{"v":100,"d":"100.00"},306.43,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/raspberry-ketone-glucoside.html","C16H22O7","free base","RKG","CC(=O)CCC1=CC=C(OC2OC(CO)C(O)C(O)C2O)C=C1",-0.121,3,4,6]
["S3224","Cinobufagin","a4","L9900-07","in 10mM DMSO","Akt,Apoptosis related,ATM/ATR,Bcl-2,Caspase,CDK,Chk,PI3K","Cell Cycle","Cinobufagin (Cinobufagine), an active ingredient of Venenum Bufonis, inhibits tumor development. Cinobufagin increases ATM and Chk2 and decreases CDC25C, CDK1, and cyclin B. Cinobufagin inhibits PI3K, AKT  and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus, Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.",442.54,"470-37-1",{"v":100,"d":"100.00"},225.97,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/cinobufagin.html","C26H34O6","free base","Cinobufagine","CC(=O)OC1C2OC23C4CCC5CC(O)CCC5(C)C4CCC3(C)C1C6=COC(=O)C=C6",2.593,5,1,3]
["S3227","5,7-Dimethoxyflavone","b4","L9900-07","in 10mM DMSO","BCRP,P450 (e.g. CYP17)","Metabolism","5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.",282.29,"21392-57-4",{"v":100,"d":"100.00"},354.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/5-7-dimethoxyflavone.html","C17H14O4","free base","5,7-DMF","COC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)OC",3.103,4,0,3]
["S3238","Resibufogenin","c4","L9900-07","in 10mM DMSO","Akt,Apoptosis related,Bcl-2,Caspase,CDK,GSK-3,Mixed Lineage Kinase,PI3K,RIP kinase,ROS,Wnt/beta-catenin","Apoptosis","Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.",384.51,"465-39-4",{"v":100,"d":"100.00"},260.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/resibufogenin.html","C24H32O4","free base","Bufogenin, Recibufogenin","CC12CCC(O)CC1CCC3C2CCC4(C)C(CC5OC345)C6=COC(=O)C=C6",3.113,3,1,1]
["S3245","Nodakenetin","d4","L9900-07","in 10mM DMSO","AChR,Aldose Reductase,Apoptosis related,BACE,BChE,Bcl-2,Carbohydrate Metabolism,phosphatase","Metabolism","Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.",246.26,"495-32-9",{"v":100,"d":"100.00"},406.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/nodakenetin.html","C14H14O4","free base","NANI","CC(C)(O)C1CC2=C(O1)C=C3OC(=O)C=CC3=C2",2.029,3,0,1]
["S3264","Atractyloside potassium salt","e4","L9900-07","in 10mM DMSO","Chloride Channel,Mitochondrial Metabolism","Transmembrane Transporters","Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart.",802.99,"102130-43-8",{"v":100,"d":"100.00"},124.53,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/atractyloside-potassium-salt.html","C30H44K2O16S2","potassium","ATR potassium salt","[K+].[K+].CC(C)CC(=O)OC1C(OC2CC(C3CCC45CC(CCC4C3(C)C2)C(=C)C5O)C(O)=O)OC(CO)C(O[S]([O-])(=O)=O)C1O[S]([O-])(=O)=O",-2.748,7,2,12]
["S3267","Kaempferol-3-O-rutinoside","f4","L9900-07","in 10mM DMSO","Apoptosis related,Bcl-2,Caspase,JAK,STAT","JAK/STAT","Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.",594.52,"17650-84-9",{"v":100,"d":"100.00"},{"v":168.2,"d":"168.20"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/kaempferol-3-o-rutinoside.html","C27H30O15","free base","Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC=C(O)C=C5)C(O)C(O)C2O)C(O)C(O)C1O",-0.916,6,9,6]
["S3273","Hypericin","g4","L9900-07","in 10mM DMSO","Hydroxylase,MAO,P450 (e.g. CYP17),PKC,Reverse Transcriptase,Telomerase","Metabolism","Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).",504.44,"548-04-9",{"v":100,"d":"100.00"},198.24,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/hypericin.html","C30H16O8","free base","Hyp, HY","CC1=C2C3=C(C)C=C(O)C4=C3C5=C6C2=C(C(=C1)O)C(=O)C7=C6C(=C(O)C=C7O)C8=C(O)C=C(O)C(=C58)C4=O",{"v":5.04,"d":"5.040"},2,6,0]
["S3275","Senkyunolide I","h4","L9900-07","in 10mM DMSO","Apoptosis related,Bcl-2,Caspase,ERK,Nrf2","MAPK","Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic,  anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.",224.25,"94596-28-8",{"v":100,"d":"100.00"},445.93,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/senkyunolide-i.html","C12H16O4","free base","SEI, SENI","CCC\\C=C1/OC(=O)C2=C1CCC(O)C2O",1.316,2,2,2]
["S3291","Myristicin","a5","L9900-07","in 10mM DMSO","MAO,P450 (e.g. CYP17)","Metabolism","Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.",192.21,"607-91-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/myristicin.html","C11H12O3","free base","Myristicine","COC1=C2OCOC2=CC(=C1)CC=C",2.589,3,0,3]
["S3301","Cynarin","b5","L9900-07","in 10mM DMSO","CD markers,Glutathione,Nrf2,ROS","Immunology & Inflammation","Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.",516.45,"30964-13-7",{"v":100,"d":"100.00"},193.63,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/cynarin.html","C25H24O12","free base","Cynarine","OC1CC(CC(OC(=O)/C=C/C2=CC=C(O)C(=C2)O)C1O)(OC(=O)\\C=C\\C3=CC=C(O)C(=C3)O)C(O)=O",1.687,5,6,9]
["S6851","RA-190","c5","L9900-07","in 10mM DMSO","Autophagy,p53,Proteasome","Ubiquitin","RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.",596.76,"1617495-03-0",{"v":100,"d":"100.00"},167.57,"<1","N/A","http://www.selleckchem.com/products/ra-190.html","C28H23Cl5N2O2","free base","N/A","Cl.NC(CC1=CC=CC=C1)C(=O)N2CC(=C/C3=CC(=C(Cl)C=C3)Cl)/C(=O)C(/C2)=C\\C4=CC(=C(Cl)C=C4)Cl",7.285,2,1,5]
["S6852","Gossypol","d5","L9900-07","in 10mM DMSO","Apoptosis related,Bcl-2,Dehydrogenase","Apoptosis","Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.",518.55,"303-45-7",{"v":100,"d":"100.00"},192.85,"<1","N/A","http://www.selleckchem.com/products/gossypol.html","C30H30O8","free base","BL 193","CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(O)C4=C(C=C3C)C(=C(O)C(=C4C=O)O)C(C)C)O",6.592,2,6,5]
["S6882","HI-TOPK-032","e5","L9900-07","in 10mM DMSO","Apoptosis related,Caspase,ERK,p53,PARP,TOPK","MAPK","HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.",{"v":369.4,"d":"369.40"},"487020-03-1",{"v":4,"d":"4.00"},10.83,"<1","N/A","http://www.selleckchem.com/products/hi-topk-032.html","C20H11N5OS","free base","N/A","O=C(NC1=CC2=C(C#N)C3=C(N=C4C=CC=CC4=N3)[N]2C=C1)C5=CC=CS5",3.567,3,1,2]
["S6886","1-Aminobenzotriazole","f5","L9900-07","in 10mM DMSO","Histone Acetyltransferase,P450 (e.g. CYP17),Transferase","Metabolism","1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).",134.14,"1614-12-6",{"v":27,"d":"27.00"},201.28,{"v":27,"d":"27.00"},201.28,"http://www.selleckchem.com/products/1-aminobenzotriazole.html","C6H6N4","free base","ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987","N[N]1N=NC2=CC=CC=C12",0.943,2,1,0]
["S8590","GSK 2837808A","g5","L9900-07","in 10mM DMSO","Dehydrogenase,LDH","Metabolism","GSK2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.",649.62,"1445879-21-9",{"v":100,"d":"100.00"},153.94,"<1","N/A","http://www.selleckchem.com/products/gsk-2837808A.html","C31H25F2N5O7S","free base","N/A","COC1=NC=C(C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(O)=O)OC5=CC(=CC(=C5)F)F)[S](=O)(=O)NC6CC6)C(=N1)OC",5.335,9,2,11]
["S8974","GSK2795039","h5","L9900-07","in 10mM DMSO","Apoptosis related,NADPH-oxidase,ROS","Immunology & Inflammation","GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.",450.56,"1415925-18-6",{"v":90,"d":"90.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/gsk2795039.html","C23H26N6O2S","free base","N/A","CC(C)[N]1C=C(C2=CC=C3CCN(C)C3=C2)C4=C1N=CC=C4N[S](=O)(=O)C5=N[N](C)C=C5",3.536,4,1,5]
["S8978","Mitoquinone (MitoQ10) mesylate","a6","L9900-07","in 10mM DMSO","ROS","Immunology & Inflammation","Mitoquinone mesylate (MitoQ, MitoQ10, Mitoubiquinone) is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.",678.81,"845959-50-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/mitoquinone-mesylate.html","C38H47O7PS","mesylate","MitoQ, Mitoubiquinone","COC1=C(OC)C(=O)C(=C(C)C1=O)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.C[S]([O-])(=O)=O",6.675,4,0,16]
["S9604","IM156","b6","L9900-07","in 10mM DMSO","AMPK,Apoptosis related,OXPHOS","PI3K/Akt/mTOR","IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156 ameliorates various types of fibrosis and inhibits tumors.",315.29,"1422365-93-2",{"v":63,"d":"63.00"},199.82,"<1","N/A","http://www.selleckchem.com/products/im156.html","C13H16F3N5O","free base","HL156A","FC(F)(F)OC1=CC=C(NC(=N)NC(=N)N2CCCC2)C=C1",3.622,1,2,7]
["S9611","ABTL-0812","c6","L9900-07","in 10mM DMSO","Akt,Autophagy,mTOR,ROS","PI3K/Akt/mTOR","ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.",296.44,"57818-44-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/abtl-0812.html","C18H32O3","free base","α-Hydroxylinoleic acid","CCCCC\\C=C/C\\C=C/CCCCCCC(O)C(O)=O",5.629,1,1,14]
["S9687","H2DCFDA","d6","L9900-07","in 10mM DMSO","ROS","Immunology & Inflammation","H2DCFDA (DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) production.",487.29,"4091-99-0",{"v":97,"d":"97.00"},199.06,{"v":97,"d":"97.00"},199.06,"http://www.selleckchem.com/products/h2dcfda.html","C24H16Cl2O7","free base","DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate","CC(=O)OC1=CC2=C(C=C1Cl)C(C3=C(O2)C=C(OC(C)=O)C(=C3)Cl)C4=C(C=CC=C4)C(O)=O",5.312,6,0,6]
["S0056","(E/Z)-BCI","e6","L9900-07","in 10mM DMSO","Apoptosis related,phosphatase,ROS","Metabolism","(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.",317.42,"15982-84-0",{"v":63,"d":"63.00"},198.48,"<1","N/A","https://www.selleckchem.com/products/dual-specificity-protein-phosphatase-1-6-Inhibitor-bcl.html","C22H23NO","Free Base","BCI, NSC 150117","O=C1\\C(=C/C2=CC=CC=C2)C(NC3CCCCC3)C4=CC=CC=C14",{"v":4.84,"d":"4.840"},1,1,3]
["S0110","APD597","f6","L9900-07","in 10mM DMSO","GPR,P450 (e.g. CYP17)","GPCR & G Protein","APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. APD-597 (JNJ-38431055) is developed for treating Type 2 diabetes (T2D).",479.55,"897732-93-3",{"v":96,"d":"96.00"},200.19,"<1","N/A","https://www.selleckchem.com/products/apd597.html","C21H29N5O6S","Free Base","JNJ-38431055","COC1=C(NC2=C(C)N=C(C=C2)[S](C)(=O)=O)N=CN=C1OC3CCN(CC3)C(=O)OC(C)C",2.583,9,1,8]
["S0166","BRITE338733","g6","L9900-07","in 10mM DMSO","ATPase","Transmembrane Transporters","BRITE-338733 is a potent RecA (a DNA-dependent ATPase) inhibitor with IC50 of 4.7 µM.",433.59,"503105-88-2",{"v":87,"d":"87.00"},200.65,"<1","N/A","https://www.selleckchem.com/products/brite338733.html","C27H35N3O2","Free Base","N/A","CCC1=CC=C(O1)C2=CC(=NC(=C2)NC3CC(C)(C)NC(C)(C)C3)C4=C(O)C=CC(=C4)C",5.684,2,3,5]
["S0274","2-DI-1-ASP","h6","L9900-07","in 10mM DMSO","Dyes","Others","2-Di-1-ASP (DASPI, 2M2PM, D 308, Compound 18a) is a mono-stryryl dye which can be used as a mitochondrial stain and a groove-binding fluorescent probe for G-quadruplex (G4) DNA.",366.24,"2156-29-8",{"v":30,"d":"30.00"},81.91,"<1","N/A","https://www.selleckchem.com/products/2-di-1-asp.html","C16H19IN2","Free Base","DASPI, 2M2PM, D 308","[I-].CN(C)C1=CC=C(C=C1)\\C=C\\C2=CC=CC=[N+]2C",0.762,0,0,3]
["S0283","COH-29","a7","L9900-07","in 10mM DMSO","RNR","DNA Damage/DNA Repair","COH29 (RNR Inhibitor COH29) is a potent inhibitor of ribonucleotide reductase (RNR) with anticancer activity. COH29 (RNR Inhibitor COH29) inhibits recombinant RNR small subunit (RRM1/RRM2) activity in vitro with IC50 of 16 μM.",420.44,"1190932-38-7",{"v":40,"d":"40.00"},95.14,{"v":60,"d":"60.00"},142.71,"https://www.selleckchem.com/products/coh-29.html","C22H16N2O5S","Free Base","RNR Inhibitor COH29","OC1=C(O)C=C(C=C1)C(=O)NC2=NC(=C(S2)C3=CC=CC=C3)C4=CC(=C(O)C=C4)O",{"v":4.4,"d":"4.400"},2,5,4]
["S0354","Alsterpaullone","b7","L9900-07","in 10mM DMSO","Apoptosis related,Caspase,CDK,GSK-3","Cell Cycle","Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.",293.28,"237430-03-4",{"v":25,"d":"25.00"},85.24,"<1","N/A","https://www.selleckchem.com/products/alsterpaullone.html","C16H11N3O3","Free Base","Alp, 9-Nitropaullone, NSC 705701","[O-][N+](=O)C1=CC2=C([NH]C3=C2CC(=O)NC4=CC=CC=C34)C=C1",2.817,1,2,1]
["S0411","BAM 15","c7","L9900-07","in 10mM DMSO","AMPK,Apoptosis related,Mitochondrial Metabolism","PI3K/Akt/mTOR","BAM 15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. BAM 15 is also a potent AMPK activator. BAM 15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.",340.29,"210302-17-3",{"v":68,"d":"68.00"},199.83,"<1","N/A","https://www.selleckchem.com/products/bam-15.html","C16H10F2N6O","Free Base","N/A","FC1=CC=CC=C1NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F",4.079,5,2,4]
["S0454","Adjudin","d7","L9900-07","in 10mM DMSO","Chloride Channel,ERK,NF-κB","Transmembrane Transporters","Adjudin (AF-2364), a potent male contraceptive, is a potent blocker of Cl⁻ channels. Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.",335.19,"252025-52-8",{"v":67,"d":"67.00"},199.89,"<1","N/A","https://www.selleckchem.com/products/adjudin.html","C15H12Cl2N4O","Free Base","AF-2364","NNC(=O)C1=N[N](CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C13",{"v":3.53,"d":"3.530"},2,2,3]
["S0856","KM91104","e7","L9900-07","in 10mM DMSO","ATPase","Transmembrane Transporters","KM 91104 is a cell-permeable inhibitor of V-ATPase that specifically targets the interaction between V-ATPase subunit a3 and subunit B2.",272.26,"304481-60-5",{"v":54,"d":"54.00"},198.34,"<1","N/A","https://www.selleckchem.com/products/km91104.html","C14H12N2O4","Free Base","N/A","OC1=C(O)C=C(C=C1)C(=O)NN=CC2=CC=CC=C2O",1.957,2,4,3]
["S0881","Mitochonic acid 5","f7","L9900-07","in 10mM DMSO","ERK,Mitophagy,YAP","Autophagy","Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Mitochonic acid 5 modulates mitochondrial ATP synthesis.",{"v":329.3,"d":"329.30"},"1354707-41-7",{"v":25,"d":"25.00"},75.92,"<1","N/A","https://www.selleckchem.com/products/mitochonic-acid-5.html","C18H13F2NO3","Free Base","MA-5","OC(=O)C(CC(=O)C1=C(F)C=C(F)C=C1)C2=C[NH]C3=CC=CC=C23",3.614,2,1,5]
["S0913","4',5,7-Trimethoxyflavone","g7","L9900-07","in 10mM DMSO","Apoptosis related,Caspase,PARP","Apoptosis","4',5,7-Trimethoxyflavone (5,​7,​4'-​Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.",312.32,"5631-70-9",{"v":62,"d":"62.00"},198.51,"<1","N/A","https://www.selleckchem.com/products/4-5-7-trimethoxyflavone.html","C18H16O5","Free Base","5,​7,​4'-​Trimethoxyflavone, TMF","COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(OC)C=C3OC",3.087,5,0,4]
["S0977","AC1903","h7","L9900-07","in 10mM DMSO","TRP Channel","Transmembrane Transporters","AC1903 (compound 2) is a specific and selective TRPC5 (transient receptor potential canonical channel 5) inhibitor with IC50 of 4.06 μM.",303.36,"831234-13-0",{"v":60,"d":"60.00"},197.78,"<1","N/A","https://www.selleckchem.com/products/ac1903.html","C19H17N3O","Free Base","N/A","C(NC1=NC2=CC=CC=C2[N]1CC3=CC=CC=C3)C4=CC=CO4",{"v":4.25,"d":"4.250"},2,1,5]
["S0983","JX06","a8","L9900-07","in 10mM DMSO","PDK","PI3K/Akt/mTOR","JX06 is a selective covalent inhibitor of PDK1 in cells. JX06 dose-dependently inhibits PDK1, PDK2 and PDK3 with IC50 0.049 μM, 0.101 μM and 0.313 μM, respectively.",324.51,"729-46-4",{"v":65,"d":"65.00"},{"v":200.3,"d":"200.30"},"<1","N/A","https://www.selleckchem.com/products/jx06.html","C10H16N2O2S4","Free Base","N/A","S=C(SSC(=S)N1CCOCC1)N2CCOCC2",{"v":3.58,"d":"3.580"},2,0,5]
["S2798","GW6471","b8","L9900-07","in 10mM DMSO","PPAR","Metabolism","GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM.",619.67,"880635-03-0 (436159-64-7 deprecated)",{"v":100,"d":"100.00"},161.38,"<1","N/A","https://www.selleckchem.com/products/gw6471.html","C35H36F3N3O4","Free Base","N/A","CCC(=O)NCC(CC1=CC=C(OCCC2=C(C)OC(=N2)C3=CC=CC=C3)C=C1)N\\C(C)=C/C(=O)C4=CC=C(C=C4)C(F)(F)F",6.435,5,2,15]
["S2987","4-Methyl-2-oxovaleric acid","c8","L9900-07","in 10mM DMSO","Dehydrogenase,OXPHOS","Apoptosis","4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) is released by Astrocytes to neurons and can be reaminated by aminotransferase to leucine. 4-Methyl-2-oxovaleric acid reduces the rate of protein degradation in skeletal muscle. 4-Methyl-2-oxovaleric acid acts as an uncoupler of oxidative phosphorylation (OXPHOS) and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) activity.",130.14,"816-66-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/4-methyl-2-oxovaleric-acid.html","C6H10O3","Free Base","Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate","CC(C)CC(=O)C(O)=O",1.046,2,0,3]
["S3143","Pyruvic acid","d8","L9900-07","in 10mM DMSO","ATPase,Casein Kinase,LDH","Metabolism","Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca2+Mg2+-ATPase and Na+K+-ATPase.",88.06,"127-17-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/pyruvic-acid.html","C3H4O3","Free Base","Acetylformic acid","CC(=O)C(O)=O",-0.329,2,0,1]
["S6920","SEA0400","e8","L9900-07","in 10mM DMSO","Calcium Channel,ERK,NCX,p38 MAPK,ROS,Sodium Channel","Transmembrane Transporters","SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.",371.38,"223104-29-8",{"v":74,"d":"74.00"},199.26,"<1","N/A","https://www.selleckchem.com/products/sea0400.html","C21H19F2NO3","Free Base","N/A","CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(=C3)F)C=C2)C(=C1)N",4.954,3,1,7]
["S6959","Perhexiline maleate","f8","L9900-07","in 10mM DMSO","CPT","Metabolism","Perhexiline maleate is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT1) with IC50s of 77 μM and 148 μM for rat heart CPT1 and liver CPT1, respectively, and also inhibits carnitine palmitoyltransferase 2 (CPT2).",393.56,"6724-53-4",{"v":78,"d":"78.00"},198.19,"<1","N/A","https://www.selleckchem.com/products/perhexiline-maleate.html","C23H39NO4","Maleate","N/A","OC(=O)\\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3",3.054,2,1,6]
["S6962","TPEN","g8","L9900-07","in 10mM DMSO","Apoptosis related,NOS","Apoptosis","TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling. TPEN (TPEDA) may be a potential therapeutic strategy for APL (acute promyelocytic leukemia).",424.54,"16858-02-9",{"v":85,"d":"85.00"},200.22,"<1","N/A","https://www.selleckchem.com/products/tpen.html","C26H28N6","Free Base","TPEDA","C(CN(CC1=NC=CC=C1)CC2=NC=CC=C2)N(CC3=NC=CC=C3)CC4=NC=CC=C4",{"v":3.05,"d":"3.050"},4,0,11]
["S9161","Ziyuglycoside II","h8","L9900-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties.",604.81,"35286-59-0",{"v":100,"d":"100.00"},165.34,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/ziyuglycoside-ii.html","C35H56O8","Free Base","N/A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC34C)C2C1(C)O)C(O)=O",4.107,3,3,3]
["S9187","Phillygenin","a9","L9900-07","in 10mM DMSO","LDL","Metabolism","Phillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein.",372.41,"487-39-8",{"v":74,"d":"74.00"},198.71,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/phillygenin.html","C21H24O6","Free Base","Sylvatesmin","COC1=C(OC)C=C(C=C1)C2OCC3C2COC3C4=CC(=C(O)C=C4)OC",2.409,5,1,5]
["S9210","Ginsenoside Rk1","b9","L9900-07","in 10mM DMSO","Others","Others","Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity.",{"v":767,"d":"767.00"},"494753-69-4",{"v":100,"d":"100.00"},130.38,{"v":100,"d":"100.00"},130.38,"https://www.selleckchem.com/products/ginsenoside-rk1.html","C42H70O12","Free Base","N/A","CC(C)=CCCC(=C)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",3.315,4,8,10]
["S9262","Raddeanin A","c9","L9900-07","in 10mM DMSO","HDAC","Epigenetics","Raddeanin A (Raddeanin R3, NSC382873), a triterpenoid saponin from Anemone raddeana Regel, displays moderate inhibitory activity against histone deacetylases (HDACs) and has high antiangiogenic potency, antitumor activity.",{"v":897.1,"d":"897.10"},"89412-79-3",{"v":100,"d":"100.00"},111.47,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/raddeanin-a.html","C47H76O16","Free Base","Raddeanin R3, NSC382873","CC1OC(OC2C(O)C(O)C(CO)OC2OC3C(O)C(O)COC3OC4CCC5(C)C(CCC6(C)C5CC=C7C8CC(C)(C)CCC8(CCC67C)C(O)=O)C4(C)C)C(O)C(O)C1O",2.605,7,8,8]
["S9617","G6PDi-1","d9","L9900-07","in 10mM DMSO","Dehydrogenase,NADPH-oxidase","Metabolism","G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.",284.34,"2457232-14-1",{"v":57,"d":"57.00"},200.46,"<1","N/A","https://www.selleckchem.com/products/g6pdi-1.html","C14H12N4OS","Free Base","N/A","O=C1CCCCC2=C1C=NC(=N2)NC3=CSC(=C3)C#N",2.939,3,1,2]
["S9645","CBR-5884","e9","L9900-07","in 10mM DMSO","Dehydrogenase","Metabolism","CBR-5884 is a selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and was selectively toxic to cancer cell lines with high serine biosynthetic activity.",336.39,"681159-27-3",{"v":67,"d":"67.00"},199.17,"<1","N/A","https://www.selleckchem.com/products/cbr-5884.html","C14H12N2O4S2","Free Base","N/A","CCOC(=O)C1=C(C)C(=C(NC(=O)C2=CC=CO2)S1)SC#N",3.252,4,1,6]
["S9682","FICZ","f9","L9900-07","in 10mM DMSO","AhR","Metabolism","FICZ (6-Formylindolo[3,2-b]carbazole) is a potent agonist of aryl hydrocarbon receptor (AhR) that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes.",284.31,"172922-91-7",{"v":57,"d":"57.00"},200.49,"<1","N/A","https://www.selleckchem.com/products/ficz.html","C19H12N2O","Free Base","6-Formylindolo[3,2-b]carbazole","O=CC1=C2C(=CC3=C1[NH]C4=C3C=CC=C4)[NH]C5=C2C=CC=C5",4.576,1,2,1]
["S9743","Ciliobrevin D","g9","L9900-07","in 10mM DMSO","Hedgehog/Smoothened","GPCR & G Protein","Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor cytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocks Hedgehog (Hh) signaling.",392.62,"1370554-01-0",{"v":20,"d":"20.00"},50.94,"<1","N/A","https://www.selleckchem.com/products/ciliobrevin-d.html","C17H8Cl3N3O2","Free Base","N/A","ClC1=CC(=C(C=C1)C(=O)C(\\C#N)=C2/NC(=O)C3=CC=C(Cl)C=C3N2)Cl",4.511,2,2,2]
["S0161","ML367","h9","L9900-07","in 10mM DMSO","ATPase,DNA/RNA Synthesis","Transmembrane Transporters","ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. ML367 blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.",334.32,"381168-77-0",{"v":67,"d":"67.00"},200.41,"<1","N/A","http://www.selleckchem.com/products/ml367.html","C19H12F2N4","Free Base","N/A","FC1=C(F)C=C(NC2=NC(=NC3=CC=CC=C23)C4=CC=NC=C4)C=C1",4.357,3,1,3]
["S0522","CM10","a10","L9900-07","in 10mM DMSO","Dehydrogenase","Metabolism","CM10 is a potent and selective inhibitor of aldehyde dehydrogenase 1A family (ALDH1A) with IC50 of 1700 nM, 740 nM and 640 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively. CM10 exhibits anti-cancer activity.",321.42,"692269-09-3",{"v":64,"d":"64.00"},199.12,"<1","N/A","http://www.selleckchem.com/products/cm10.html","C20H23N3O","Free Base","N/A","CCC[N]1C(=NC2=CC=CC=C12)NCC3=CC=CC(=C3O)CC=C",5.123,1,2,7]
["S0764","AKR1C1-IN-1","b10","L9900-07","in 10mM DMSO","AKR1C,Dehydrogenase","Immunology & Inflammation","AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively.",293.11,"4906-68-7",{"v":59,"d":"59.00"},201.29,"<1","N/A","http://www.selleckchem.com/products/akr1c1-in-1.html","C13H9BrO3","Free Base","N/A","OC(=O)C1=C(O)C(=CC(=C1)C2=CC=CC=C2)Br",3.484,1,1,2]
["S2968","CTPI-2","c10","L9900-07","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs).",356.74,"68003-38-3",{"v":71,"d":"71.00"},199.02,"<1","N/A","http://www.selleckchem.com/products/ctpi-2.html","C13H9ClN2O6S","Free Base","N/A","OC(=O)C1=CC=CC=C1N[S](=O)(=O)C2=CC(=C(Cl)C=C2)[N+]([O-])=O",2.506,3,1,5]
["S3375","Mitochondrial Fusion Promoter M1","d10","L9900-07","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury.",364.05,"219315-22-7",{"v":73,"d":"73.00"},200.52,"<1","N/A","http://www.selleckchem.com/products/mitochondrial-fusion-promoter-m1.html","C14H10Cl4N2O","Free Base","N/A","CC(=N/NC1=C(Cl)C=C(Cl)C=C1Cl)\\C2=C(O)C=CC(=C2)Cl",5.844,1,2,3]
["S3449","GSK5182","e10","L9900-07","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","GSK5182, 4-hydroxytamoxifen analog, is a specific inverse agonist of estrogen-related receptor γ (ERRγ) that inhibits pro-inflammatory cytokine-induced catabolic factors.",417.54,"877387-37-6",{"v":84,"d":"84.00"},201.18,"<1","N/A","http://www.selleckchem.com/products/gsk5182.html","C27H31NO3","Free Base","N/A","CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCO)C2=CC=CC=C2)C3=CC=C(O)C=C3",5.308,1,2,10]
["S3565","Brequinar Sodium","f10","L9900-07","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.",397.35,"96201-88-6",{"v":79,"d":"79.00"},198.82,{"v":26,"d":"26.00"},65.43,"http://www.selleckchem.com/products/bipenquinate.html","C23H14F2NNaO2","Sodium","Bipenquinate, BRQ, DUP-785, NSC 368390","CC1=C(C(=O)O[Na])C2=CC(=CC=C2N=C1C3=CC=C(C=C3)C4=C(F)C=CC=C4)F",6.099,3,0,4]
["S3577","Rhodamine 123","g10","L9900-07","in 10mM DMSO","ATPase,Dyes","Transmembrane Transporters","Rhodamine 123 (RH-123, R-22420) is a fluorescent cationic dye used to label mitochondria in living cells. Rhodamine 123 inhibits ADP-stimulated respiration of mitochondria with Ki = 12 μM and ATPase activity of inverted inner membrane vesicles with Ki of 126 μM and partially purified F1-ATPase with Ki of 177 μM.",380.82,"62669-70-9",{"v":76,"d":"76.00"},199.57,"<1","N/A","http://www.selleckchem.com/products/rhodamine-123.html","C21H17ClN2O3","Free Base","RH-123, R-22420","Cl.COC(=O)C1=CC=CC=C1C2=C3C=CC(=N)C=C3OC4=C2C=CC(=C4)N",3.216,3,1,3]
["S3593","Rhodamine 6G","h10","L9900-07","in 10mM DMSO","Dyes,Mitochondrial Metabolism","Metabolism","Rhodamine 6G (R6G, Basic Red 1, Rhodamine 590) is a fluorescence tracer that binds to mitochondria, thus reducing the intact mitochondria number and inhibiting mitochondrial metabolic activity.",479.01,"989-38-8",{"v":96,"d":"96.00"},200.41,"<1","N/A","http://www.selleckchem.com/products/rhodamine-6g.html","C28H31ClN2O3","Free Base","R6G, Basic Red 1, Rhodamine 590","[Cl-].CCNC1=CC2=C(C=C1C)C(=C3C=C(C)C(C=C3O2)=[NH+]CC)C4=CC=CC=C4C(=O)OCC",2.797,3,1,7]
["S4419","Ensulizole","a11","L9900-07","in 10mM DMSO","ROS","Immunology & Inflammation","Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation.",{"v":274.3,"d":"274.30"},"27503-81-7",{"v":5,"d":"5.00"},18.23,"<1","N/A","http://www.selleckchem.com/products/ensulizole.html","C13H10N2O3S","Free Base","PBSA","O[S](=O)(=O)C1=CC2=C(C=C1)N=C([NH]2)C3=CC=CC=C3",2.603,1,1,2]
["S4425","Rifamycin S","b11","L9900-07","in 10mM DMSO","Antibiotics,Bacterial,ROS","Immunology & Inflammation","Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.",695.75,"13553-79-2",{"v":100,"d":"100.00"},143.73,"<1","N/A","http://www.selleckchem.com/products/rifamycin-s.html","C37H45NO12","Free Base","N/A","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=O)C(=CC4=O)NC(=O)\\C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C",2.779,9,4,3]
["S4483","Iproniazid phosphate","c11","L9900-07","in 10mM DMSO","MAO","Neuronal Signaling","Iproniazid (Marsilid, Iprazid) phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.",277.21,"305-33-9",{"v":55,"d":"55.00"},198.41,{"v":55,"d":"55.00"},198.41,"http://www.selleckchem.com/products/iproniazid-phosphate.html","C9H16N3O5P","Phosphate","N/A","CC(C)NNC(=O)C1=CC=NC=C1.O[P](O)(O)=O",-0.347,2,2,3]
["S4489","Tetraethylammonium chloride","d11","L9900-07","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Tetraethylammonium (TEA) chloride is a nonspecific potassium channel blocker with antitumor properties.",{"v":165.7,"d":"165.70"},"56-34-8",{"v":33,"d":"33.00"},199.16,{"v":33,"d":"33.00"},199.16,"http://www.selleckchem.com/products/tetraethylammonium-chloride.html","C8H20ClN","Free Base","TEA chloride","[Cl-].CC[N+](CC)(CC)CC",-2.314,0,0,4]
["S4531","Iohexol","e11","L9900-07","in 10mM DMSO","Others","Others","Iohexol (Omnipaque) is a radiographic contrast agent that can be used as an exogenous filtration marker for accurate glomerular filtration rate (GFR) estimates.",821.14,"66108-95-0",{"v":100,"d":"100.00"},121.78,{"v":100,"d":"100.00"},121.78,"http://www.selleckchem.com/products/iohexol.html","C19H26I3N3O9","Free Base","Omnipaque","CC(=O)N(CC(O)CO)C1=C(I)C(=C(I)C(=C1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO",-1.844,3,8,12]
["S4929","Enasidenib Mesylate","f11","L9900-07","in 10mM DMSO","Dehydrogenase","Metabolism","Enasidenib (Idhifa, AG-221) mesylate is an orally available, selective and potent inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).",569.48,"1650550-25-6",{"v":100,"d":"100.00"},{"v":175.6,"d":"175.60"},"<1","N/A","http://www.selleckchem.com/products/enasidenib-mesylate.html","C20H21F6N7O4S","Mesylate","Idhifa, AG-221 mesylate","CC(C)(O)CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F.C[S](O)(=O)=O",4.464,5,2,8]
["S5190","Crizotinib hydrochloride","g11","L9900-07","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",{"v":486.8,"d":"486.80"},"1415560-69-8",{"v":97,"d":"97.00"},199.26,{"v":97,"d":"97.00"},199.26,"http://www.selleckchem.com/products/crizotinib-hydrochloride.html","C21H23Cl3FN5O","Hydrochloride","Xalkori, PF-02341066 hydrochloride","Cl.CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",4.075,3,2,5]
["S5608","Pantoprazole sodium hydrate","h11","L9900-07","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) is a potent inhibitor of H+/K(+)-ATPase with IC50 of 6.8 μM.",864.75,"164579-32-2",{"v":100,"d":"100.00"},115.64,{"v":17,"d":"17.00"},19.66,"http://www.selleckchem.com/products/pantoprazole-sodium-hydrate.html","C32H34F4N6Na2O11S2","Sodium hydrate","Protonix, BY1023 sodium hydrate, SKF96022 sodium hydrate","O.O.O.[Na+].[Na+].COC1=C(OC)C(=NC=C1)C[S](=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F.COC4=C(OC)C(=NC=C4)C[S](=O)C5=NC6=C([N-]5)C=CC(=C6)OC(F)F",5.145,12,0,14]
["S5922","L-Carnitine hydrochloride","a2","L9900-08","in 10mM DMSO","Leukotriene","Metabolism","L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride improves oxygen saturation, and inhibits leukotriene synthesis. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation.",197.66,"6645-46-1",{"v":40,"d":"40.00"},202.37,{"v":40,"d":"40.00"},202.37,"http://www.selleckchem.com/products/l-carnitine-hydrochloride.html","C7H16ClNO3","Hydrochloride","(R)-Carnitine hydrochloride, Levocarnitine hydrochloride","[Cl-].C[N+](C)(C)CC(O)CC(O)=O",{"v":-4.49,"d":"-4.490"},1,1,4]
["S5958","Metformin","b2","L9900-08","in 10mM DMSO","AMPK,Apoptosis related,JNK,Mitophagy,p38 MAPK","PI3K/Akt/mTOR","Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",129.16,"657-24-9",{"v":26,"d":"26.00"},{"v":201.3,"d":"201.30"},{"v":26,"d":"26.00"},{"v":201.3,"d":"201.30"},"http://www.selleckchem.com/products/metformin.html","C4H11N5","Free Base","1,1-Dimethylbiguanide","CN(C)C(=N)NC(N)=N",-0.742,0,2,3]
["S9721","Farudodstat","c2","L9900-08","in 10mM DMSO","AP-1,Apoptosis related,Dehydrogenase","Metabolism","Farudodstat(LAS 186323,ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.",356.32,"1035688-66-4",{"v":71,"d":"71.00"},199.26,"<1","N/A","http://www.selleckchem.com/products/aslan003.html","C19H14F2N2O3","Free Base","LAS 186323,ASLAN003","COC1=CC=CC(=C1)C2=CC(=C(NC3=NC=CC=C3C(O)=O)C(=C2)F)F",4.311,3,1,5]
["S9783","6-Aminonicotinamide","d2","L9900-08","in 10mM DMSO","Dehydrogenase","Metabolism","6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. 6-Aminonicotinamide is a competitive inhibitor of NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with Ki of 0.46 μM.",137.14,"329-89-5",{"v":27,"d":"27.00"},196.88,"<1","N/A","http://www.selleckchem.com/products/6-aminonicotinamide.html","C6H7N3O","Free Base","6AN","NC(=O)C1=CC=C(N)N=C1",-0.526,2,2,1]
["S0778","LC3-mHTT-IN-AN1","e2","L9900-08","in 10mM DMSO","LC3","Autophagy","LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.",411.04,"486443-73-6",{"v":82,"d":"82.00"},199.49,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/lc3-mhtt-in-an1.html","C15H9Br2NO3","Free Base","N/A","OC1=C(O)C(=CC(=C1)/C=C/2C(=O)NC3=C2C=C(Br)C=C3)Br",3.743,1,3,1]
["S6301","MPP+ iodide","f2","L9900-08","in 10mM DMSO","Autophagy,Dopamine Receptor,Serotonin Transporter","Autophagy","MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.",297.13,"36913-39-0",{"v":72,"d":"72.00"},242.32,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/mpp-iodide.html","C12H12IN","Iodide","N-Methyl-4-Phenylpyridinium Iodide","[I-].C[N+]1=CC=C(C=C1)C2=CC=CC=C2",{"v":-0.16,"d":"-0.160"},0,0,1]
["S6895","TCPOBOP","g2","L9900-08","in 10mM DMSO","Bcl-2,CAR","Metabolism","TCPOBOP is a constitutive androstane receptor (CAR) agonist. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.",402.06,"76150-91-9",{"v":10,"d":"10.00"},24.87,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/tcpobop.html","C16H8Cl4N2O2","Free Base","N/A","ClC1=CC(=C(OC2=CC=C(OC3=C(Cl)C=C(Cl)C=N3)C=C2)N=C1)Cl",6.385,4,0,4]
["S6909","Levomefolic acid","h2","L9900-08","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.",459.46,"31690-09-2",{"v":46,"d":"46.00"},100.12,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/levomefolic-acid.html","C20H25N7O6","Free Base","5-MTHF, LMSR, Metafolin, Nutrifolin","CN1C(CNC2=CC=C(C=C2)C(=O)NC(CCC(O)=O)C(O)=O)CNC3=C1C(=O)N=C(N)N3",-0.794,5,5,9]
["S6953","GW406108X","a3","L9900-08","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.",400.21,"1644443-92-4",{"v":80,"d":"80.00"},{"v":199.9,"d":"199.90"},"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/gw406108x.html","C20H11Cl2NO4","Free Base","GW108X","OC1=C(Cl)C=C(C=C1Cl)/C=C/2C(=O)NC3=C2C=C(C=C3)C(=O)C4=CC=CO4",4.617,3,2,3]
["S9729","Visomitin (SKQ1)","b3","L9900-08","in 10mM DMSO","Others","Others","Visomitin (SKQ1) is a novel mitochondrial-targeted antioxidant that holds promise in the treatment of inflammation associated with ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 shows a TC50 of 317 nM on HCjE cells.",{"v":617.6,"d":"617.60"},"934826-68-3","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/visomitin-skq1.html","C36H42BrO2P","Free Base","N/A","[Br-].CC1=C(C)C(=O)C(=CC1=O)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4",7.986,2,0,14]
["S9733","Mito-TEMPO","c3","L9900-08","in 10mM DMSO","RIP kinase","Apoptosis","Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.",510.03,"1334850-99-5",{"v":100,"d":"100.00"},196.07,{"v":100,"d":"100.00"},196.07,"http://www.selleckchem.com/products/mito-tempo.html","C29H35N2O2P.Cl","Free Base","N/A","[Cl-].CC1(C)CC(CC(C)(C)N1[O])NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4",2.297,1,1,6]
["S9776","AG-636","d3","L9900-08","in 10mM DMSO","Dehydrogenase","Metabolism","AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.",343.38,"1623416-31-8",{"v":35,"d":"35.00"},101.93,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ag-636.html","C21H17N3O2","Free Base","N/A","C[N]1N=NC2=CC(=CC(=C12)C(O)=O)C3=CC=C(C=C3)C4=CC=CC=C4C",4.793,3,0,3]
["S9842","MCU-i4","e3","L9900-08","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.",377.48,"371924-24-2",{"v":10,"d":"10.00"},26.49,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/mcu-i4.html","C23H27N3O2","Free Base","N/A","CCOC(=O)C1=C(NC2=CC=C(C=C2)N(CC)CC)C3=C(C=CC(=C3)C)N=C1",5.116,3,1,8]
["S9860","BC1618","f3","L9900-08","in 10mM DMSO","AMPK,Autophagy","PI3K/Akt/mTOR","BC1618 is an orally active Fbxo48 inhibitor that stimulates adenosine monophosphate (AMP)-activated protein kinase (Ampk)-dependent signaling. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.",415.45,"2222094-18-8",{"v":83,"d":"83.00"},199.78,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/bc1618.html","C24H24F3NO2","Free Base","N/A","OC(COC1=CC=C(C=C1)C(F)(F)F)CN(CC2=CC=CC=C2)CC3=CC=CC=C3",{"v":5.55,"d":"5.550"},1,1,10]
["S9885","MYLS22","g3","L9900-08","in 10mM DMSO","Others","Others","MYLS22  is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) with anti-angiogenesis and anti-cancer activity.",443.52,"306959-01-3",{"v":81,"d":"81.00"},182.63,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/myls22.html","C24H21N5O2S","Free Base","N/A","CN1N(C(=O)C(=C1C)NC(=O)C2=CC3=C(S2)[N](N=C3C)C4=CC=CC=C4)C5=CC=CC=C5",3.247,3,1,4]
["E0009","Harmane","h3","L9900-08","in 10mM DMSO","MAO","Neuronal Signaling","Harmane (Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439) is a common compound in several foods, plants and beverages. Harmane is a selective monoamine oxidase inhibitors with IC50s of 0.5 μM and 5 μM for human MAO A and MAO B, respectively. Harmane also inhibits the apurinic/apyrimidinic (AP) endonuclease activity of the UV endonuclease induced by phage T4.",182.22,"486-84-0",{"v":36,"d":"36.00"},197.56,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/harmane.html","C12H10N2","Free Base","Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439","CC1=NC=CC2=C1[NH]C3=CC=CC=C23",2.455,1,1,0]
["E0011","Linderalactone","a4","L9900-08","in 10mM DMSO","Bcl-2,JAK,STAT","Apoptosis","Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.",244.29,"728-61-0",{"v":49,"d":"49.00"},200.58,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/linderalactone.html","C15H16O3","Free Base","N/A","CC/1=C\\CCC2=CC(OC2=O)C3=C(C1)OC=C3C",3.391,3,0,0]
["E0025","2-Hydroxybenzylamine","b4","L9900-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","2-Hydroxybenzylamine (2-(Aminomethyl)phenol, 2-HOBA, NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress.",123.15,"932-30-9",{"v":25,"d":"25.00"},{"v":203,"d":"203.00"},{"v":4,"d":"4.00"},32.48,"http://www.selleckchem.com/products/2-hydroxybenzylamine.html","C7H9NO","Free Base","2-(Aminomethyl)phenol, 2-HOBA,  NSC 127870","NCC1=CC=CC=C1O",0.693,0,2,1]
["E0032","Olesoxime (TRO 19622)","c4","L9900-08","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","Olesoxime (TRO19622) is a novel, orally active and CNS-penetrant mitochondrial-targeted neuroprotective compound.",399.65,"22033-87-0",{"v":80,"d":"80.00"},200.18,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/olesoxime-tro-19622.html","C27H45NO","Free Base","N/A","CC(C)CCCC(C)C1CCC2C3CCC4=CC(/CCC4(C)C3CCC12C)=N/O",7.678,1,0,5]
["S0220","ML240","d4","L9900-08","in 10mM DMSO","p97","Ubiquitin","ML240 is an ATP-competitive inhibitor of p97 ATPase with an IC50 of 0.11 μM and a Ki of 0.22 μM.",396.44,"1346527-98-7",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://www.selleckchem.com/products/ml240.html","C23H20N6O","Free Base","N/A","COC1=CC=CC2=C1N=C(N=C2NCC3=CC=CC=C3)[N]4C(=NC5=CC=CC=C45)N",{"v":4.92,"d":"4.920"},4,2,5]
["S6386","MRT67307","e4","L9900-08","in 10mM DMSO","IκB/IKK,TBK1,ULK","Immunology & Inflammation","MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells.",{"v":464.6,"d":"464.60"},"1190378-57-4",{"v":92,"d":"92.00"},198.02,"<1","N/A","http://www.selleckchem.com/products/mrt67307.html","C26H36N6O2","Free Base","IKKε/TBK1 Inhibitor II","O=C(NCCCNC1=NC(=NC=C1C2CC2)NC3=CC=CC(=C3)CN4CCOCC4)C5CCC5",{"v":3.52,"d":"3.520"},4,3,11]
["S6709","Obatoclax (GX15-070)","f4","L9900-08","in 10mM DMSO","Bcl-2","Apoptosis","Obatoclax (GX15-070) is an antagonist of Bcl-2 with an Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.",317.38,"803712-67-6",{"v":63,"d":"63.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://www.selleckchem.com/products/obatoclax-gx15-070.html","C20H19N3O","Free Base","N/A","COC1=CC(=NC1=CC2=C(C)C=C(C)[NH]2)C3=CC4=C([NH]3)C=CC=C4",{"v":4.17,"d":"4.170"},2,2,3]
["S7454","Azemiglitazone (MSDC-0602)","g4","L9900-08","in 10mM DMSO","Mitochondrial pyruvate carrier","Metabolism","Azemiglitazone (MSDC-0602) is a direct mitochondrial pyruvate carrier (MPC) inhibitor that modulates central carbon metabolism in mice and humans.",371.41,"1133819-87-0",{"v":82,"d":"82.00"},220.78,"<1","N/A","http://www.selleckchem.com/products/azemiglitazone-msdc-0602.html","C19H17NO5S","Free Base","N/A","COC1=CC=CC(=C1)C(=O)COC2=CC=C(CC3SC(=O)NC3=O)C=C2",{"v":3.31,"d":"3.310"},5,1,7]
["S9706","OT-82","h4","L9900-08","in 10mM DMSO","NAMPT","Metabolism","OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.",424.47,"1800487-55-1",{"v":85,"d":"85.00"},200.25,"<1","N/A","http://www.selleckchem.com/products/ot-82.html","C26H21FN4O","Free Base","N/A","FC1=CC=C(C=C1)C#CC2=CC(=CC=C2C3=CC=NC=C3)C(=O)NCCCC4=C[NH]N=C4",{"v":4.53,"d":"4.530"},3,2,8]
["S9925","Imeglimin (EMD 387008) Hydrochloride","a5","L9900-08","in 10mM DMSO","Others","Others","Imeglimin (EMD 387008, IMEG, PXL 008, RVT-1501) Hydrochloride is a new class of oral glucose-lowering agents. Imeglimin normalizes glucose tolerance and insulin sensitivity by preserving mitochondrial function from oxidative stress and favoring lipid oxidation in liver of HFHSD mice.",191.66,"775351-61-6",{"v":38,"d":"38.00"},198.27,{"v":38,"d":"38.00"},198.27,"http://www.selleckchem.com/products/imeglimin-emd-387008-hydrochloride.html","C6H13N5.ClH","Hydrochloride","PXL 008 Hydrochloride, RVT-1501 Hydrochloride, IMEG Hydrochloride","Cl.CC1N=C(N)NC(=N1)N(C)C",{"v":0.03,"d":"0.030"},2,2,1]
["E0054","Tegoprazan","b5","L9900-08","in 10mM DMSO","ATPase","Transmembrane Transporters","Tegoprazan (CJ-12420, IN-A001, K-CAB, LXI-15028, RQ-00000004) is a novel potent and highly selective inhibitor of gastric H+/K+-ATPase with IC50s ranging from 0.29 μM to 0.52 μM for  porcine, canine, and human H+/K+-ATPases in vitro, respectively.",387.38,"942195-55-3",{"v":77,"d":"77.00"},198.77,"<1","N/A","http://www.selleckchem.com/products/tegoprazan.html","C20H19F2N3O3","Free Base","CJ-12420, IN-A001, K-CAB, LXI-15028, RQ-00000004","CN(C)C(=O)C1=CC2=C(N=C(C)[NH]2)C(=C1)OC3CCOC4=C3C(=CC(=C4)F)F",{"v":2.89,"d":"2.890"},4,1,3]
["E0165","Phenelzine sulfate","c5","L9900-08","in 10mM DMSO","MAO","Neuronal Signaling","Phenelzine Sulfate is a hydrazine derivative and acts as a potent non-selective monoamine oxidase (MAO) inhibitor with an IC50 of 0.9 μM.",234.27,"156-51-4",{"v":47,"d":"47.00"},200.62,{"v":47,"d":"47.00"},200.62,"http://www.selleckchem.com/products/phenelzine-sulfate.html","C8H12N2.H2O4S","Sulfate","N/A","NNCCC1=CC=CC=C1.O[S](O)(=O)=O",{"v":0.31,"d":"0.310"},0,2,3]
["S0563","10-Deacetyl-7-xylosyl paclitaxel","d5","L9900-08","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.",943.98,"90332-63-1",{"v":100,"d":"100.00"},105.93,"<1","N/A","http://www.selleckchem.com/products/10-deacetyl-7-xylosyl-paclitaxel.html","C50H57NO17","free base","10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel","CC(=O)OC12COC1CC(OC3OCC(O)C(O)C3O)C4(C)C2C(OC(=O)C5=CC=CC=C5)C6(O)CC(OC(=O)C(O)C(NC(=O)C7=CC=CC=C7)C8=CC=CC=C8)C(=C(C(O)C4=O)C6(C)C)C",{"v":1.44,"d":"1.440"},11,6,14]
["S0747","DHODH-IN-11","e5","L9900-08","in 10mM DMSO","Dehydrogenase","Metabolism","DHODH-IN-11 is a Leflunomide derivative and a weak inhibitor of dihydroorotate dehydrogenase (DHODH).",265.27,"1263303-95-2",{"v":53,"d":"53.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/dhodh-in-11.html","C15H11N3O2","free base","N/A","O/N=C(C#N)/C(=O)NC1=CC=C(C=C1)C2=CC=CC=C2",2.437,2,1,3]
["S0767","NL-1","f5","L9900-08","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.",335.46,"188532-26-5",{"v":67,"d":"67.00"},199.73,"<1","N/A","http://www.selleckchem.com/products/nl-1.html","C18H25NO3S","free base","N/A","CC(C)(C)C1=C(O)C(=CC(=C1)CC2SC(=O)NC2=O)C(C)(C)C",4.644,2,2,4]
["S0770","Camalexin","g5","L9900-08","in 10mM DMSO","Fungal,ROS","Microbiology","Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities.",200.26,"135531-86-1",{"v":40,"d":"40.00"},199.74,"<1","N/A","http://www.selleckchem.com/products/camalexin.html","C11H8N2S","free base","N/A","[NH]1C=C(C2=NC=CS2)C3=C1C=CC=C3",2.504,1,1,1]
["S3543","DC-05","h5","L9900-08","in 10mM DMSO","DNA Methyltransferase","Epigenetics","DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively.",383.49,"890643-16-0",{"v":77,"d":"77.00"},200.79,"<1","N/A","http://www.selleckchem.com/products/dc-05.html","C25H25N3O","free base","N/A","OC(CNCCC1=C[NH]C2=CC=CC=C12)C[N]3C4=CC=CC=C4C5=CC=CC=C35",4.819,0,3,7]
["S6004","CCI-007","a6","L9900-08","in 10mM DMSO","Bcl-2","Apoptosis","CCI-007 is a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.",336.36,"939228-52-1",{"v":67,"d":"67.00"},199.19,"<1","N/A","http://www.selleckchem.com/products/cci-007.html","C15H16N2O5S","free base","N/A","CCOC(=O)COC1=CC=C(C=C1OC)\\C=C2\\SC(=NC2=O)N",2.019,6,1,7]
["S9951","MSDC-0602K Potassium","b6","L9900-08","in 10mM DMSO","Mitochondrial pyruvate carrier","Metabolism","MSDC-0602K is a insulin sensitizer that modulates the mitochondrial pyruvate carrier (MPC).",{"v":409.5,"d":"409.50"},"1314533-27-1",{"v":82,"d":"82.00"},200.24,"<1","N/A","http://www.selleckchem.com/products/msdc-0602k-potassium.html","C19H16NO5S.K","potassium salt","N/A","[K+].COC1=CC=CC(=C1)C(=O)COC2=CC=C(CC3SC(=O)[N-]C3=O)C=C2",3.412,5,0,7]
["E0051","SJ-172550","c6","L9900-08","in 10mM DMSO","MDM2/MDMX","Apoptosis","SJ 172550 is the first MDMX inhibitor that binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.",428.87,"431979-47-4",{"v":86,"d":"86.00"},200.53,"<1","N/A","http://www.selleckchem.com/products/sj-172550.html","C₂₂H₂₁ClN₂O₅","free base","N/A","CCOC1=C(OCC(=O)OC)C(=CC(=C1)\\C=C2/C(=NN(C2=O)C3=CC=CC=C3)C)Cl",4.456,6,0,8]
["E0483","Calmidazolium chloride","d6","L9900-08","in 10mM DMSO","ATPase,PDE","Metabolism","Calmidazolium chloride (R 24571) is a calmodulin (CaM) antagonist, antagonizing CaM-stimulated fraction of rat brain phosphodiesterase and CaM-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively, also shows a CaM-binding Kd value of 3 nM.",{"v":687.7,"d":"687.70"},"57265-65-3",{"v":100,"d":"100.00"},145.41,"<1","N/A","http://www.selleckchem.com/products/calmidazolium-chloride.html","C31H23Cl6N2O.Cl","Chloride","R 24571","[Cl-].ClC1=CC=C(C=C1)C([N]2C=C[N+](=C2)CC(OCC3=CC=C(Cl)C=C3Cl)C4=C(Cl)C=C(Cl)C=C4)C5=CC=C(Cl)C=C5",8.838,1,0,9]
["E0531","TMS","e6","L9900-08","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive human cytochrome P450s B1 (CYP1B1) inhibitor with an IC50 of 6 nM.",300.35,"24144-92-1",{"v":60,"d":"60.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/tms.html","C18H20O4","free base","(E)-2,3',4,5'-tetramethoxystilbene","COC1=CC=C(\\C=C\\C2=CC(=CC(=C2)OC)OC)C(=C1)OC",{"v":3.75,"d":"3.750"},4,0,6]
["E0671","Deacetylasperulosidic acid","f6","L9900-08","in 10mM DMSO","Antioxidant,SOD","Immunology & Inflammation","Deacetylasperulosidic acid, a major phytochemical constituent of Morinda citrifolia fruit, has antioxidant activity by increasing superoxide dismutase (SOD) activity, as well as anticlastogenic activity by suppressing the induction of chromosome aberrations in Chinese hamster ovary cells and mice.",390.34,"14259-55-3",{"v":78,"d":"78.00"},199.83,{"v":19,"d":"19.00"},48.68,"http://www.selleckchem.com/products/deacetylasperulosidic-acid.html","C16H22O11","free base","N/A","OCC1OC(OC2OC=C(C3C(O)C=C(CO)C23)C(O)=O)C(O)C(O)C1O",-3.326,4,6,5]
["E0745","AA147","g6","L9900-08","in 10mM DMSO","Others","Microbiology","AA147, a small molecule endoplasmic reticulum (ER) proteostasis regulator, selectively activates ATF6 arm of the unfolded protein response (UPR) extracted from patent WO2017117430A1, compound 147*.",255.31,"393121-74-9",{"v":51,"d":"51.00"},199.76,"<1","N/A","http://www.selleckchem.com/products/aa147.html","C16H17NO2","free base","N/A","CC1=CC=C(O)C(=C1)NC(=O)CCC2=CC=CC=C2",3.349,1,2,4]
["E0779","Paprotrain","h6","L9900-08","in 10mM DMSO","DYRK,Kinesin","Cell Cycle","Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.",245.28,"57046-73-8",{"v":49,"d":"49.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/paprotrain.html","C16H11N3","free base","N/A","N#C\\C(=C/C1=CN=CC=C1)C2=C[NH]C3=CC=CC=C23",2.798,1,1,2]
["E0788","PfDHODH-IN-2","a7","L9900-08","in 10mM DMSO","Dehydrogenase","Metabolism","PfDHODH-IN-2, a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (pfDHODH) inhibitor with an IC50 of 1.11 µM, acting as an antimalarial agent which can be used for the research of malaria.",297.76,"425629-94-3",{"v":8,"d":"8.00"},26.87,"<1","N/A","http://www.selleckchem.com/products/pfdhodh-in-2.html","C13H12ClNO3S","free base","N/A","CCOC(=O)C1=C(NC2=CC=C(Cl)C=C2)SCC1=O",3.107,3,1,5]
["E0808","BI-6C9","b7","L9900-08","in 10mM DMSO","Apoptosis related","Apoptosis","BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons.",{"v":471.6,"d":"471.60"},"791835-21-7",{"v":94,"d":"94.00"},199.32,"<1","N/A","http://www.selleckchem.com/products/bl-6C9.html","C23H25N3O4S2","free base","N/A","COC1=CC=C(C=C1)[S;v6](=O)(=O)NCCCC(=O)NC2=CC=C(SC3=CC=C(N)C=C3)C=C2",3.302,4,3,10]
["E0945","BIA","c7","L9900-08","in 10mM DMSO","Akt,Calcium Channel","Transmembrane Transporters","BIA (TMBIM6 antagonist BIA), a potential TMBIM6 antagonist, is an inhibitor of the interaction between TMBIM6 (Transmembrane B cell lymphoma 2-associated X protein (BAX) inhibitor motif-containing 6) and mTORC2, which ultimately blocks AKT activation and cancer progression.",268.27,"134271-74-2",{"v":54,"d":"54.00"},201.29,"<1","N/A","http://www.selleckchem.com/products/bia.html","C15H12N2O3","free base","TMBIM6 antagonist BIA","NC1=CC=CC=C1C(=O)\\C=C\\C2=CC=CC(=C2)[N+]([O-])=O",2.849,1,1,4]
["E1150","SIRT7 inhibitor 97491","d7","L9900-08","in 10mM DMSO","Sirtuin","Epigenetics","SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.",285.73,"1807758-81-1",{"v":57,"d":"57.00"},199.49,"<1","N/A","http://www.selleckchem.com/products/sirt7-inhibitor-97491.html","C15H12ClN3O","free base","N/A","NC1=CC=CC(=C1)NC2=NC=C(O2)C3=CC=C(Cl)C=C3",3.546,2,2,3]
["E1166","tetrathiomolybdate","e7","L9900-08","in 10mM DMSO","ATPase","Transmembrane Transporters","Tetrathiomolybdate (TM) is used in the clinic for the treatment of Wilson’s disease by inducing dimerization of the metal-binding domain of the cellular copper efflux protein ATP7B (WLN4) through a unique sulfur-bridged Mo2S6O2 cluster.",{"v":224.2,"d":"224.20"},"16330-92-0",{"v":45,"d":"45.00"},200.71,"<1","N/A","http://www.selleckchem.com/products/tetrathiomolybdate.html","MoS4","free base","N/A","S=[Mo--;v8](=S)(=S)=S",3.503,0,0,0]
["E1170","R162","f7","L9900-08","in 10mM DMSO","Dehydrogenase","Metabolism","R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.",264.28,"64302-87-0",{"v":7,"d":"7.00"},26.49,"<1","N/A","http://www.selleckchem.com/products/r162.html","C17H12O3","free base","N/A","OC1=C(CC=C)C=CC2=C1C(=O)C3=CC=CC=C3C2=O",3.574,2,1,2]
["E1178","FHD-286","g7","L9900-08","in 10mM DMSO","ATPase","Transmembrane Transporters","FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.",562.66,"2671128-05-3",{"v":100,"d":"100.00"},177.73,"<1","N/A","http://www.selleckchem.com/products/fhd-286.html","C24H30N6O6S2","free base","N/A","COCC(NC(=O)C1=C[N](C=C1)[S;v6](C)(=O)=O)C(=O)NC2=NC(=CS2)C3=CC=CC(=N3)N4CC(C)OC(C)C4",1.919,8,2,9]
["E2354","Valepotriate","h7","L9900-08","in 10mM DMSO","Bcl-2,Caspase,Decarboxylase,GABA Receptor","Transmembrane Transporters","Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.",422.47,"18296-44-1","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/valepotriate.html","C22H30O8","free base","N/A","CC(C)CC(=O)OC1OC=C(COC(C)=O)C2=CC(OC(=O)CC(C)C)C3(CO3)C12",2.193,8,0,11]
["E2365","Glutaminase C-IN-1","a8","L9900-08","in 10mM DMSO","Glutaminase","Proteases","Glutaminase C-IN-1 is an allosteric inhibitor of Glutaminase C (GAC) that inhibits cancer cell growth without affecting their normal cellular counterparts.",475.42,"311795-38-7",{"v":48,"d":"48.00"},100.96,"<1","N/A","http://www.selleckchem.com/products/glutaminase-c-in-1.html","C27H27BrN2O","free base","N/A","CN(C)C1=C(Br)C=C(C=C1)C2NC3=C(C4=C2C(=O)CC(C)(C)C4)C5=CC=CC=C5C=C3",6.181,1,1,2]
["E2632","Norharmane","b8","L9900-08","in 10mM DMSO","MAO","Neuronal Signaling","Norharmane (Norharman) is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM.",168.19,"244-63-3",{"v":34,"d":"34.00"},202.15,"<1","N/A","http://www.selleckchem.com/products/norharmane.html","C11H8N2","free base","Norharman, β-Carboline","[NH]1C2=C(C=CC=C2)C3=C1C=NC=C3",2.172,1,1,0]
["E2663","BT2","c8","L9900-08","in 10mM DMSO","Bcl-2","Apoptosis","BT2 is a novel branched-chain α-ketoacid dehydrogenase complex kinase (BDK) inhibitor wieh an IC50 of 3.19 μM.",{"v":247.1,"d":"247.10"},"34576-94-8",{"v":49,"d":"49.00"},{"v":198.3,"d":"198.30"},"<1","N/A","http://www.selleckchem.com/products/bt2.html","C9H4Cl2O2S","free base","N/A","OC(=O)C1=C(Cl)C2=CC=C(Cl)C=C2S1",3.941,1,0,1]
["E2829","Alkannin","d8","L9900-08","in 10mM DMSO","PKM","Metabolism","Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).",289.37,"517-88-4",{"v":100,"d":"100.00"},345.58,"<1","N/A","http://www.selleckchem.com/products/alkannin.html","C16H16O5","free base","N/A","CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O",2.444,2,3,3]
["E2832","LCS-1","e8","L9900-08","in 10mM DMSO","SOD","Metabolism","LCS-1 is an inhibitor of superoxide dismutase 1(SOD1) with IC50 of 1.07 μM.",{"v":255.1,"d":"255.10"},"41931-13-9",{"v":51,"d":"51.00"},199.92,"<1","N/A","http://www.selleckchem.com/products/lcs-1.html","C11H8Cl2N2O","free base","N/A","CC1=CC(=CC=C1)N2N=CC(=C(Cl)C2=O)Cl",2.701,2,0,1]
["S3290","Procyanidin B2","f8","L9900-08","in 10mM DMSO","NLRP3,PPAR","Metabolism","Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.",578.52,"29106-49-8",{"v":100,"d":"100.00"},172.85,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/procyanidin-b2.html","C30H26O12","free base","PCB2","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C(=C(O)C=C2O)C4C(O)C(OC5=CC(=CC(=C45)O)O)C6=CC(=C(O)C=C6)O",3.565,2,10,3]
["S6918","Oleandrin (PBI-05204)","g8","L9900-08","in 10mM DMSO","ATPase","Transmembrane Transporters","Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) is an inhibitor of Na+/K+-ATPase with IC50 of 0.62 μM. Oleandrin induces apoptosis and reduces migration of human glioma cells in vitro.",576.72,"465-16-7",{"v":100,"d":"100.00"},173.39,"<1","N/A","http://www.selleckchem.com/products/oleandrin-pbi-05204.html","C32H48O9","free base","Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol","COC1CC(OC(C)C1O)OC2CCC3(C)C(CCC4C3CCC5(C)C(C(CC45O)OC(C)=O)C6=CC(=O)OC6)C2",{"v":2.78,"d":"2.780"},7,1,6]
["E0680","Deslanoside","h8","L9900-08","in 10mM DMSO","ATPase","Transmembrane Transporters","Deslanoside(Desacetyllanatoside C) is a cardenolide glycoside, has the effects of anti-arrhythmia and cardiotonic, also is used as an EC 3.6.3.9 (Na+/K+-transporting ATPase) inhibitor.",943.08,"17598-65-1",{"v":100,"d":"100.00"},106.04,"<1","N/A","http://www.selleckchem.com/products/deslanoside.html","C47H74O19","free base","Desacetyllanatoside C","CC1OC(CC(O)C1OC2CC(O)C(OC3CC(O)C(OC4OC(CO)C(O)C(O)C4O)C(C)O3)C(C)O2)OC5CCC6(C)C(CCC7C6CC(O)C8(C)C(CCC78O)C9=CC(=O)OC9)C5",0.252,10,8,10]
["E2748","EGCG Octaacetate","a9","L9900-08","in 10mM DMSO","Others","Others","EGCG Octaacetate(AcEGCG) is a pro-drug of epigallocatechin-3-gallate (EGCG). EGCG have potent anti-oxidative, anti-mitotic and anti-angiogenic properties.",794.67,"148707-39-5",{"v":100,"d":"100.00"},125.84,"<1","N/A","http://www.selleckchem.com/products/egcg-octaacetate.html","C38H34O19","free base","AcEGCG","CC(=O)OC1=CC2=C(CC(OC(=O)C3=CC(=C(OC(C)=O)C(=C3)OC(C)=O)OC(C)=O)C(O2)C4=CC(=C(OC(C)=O)C(=C4)OC(C)=O)OC(C)=O)C(=C1)OC(C)=O",3.174,19,0,20]
["S0801","Spastazoline","b9","L9900-08","in 10mM DMSO","Others","Others","Spastazoline is a potent, cell-permeable and selective spastin (a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein) inhibitor with IC50 of 99 nM for Human spastin. Spastazoline does not inhibit ATPase activity of a recombinant human VPS4 (another AAA protein required for intercellular bridge disassembly).",382.51,"2351882-11-4",{"v":76,"d":"76.00"},198.69,"<1","N/A","http://www.selleckchem.com/products/spastazoline.html","C20H30N8","Free base","N/A","CC(C)C1CN(CCN1)C2=NC3=C(C=C[NH]3)C(=N2)NC4=N[NH]C(=C4)C(C)(C)C",4.633,3,4,5]
["S0922","Salvianolic acid C","c9","L9900-08","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Salvianolic acid C is a non-competitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2).",492.43,"115841-09-3",{"v":98,"d":"98.00"},199.01,"<1","N/A","http://www.selleckchem.com/products/salvianolic-acid-c.html","C26H20O10","Free base","N/A","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)/C=C/C2=C3C=C(OC3=C(O)C=C2)C4=CC(=C(O)C=C4)O",4.578,4,5,8]
["S1217","Cyclophosphamide","d9","L9900-08","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.",261.09,"50-18-0",{"v":52,"d":"52.00"},199.17,{"v":43,"d":"43.00"},164.69,"http://www.selleckchem.com/products/Clafen.html","C7H15Cl2N2O2P","Free base","NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane","ClCCN(CCCl)[P]1(=O)NCCCO1",0.144,2,1,5]
["S6036","ER-000444793","e9","L9900-08","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening with IC50 of 2.8 μM.",{"v":354.4,"d":"354.40"},"792957-74-5",{"v":71,"d":"71.00"},200.34,"<1","N/A","http://www.selleckchem.com/products/er-000444793.html","C23H18N2O2","Free base","N/A","O=C1NC2=CC=CC=C2C(=C1)C(=O)NC3=CC=CC=C3CC4=CC=CC=C4",3.972,2,2,4]
["S6594","Liarozole dihydrochloride","f9","L9900-08","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Liarozole Dihydrochloride is identified as a modest inhibitor of P450 with IC50 of 2.2–6.0 μM and 260 nM for CYP26 and rat CYP17 respectively.",381.69,"1883548-96-6",{"v":76,"d":"76.00"},199.11,{"v":76,"d":"76.00"},199.11,"http://www.selleckchem.com/products/liarozole-dihydrochloride.html","C₁₇H₁₅Cl₃N₄","Dihydrochloride","N/A","Cl.Cl.ClC1=CC=CC(=C1)C([N]2C=CN=C2)C3=CC4=C(C=C3)N=C[NH]4",4.062,2,1,3]
["S6675","(R)-GNE-140","g9","L9900-08","in 10mM DMSO","Dehydrogenase,LDH","Metabolism","(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.",499.04,"2003234-63-5",{"v":100,"d":"100.00"},200.38,"<1","N/A","http://www.selleckchem.com/products/r-gne-140.html","C25H23ClN2O3S2","Free base","N/A","OC1=C(SC2=C(Cl)C=CC=C2)C(=O)NC(C1)(C3=CSC=C3)C4=CC=C(C=C4)N5CCOCC5",4.316,2,2,5]
["S7739","Telacebec (Q203)","h9","L9900-08","in 10mM DMSO","Bacterial","Microbiology","Telacebec (Q203, IAP6) is a novel antituberculosis drug that targets Mycobacterium tuberculosis cellular energy production through inhibition of the mycobacterial cytochrome bc1 complex. Telacebec (Q203, IAP6) is active against Mycobacterium tuberculosis H37Rv with MIC50 of 2.7 nM in culture broth medium.",557.01,"1334719-95-7",{"v":20,"d":"20.00"},35.91,"<1","N/A","http://www.selleckchem.com/products/telacebec-q203.html","C29H28ClF3N4O2","Free base","IAP6","CCC1=C([N]2C=C(Cl)C=CC2=N1)C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(OC(F)(F)F)C=C5",7.887,3,1,8]
["S7770","1-Methoxy PMS","a10","L9900-08","in 10mM DMSO","Hydrotropic Agents","Others","1-methoxy PMS (1-Methoxy-5-methylphenazinium methyl sulfate) is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.",336.36,"65162-13-2",{"v":67,"d":"67.00"},199.19,{"v":23,"d":"23.00"},68.38,"https://www.selleckchem.com/products/1-methoxy-pms-.html","C15H16N2O5S","Free base","1-Methoxy-5-methylphenazinium methyl sulfate","COC1=CC=CC2=C1N=C3C=CC=CC3=[N+;v4]2C.CO[S;v6]([O-])(=O)=O",0.711,3,0,2]
["S7800","A-1155463 Dihydrochloride","b10","L9900-08","in 10mM DMSO","Bcl-2","Apoptosis","A-1155463 Dihydrochloride, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).",742.71,"1235034-55-5(free base)",{"v":80,"d":"80.00"},119.44,"<1","N/A","http://www.selleckchem.com/products/a-1155463.html","C35H34Cl2FN5O4S2","Dihydrochloride","N/A","CN(C)CC#CC1=CC=C(OCCCC2=C(N=C(S2)N3CCC4=CC=CC(=C4C3)C(=O)NC5=NC6=C(S5)C=CC=C6)C(O)=O)C(=C1)F\nClCl",6.213,5,1,12]
["S7801","A-1331852","c10","L9900-08","in 10mM DMSO","Bcl-2","Apoptosis","A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.",658.81,"1430844-80-6",{"v":100,"d":"100.00"},151.79,"<1","N/A","http://www.selleckchem.com/products/a-1331852.html","C38H38N6O3S","Free base","N/A","CC1=C(C=N[N]1CC23CC4CC(CC(C4)C2)C3)C5=CC=C(N=C5C(O)=O)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=C(S8)C=CC=C9",7.295,5,1,7]
["S8059","Nutlin-3a","d10","L9900-08","in 10mM DMSO","Apoptosis related,Autophagy,MDM2/MDMX,p53","Apoptosis","Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.",581.49,"675576-98-4",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://www.selleckchem.com/products/nutlin-3a.html","C30H30Cl2N4O4","Free base","(-)-Nutlin-3","COC1=CC(=C(C=C1)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)OC(C)C",5.434,5,1,6]
["S8129","Salinomycin (from Streptomyces albus)","e10","L9900-08","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Salinomycin (Coxistac, Bio-cox, Procoxacin), traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects.",{"v":751,"d":"751.00"},"53003-10-4",{"v":100,"d":"100.00"},133.16,"<1","N/A","http://www.selleckchem.com/products/salinomycin.html","C42H70O11","Free base","Coxistac, Bio-cox, Procoxacin","CCC(C1CCC(C)C(O1)C(C)C(O)C(C)C(=O)C(CC)C2OC3(OC4(CCC(C)(O4)C5CCC(O)(CC)C(C)O5)C(O)C=C3)C(C)CC2C)C(O)=O",5.904,7,2,12]
["S8758","VU661013","f10","L9900-08","in 10mM DMSO","Bcl-2","Apoptosis","VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.",712.66,"2131184-57-9",{"v":100,"d":"100.00"},140.32,"<1","N/A","http://www.selleckchem.com/products/vu661013.html","C39H39Cl2N5O4","Free base","N/A","CC1CN(C(=O)C2=C(CCCOC3=CC(=C(Cl)C(=C3)C)C)C4=CC=C(Cl)C(=C4[N]12)C5=C(C)[N](C)N=C5C)C6=C[N](C)C7=CC=C(C=C67)C(O)=O",9.178,4,0,8]
["S8881","DS-1001b (DS 1001)","g10","L9900-08","in 10mM DMSO","Dehydrogenase","Metabolism","DS-1001b is an oral selective inhibitor of mutant IDH1 R132X with potential antineoplastic activity and is designed to penetrate the blood-brain barrier.",608.92,"1898207-64-1",{"v":14,"d":"14.00"},22.99,"<1","N/A","http://www.selleckchem.com/products/ds-1001b.html","C29H29Cl3FN3O4","Free base","DS-1001","CC1=C[N](C(=O)C2=C(ON=C2C3=C(Cl)C=C(Cl)C=C3Cl)C(C)(C)F)C4=CC=CC(=C14)\\C=C\\C(O)=O.CC(C)(C)N",{"v":5.77,"d":"5.770"},4,1,5]
["S9612","ACBI1","h10","L9900-08","in 10mM DMSO","PROTAC","Others","ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.",{"v":936.1,"d":"936.10"},"2375564-55-7",{"v":100,"d":"100.00"},106.83,"<1","N/A","http://www.selleckchem.com/products/acbi1.html","C49H58FN9O7S","Free base","N/A","CC1=C(SC=N1)C2=CC(=C(CNC(=O)C3CC(O)CN3C(=O)C(NC(=O)C4(F)CC4)C(C)(C)C)C=C2)OCCOC5=CC=C(CN6CCN(CC6)C7=C(N)N=NC(=C7)C8=C(O)C=CC=C8)C=C5",4.962,8,5,17]
["S9970","APG-2575 (lisaftoclax)","a11","L9900-08","in 10mM DMSO","Bcl-2","Apoptosis","APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.",882.43,"2180923-05-9",{"v":100,"d":"100.00"},113.32,"<1","N/A","http://www.selleckchem.com/products/apg-2575-lisaftoclax.html","C45H48ClN7O8S","Free base","N/A","ClC1=CC=C(C=C1)C2=C(CCC3(CCC3)C2)CN4CCN(CC4)C5=CC(=C(C=C5)C(=O)N[S;v6](=O)(=O)C6=CC(=C(NCC7COCCO7)C=C6)[N;v5](=O)=O)OC8=CN=C9[NH]C=CC9=C8",7.191,7,3,13]
["E0355","CVT-10216","b11","L9900-08","in 10mM DMSO","Dehydrogenase","Metabolism","CVT-10216 is a highly selective, reversible inhibitor of ALDH-2 with an IC50 of 29 nM.",465.48,"1005334-57-5",{"v":93,"d":"93.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/cvt-10216.html","C24H19NO7S","Free base","N/A","C[S](=O)(=O)NC1=CC=C(C=C1)C2=COC3=C(C=CC(=C3)OCC4=CC(=CC=C4)C(O)=O)C2=O",2.974,6,1,7]
["E1037","ZZW-115","c11","L9900-08","in 10mM DMSO","Others","Others","ZZW-115 is a potent NUPR1 inhibitor with IC50s of 0.42 μM in Hep2G cells and 7.75 μM in SaOS-2 cells. ZZW-115 shows evident antitumor activity through its interaction with NUPR1.",573.97,"10122-45-9",{"v":93,"d":"93.00"},162.03,{"v":46,"d":"46.00"},80.14,"http://www.selleckchem.com/products/zzw-115.html","C₂₄H₃₄Cl₃F₃N₄S","Free base","N/A","Cl.Cl.Cl.CN(C)CCN1CCN(CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CC1",6.259,0,0,8]
["E1078","Emvododstat (PTC299)","d11","L9900-08","in 10mM DMSO","Dehydrogenase,VEGFR","Protein Tyrosine Kinase","Emvododstat(PTC299), a post-transcriptional inhibitor of pathogenic VEGF and dihydroorotate dehydrogenase(DHODH), inhibits VEGFA mRNA translation and abnormal cell proliferation. In HeLa cells PTC299 inhibits hypoxia-induced VEGFA protein production with an EC50 of 1.64 nM.",467.34,"1256565-36-2",{"v":93,"d":"93.00"},{"v":199,"d":"199.00"},"<1","N/A","http://www.selleckchem.com/products/emvododstat-ptc299.html","C25H20Cl2N2O3","Free base","N/A","COC1=CC=C(C=C1)C2N(CCC3=C2[NH]C4=C3C=C(Cl)C=C4)C(=O)OC5=CC=C(Cl)C=C5",{"v":6.86,"d":"6.860"},3,1,4]
["E1098","MF-094","e11","L9900-08","in 10mM DMSO","DUB","Ubiquitin","MF-094, a potent and selective USP30 inhibitor (IC50=0.12 μM), accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.",{"v":535.7,"d":"535.70"},"2241025-68-1",{"v":100,"d":"100.00"},186.67,"<1","N/A","http://www.selleckchem.com/products/mf-094.html","C30H37N3O4S","Free base","N/A","CC(C)(C)N[S](=O)(=O)C1=CC=CC2=C1C=CC=C2NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCCC4",4.927,4,3,9]
["E1139","DX3-213B","f11","L9900-08","in 10mM DMSO","OXPHOS","Apoptosis","DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, and impairs ATP generation with IC50 of 11 nM.",478.57,"2749555-66-4",{"v":96,"d":"96.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://www.selleckchem.com/products/dx3-213b.html","C20H28F2N2O5S2","Free base","N/A","CC(C)[S;v6](=O)(=O)C1=CC=C(C=C1)[S;v6](=O)(=O)N2CCCC(C2)C(=O)N3CCC(F)(F)CC3",2.041,5,0,5]
["E1149","BAY-179","g11","L9900-08","in 10mM DMSO","OXPHOS","Metabolism","BAY-179 is an excellent in vivo suitable tool with which to probe the biological relevance of complex I inhibition in cancer indications.",415.51,"2764880-87-5",{"v":5,"d":"5.00"},12.03,"<1","N/A","http://www.selleckchem.com/products/bay-179.html","C23H21N5OS","Free base","N/A","C1CN(CCC1C2=NC(=CS2)C3=CC4=CC=CC=C4O3)CC5=NC6=NC=CC=C6[NH]5",4.052,4,1,4]
["E0443","LDC195943 (IMT1)","h11","L9900-08","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.",{"v":351.4,"d":"351.40"},"2304621-31-4",{"v":70,"d":"70.00"},{"v":199.2,"d":"199.20"},"<1","N/A","https://www.selleckchem.com/products/ldc195943-imt1.html","C21H21NO4","free base","IMT1","CC(OC1=CC=C2C(=C1)OC(=O)C=C2C3=C(C)C=CC=C3)C(=O)N(C)C",3.598,4,0,4]
["E0444","LDC203974 (IMT1B)","a2","L9900-09","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. LDC203974 has anti-tumour effects.",473.88,"2304621-06-3",{"v":95,"d":"95.00"},200.47,"<1","N/A","https://www.selleckchem.com/products/ldc203974-imt1b.html","C24H21ClFNO6","free base","IMT1B","CC(OC1=CC=C2C(=C1)OC(=O)C=C2C3=C(Cl)C=C(F)C=C3)C(=O)N4CCCC(C4)C(O)=O",4.218,5,0,5]
["E1220","CBR-470-1","b2","L9900-09","in 10mM DMSO","phosphoglycerate kinase","Metabolism","CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade.",{"v":365.9,"d":"365.90"},"2416095-06-0",{"v":73,"d":"73.00"},199.51,"<1","N/A","https://www.selleckchem.com/products/cbr-470-1.html","C14H20ClNO4S2","chlorosulfate","N/A","CC(C)CNC1C[S](=O)(=O)CC1[S](=O)(=O)C2=CC=C(Cl)C=C2",2.289,4,1,5]
["E1328","TP-1454","c2","L9900-09","in 10mM DMSO","PKM","Metabolism","TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.",462.46,"2490276-04-3",{"v":92,"d":"92.00"},198.94,"<1","N/A","https://www.selleckchem.com/products/tp-1454.html","C19H22F4N4O3S","free base","N/A","NC1=CC=CC(=C1CN(CCC2CC[S](=O)(=O)CC2)C(=O)C3=CC(=N[NH]3)C(F)(F)F)F",2.929,4,2,7]
["E1353","AZD1656","d2","L9900-09","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","AZD1656 is a potent, selective and orally active activator of glucokinase. AZD1656 has the potential for type 2 diabetes research.",{"v":478.5,"d":"478.50"},"919783-22-5",{"v":96,"d":"96.00"},200.63,"<1","N/A","https://www.selleckchem.com/products/azd1656.html","C24H26N6O5","free base","N/A","COCC(C)OC1=CC(=CC(=C1)C(=O)NC2=NC=C(C)N=C2)OC3=NC=C(N=C3)C(=O)N4CCC4",0.887,9,1,9]
["E1368","PD173212","e2","L9900-09","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","PD173212(Compound 11) is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.",599.85,"217171-01-2",{"v":100,"d":"100.00"},166.71,"<1","N/A","https://www.selleckchem.com/products/pd173212.html","C38H53N3O3","free base","Compound 11","CC(C)CC(N(C)CC1=CC=C(C=C1)C(C)(C)C)C(=O)NC(CC2=CC=C(OCC3=CC=CC=C3)C=C2)C(=O)NC(C)(C)C",7.678,3,2,15]
["E1410","Fluspirilene","f2","L9900-09","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Fluspirilene(R 6218; Redeptin) is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM in cell-free assays. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia.",475.57,"1841-19-6",{"v":95,"d":"95.00"},199.76,"<1","N/A","https://www.selleckchem.com/products/fluspirilene.html","C29H31F2N3O","free base","R 6218, Redeptin","FC1=CC=C(C=C1)C(CCCN2CCC3(CC2)N(CNC3=O)C4=CC=CC=C4)C5=CC=C(F)C=C5",5.545,1,1,7]
["E2902","Sodium Pyruvate","g2","L9900-09","in 10mM DMSO","Others","Others","Sodium Pyruvate(Sodium 2-oxopropanoate) is a compound produced in the glycolytic pathway. Sodium Pyruvate is a free radical scavenger that can scavenge ROS.",111.05,"113-24-6",{"v":4,"d":"4.00"},36.02,{"v":22,"d":"22.00"},198.11,"https://www.selleckchem.com/products/sodium-pyruvate.html","C3H4O3.Na","sodium","Sodium 2-oxopropanoate","[Na;v0].CC(=O)C(O)=O",-0.329,2,0,1]
["E2926","A-1155463","h2","L9900-09","in 10mM DMSO","Bcl-2","Apoptosis","A-1155463 is a highly potent and selective BCL-XL inhibitor with EC50 of 65 nM in H146 cells.",669.79,"1235034-55-5",{"v":100,"d":"100.00"},{"v":149.3,"d":"149.30"},"<1","N/A","https://www.selleckchem.com/products/a--1155463.html","C35H32FN5O4S2","free base","N/A","CN(C)CC#CC1=CC(=C(OCCCC2=C(N=C(S2)N3CCC4=CC=CC(=C4C3)C(=O)NC5=NC6=CC=CC=C6S5)C(O)=O)C=C1)F",4.165,5,1,12]
["E2978","TMRE","a3","L9900-09","in 10mM DMSO","Dyes","Others","TMRE (Tetramethylrhodamine ethyl ester perchlorate, TMRE perchlorate) is a non-cytotoxic cell-permeant fluorogenic dye most commonly used to assess mitochondrial function using live cell fluorescence microscopy and flow cytometry.",514.96,"115532-52-0",{"v":100,"d":"100.00"},194.19,{"v":100,"d":"100.00"},194.19,"https://www.selleckchem.com/products/tmre.html","C26H27N2O3.ClO4","perchlorate","Tetramethylrhodamine ethyl ester perchlorate, TMRE perchlorate","CCOC(=O)C1=C(C=CC=C1)C2=C3C=CC(=CC3=[O+]C4=C2C=CC(=C4)N(C)C)N(C)C.[O-][Cl](=O)(=O)=O",2.994,2,0,6]
["E2984","GSK-7975A","b3","L9900-09","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","GSK-7975A is a potent and orally available inhibitor of CRAC channel. It reduces FcεRI-dependent Ca2+ influx and reduces the release of histamine, leukotriene C4, and cytokines (IL-5/-8/-13 and TNFα).",{"v":397.3,"d":"397.30"},"1253186-56-9",{"v":79,"d":"79.00"},198.84,"<1","N/A","https://www.selleckchem.com/products/gsk-7975a.html","C18H12F5N3O2","free base","N/A","OC1=CC(=C(C[N]2C=CC(=N2)NC(=O)C3=C(F)C=CC=C3F)C=C1)C(F)(F)F",4.498,2,2,5]
["E2988","Sulfosuccinimidyl oleate sodium","c3","L9900-09","in 10mM DMSO","Mitophagy","Autophagy","Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain with IC50 of 4 μM. It inhibits CD36 mediated LCFA transport. It exhibits anti-inflammatory effect.",482.59,"1212012-37-7",{"v":23,"d":"23.00"},47.66,"<1","N/A","https://www.selleckchem.com/products/sulfosuccinimidyl-oleate-sodium.html","C22H37NO7S.Na","sodium","N/A","[Na;v0].CCCCCCCCC=CCCCCCCCC(=O)ON1C(=O)CC(C1=O)[S](O)(=O)=O",{"v":5.4,"d":"5.400"},4,0,18]
["E2993","Ruthenium Red","d3","L9900-09","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye, which is a L-type calcium current  (ICa) blocker. It is  widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides.",786.35,"11103-72-3",{"v":100,"d":"100.00"},127.17,{"v":100,"d":"100.00"},127.17,"https://www.selleckchem.com/products/ruthenium-red.html","N/A","oxychloride","Ammoniated ruthenium oxychloride","N/A","N/A","N/A","N/A","N/A"]
["E4009","Sodium DL-lactate solution","e3","L9900-09","in 10mM DMSO","Others","Others","Sodium DL-lactate solution (60% w/w aq. soln.) is the product of glycogenolysis and glycolysis. It is mainly used as a buffer and pH adjuster for injection solutions. It also has antimicrobial activity, which can be used as a food preservative.",113.07,"72-17-3",{"v":23,"d":"23.00"},203.41,{"v":23,"d":"23.00"},203.41,"https://www.selleckchem.com/products/sodium-dl-lactate-solution.html","C3H6O3.Na","Sodium","N/A","[Na;v0].CC(O)C(O)=O",-0.393,1,1,1]
["S2949","KPLH1130","f3","L9900-09","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","KPLH1130 is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) that blocks macrophage polarization and attenuates proinflammatory responses.",283.28,"906669-07-6",{"v":57,"d":"57.00"},201.21,"<1","N/A","https://www.selleckchem.com/products/kplh1130.html","C15H13N3O3","free base","N/A","CC1=CC=C(C=C1)N2C(=O)NN=C2C3=C(O)C=C(O)C=C3",2.658,2,3,2]
["E1661","Adaptaquin","g3","L9900-09","in 10mM DMSO","HIF","Angiogenesis","Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin also inhibits lipid peroxidation and maintains mitochondrial function.",377.82,"385786-48-1",{"v":76,"d":"76.00"},201.15,"<1","N/A","https://www.selleckchem.com/products/adaptaquin.html","C21H16ClN3O2","free base","N/A","OC1=C(NC(C2=CC=C(Cl)C=C2)C3=C(O)C4=C(C=CC=N4)C=C3)N=CC=C1",4.589,2,3,4]
["E1735","PK11007","h3","L9900-09","in 10mM DMSO","p53","Apoptosis","PK11007 is a thiol-reactive anticancer agent that stabilizes  p53  via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant  p53  cancer cell death by increasing reactive oxygen species (ROS) levels.",427.86,"874146-69-7",{"v":86,"d":"86.00"},{"v":201,"d":"201.00"},"<1","N/A","https://www.selleckchem.com/products/pk11007.html","C15H11ClFN5O3S2","free base","N/A","CC1=NN=C(NC(=O)C2=NC(=NC=C2Cl)[S](=O)(=O)CC3=CC=C(F)C=C3)S1",2.499,7,1,5]
["E1780","Alexidine dihydrochloride","a4","L9900-09","in 10mM DMSO","phosphatase","Metabolism","Alexidine dihydrochloride, a dibiguanide compound, is an effective and selective inhibitor of  protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) with an IC50 of 1.08 μM in vitro. It has the potential to treat type II diabetes.",581.71,"1715-30-6",{"v":100,"d":"100.00"},171.91,{"v":6,"d":"6.00"},10.31,"https://www.selleckchem.com/products/alexidine-dihydrochloride.html","C26H56N10.2ClH","dihydrochloride","N/A","Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC",6.306,0,6,27]
["E4447","Coenzyme Q1","b4","L9900-09","in 10mM DMSO","Others","Others","Coenzyme Q1 (CoQ1) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. CoQ1 reduction has a strong rotenone-insensitive component and can be used to measure the mitochondrial respiratory chain complex 1 activity.",250.29,"727-81-1",{"v":50,"d":"50.00"},199.77,"<1","N/A","https://www.selleckchem.com/products/coenzyme-q1.html","C14H18O4","free base","CoQ1","COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)C",2.326,4,0,4]
["E1028","POMHEX","c4","L9900-09","in 10mM DMSO","Others","Metabolism","POMHEX,  is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer.",{"v":423.4,"d":"423.40"},"2004714-34-3",{"v":85,"d":"85.00"},200.76,{"v":5,"d":"5.00"},11.81,"https://www.selleckchem.com/products/pomhex.html","C17H30NO9P","phosphate","N/A","CC(C)(C)C(=O)OCO[P](=O)(OCOC(=O)C(C)(C)C)C1CCCN(O)C1=O",{"v":1.9,"d":"1.900"},7,0,11]
["E4016","Phenylarsine oxide","d4","L9900-09","in 10mM DMSO","phosphatase","Metabolism","Phenylarsine oxide (Oxophenylarsine) is a membrane-permeable protein tyrosine phosphatase inhibitor with IC50 18 µM. It Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle.",168.03,"637-03-6",{"v":25,"d":"25.00"},148.78,"<1","N/A","https://www.selleckchem.com/products/phenylarsine-oxide.html","C6H5AsO","free base","Oxophenylarsine","O=[As]C1=CC=CC=C1",1.655,0,0,1]
["P1079","Bax inhibitor peptide V5","e4","L9900-09","in 10mM DMSO","Bcl-2","Apoptosis","Bax inhibitor peptide V5 (BIP-V5 , BAX Inhibiting Peptide V5) is a cell-permeable pentapeptide that blocks the ku70 binding domain and prevents Bax conformational change and mitochondrial translocation. It Inhibits Bax-mediated apoptosis.",586.79,"579492-81-2",{"v":100,"d":"100.00"},170.42,{"v":100,"d":"100.00"},170.42,"https://www.selleckchem.com/products/Bax-inhibitor-peptide-V5.html","C27H50N6O6S","free base","N/A","N/A","N/A","N/A","N/A","N/A"]
["E4473","Lactate","f4","L9900-09","in 10mM DMSO","Others","Others","Lactate (Lactic acid) is the product of glycolysis, produced due to lack of oxygen in contracting skeletal muscle in vivo, and can be utilised under fully aerobic conditions. It plays a key role as a metabolic intermediate and can be used as hemodynamic marker and resuscitation endpoint in several cohorts of critically ill patients.",90.08,"50-21-5",{"v":18,"d":"18.00"},199.82,{"v":18,"d":"18.00"},199.82,"https://www.selleckchem.com/products/lactate.html","C3H6O3","free base","Lactic acid","CC(O)C(O)=O",-0.393,1,1,1]
["S1857","Etidronate","a2","L9900-10","in 10mM Water","phosphatase","Metabolism","Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.",206.03,"2809-21-4","<1","N/A",{"v":41,"d":"41.00"},{"v":199,"d":"199.00"},"http://selleckchem.com/products/etidronate-didronel.html","C2H8O7P2","free base","N/A","CC(O)([P](O)(O)=O)[P](O)(O)=O",-0.701,0,0,2]
["S1893","D-glutamine","b2","L9900-10","in 10mM Water","GluR","Neuronal Signaling","D-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code.",146.14,"5959-95-5","<1","N/A",{"v":9,"d":"9.00"},61.58,"http://selleckchem.com/products/D-glutamine.html","C5H10N2O3","free base","N/A","NC(CCC(N)=O)C(O)=O",-4.087,2,2,4]
["S2000","Sodium orthovanadate","c2","L9900-10","in 10mM Water","ATPase","Transmembrane Transporters","Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.",183.91,"13721-39-6","<1","N/A",{"v":36,"d":"36.00"},195.75,"http://selleckchem.com/products/Sodium-orthovanadate.html","Na3O4V","Sodium Salt","N/A","[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O",-3.177,0,0,0]
["S2518","NAD+","d2","L9900-10","in 10mM Water","Others","Others","NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.",663.43,"53-84-9","<1","N/A",{"v":100,"d":"100.00"},150.73,"http://selleckchem.com/products/nad.html","C21H27N7O14P2","free base","β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide","NC(=O)C1=CC=C[N+](=C1)C2OC(CO[P]([O-])(=O)O[P](O)(=O)OCC3OC(C(O)C3O)[N]4C=NC5=C(N)N=CN=C45)C(O)C2O",-4.524,9,6,11]
["S3631","(S)-Methylisothiourea sulfate","e2","L9900-10","in 10mM Water","ROS","Immunology & Inflammation","(S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS).",139.19,"867-44-7","<1","N/A",{"v":27,"d":"27.00"},193.98,"http://selleckchem.com/products/s-methylisothiourea-sulfate.html","C2H6N2S.1/2H2SO4","sulfate","N/A","CSC(N)=N",1.158,0,1,1]
["S3852","L-Theanine","f2","L9900-10","in 10mM Water","Others","Others","L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation.",{"v":174.2,"d":"174.20"},"3081-61-6","<1","N/A",{"v":34,"d":"34.00"},195.18,"http://selleckchem.com/products/l-theanine.html","C7H14N2O3","free base","N/A","CCNC(=O)CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3973","L-SelenoMethionine","g2","L9900-10","in 10mM Water","ROS","Immunology & Inflammation","L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.",196.11,"3211-76-5","<1","N/A",{"v":39,"d":"39.00"},198.87,"http://selleckchem.com/products/l-selenomethionine.html","C5H11NO2Se","free base","N/A","C[Se]CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4013","Sodium Monofluorophosphate","h2","L9900-10","in 10mM Water","phosphatase","Metabolism","Sodium Monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.",143.95,"10163-15-2","<1","N/A",{"v":29,"d":"29.00"},201.46,"http://selleckchem.com/products/sodium-monofluorophosphate.html","FNa2O3P","Disodium salt","NSC248","[Na+].[Na+].[O-][P]([O-])(F)=O",-2.357,0,0,0]
["S4298","Amifostine trihydrate","a3","L9900-10","in 10mM Water","Others","Others","Amifostine trihydrate(WR2721 trihydrate) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.",268.27,"112901-68-5","<1","N/A",{"v":42,"d":"42.00"},156.56,"http://selleckchem.com/products/amifostine.html","C5H15N2O3PS.3H2O","trihydrate","WR2721 trihydrate","O.O.O.NCCCNCCS[P](O)(O)=O",-1.471,0,2,7]
["S4606","Glutathione","b3","L9900-10","in 10mM Water","Glutathione","Metabolism","Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.",307.32,"70-18-8","<1","N/A",{"v":61,"d":"61.00"},198.49,"http://selleckchem.com/products/glutathione.html","C10H17N3O6S","free base","Isethion, Glutathion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine","NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O",-4.772,4,3,9]
["S4740","Sodium ferulate","c3","L9900-10","in 10mM Water","5-HT Receptor","Neuronal Signaling","Sodium ferulate (SF, Ferulic acid sodium salt), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.",216.17,"24276-84-4",{"v":2,"d":"2.00"},9.25,{"v":43,"d":"43.00"},198.92,"http://selleckchem.com/products/ferulic-acid-sodium.html","C10H9O4.Na","Sodium salt","Ferulic acid sodium salt","[Na+].COC1=CC(=CC=C1O)\\C=C\\C([O-])=O",0.195,1,1,3]
["S4786","S-Methyl-L-cysteine","d3","L9900-10","in 10mM Water","Others","Others","S-Methyl-L-cysteine (S-Methylcysteine) is one of the identified number of bioactive substances in garlic that are water soluble that may exert some chemopreventive effects on chemical carcinogenesis.",135.18,"1187-84-4","<1","N/A",{"v":27,"d":"27.00"},199.73,"http://selleckchem.com/products/s-methyl-l-cysteine.html","C4H9NO2S","free base","S-Methylcysteine","CSCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4827","Manganese chloride","e3","L9900-10","in 10mM Water","Others","Others","Manganese chloride occurs in nature as the mineral. It is used as a precursor for other manganese compounds.",125.84,"7773-01-5","N/A","N/A",{"v":100,"d":"100.00"},794.66,"http://selleckchem.com/products/manganese-chloride.html","MnCl2","free base","N/A","Cl[Mn]Cl",0.971,0,0,0]
["S5097","Methotrexate disodium","f3","L9900-10","in 10mM Water","Dehydrogenase,DHFR","Metabolism","Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.",{"v":498.4,"d":"498.40"},"7413-34-5","<1","N/A",{"v":99,"d":"99.00"},198.64,"http://selleckchem.com/products/methotrexate-disodium.html","C20H20N8O5.2Na","disodium salt","N/A","[Na+].[Na+].CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O",-2.834,5,3,9]
["S5107","Riboflavin phosphate sodium","g3","L9900-10","in 10mM Water","Others","Others","Flavin mononucleotide (riboflavin-5'-phosphate, FMN) is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors.",478.33,"130-40-5","<1","N/A",{"v":39,"d":"39.00"},81.53,"http://selleckchem.com/products/flavin-mononucleotide.html","C17H20N4NaO9P","phosphate sodium","Flavin mononucleotide, riboflavin-5'-phosphate, FMN, Vitamin B2 Phosphate Sodium Salt","[Na+].CC1=CC2=C(C=C1C)N(CC(O)C(O)C(O)CO[P](O)([O-])=O)C3=NC(=O)NC(=O)C3=N2",{"v":0,"d":"0.000"},0,0,0]
["S5226","L-carnosine","h3","L9900-10","in 10mM Water","Others","Others","L-carnosine (Karnozin) is an antioxidant naturally found in skeletal muscle, brain tissue, and the heart that protects cells against oxidative stress.",226.23,"305-84-0","<1","N/A",{"v":45,"d":"45.00"},198.91,"http://selleckchem.com/products/l-carnosine.html","C9H14N4O3","free base","Karnozin","NCCC(=O)NC(CC1=C[NH]C=N1)C(O)=O",-4.268,3,3,6]
["S5340","3-Aminopropionitrile fumarate","a4","L9900-10","in 10mM Water","Others","Others","3-Aminopropionitrile fumarate (Beta-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine.",256.26,"2079-89-2","<1","N/A",{"v":51,"d":"51.00"},199.02,"http://selleckchem.com/products/3-aminopropionitrile-fumarate.html","C4H4O4.2C3H6N2","fumarate","Beta-Aminopropionitrile fumarate","NCCC#N.NCCC#N.OC(=O)\\C=C\\C(O)=O",-6.257,2,2,4]
["S5545","DL-Serine","b4","L9900-10","in 10mM Water","PKM","Metabolism","Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.",105.09,"302-84-1","<1","N/A",{"v":8,"d":"8.00"},76.13,"http://selleckchem.com/products/dl-serine.html","C3H7NO3","salt","N/A","NC(CO)C(O)=O",-4.049,1,2,2]
["S5584","Citronellol","c4","L9900-10","in 10mM Water","Apoptosis related,Caspase,RIP kinase,ROS,TNF-alpha","Apoptosis","Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.",156.27,"106-22-9","<1","N/A",{"v":31,"d":"31.00"},198.37,"http://selleckchem.com/products/citronellol.html","C10H20O","free base","Dihydrogeraniol, (±)-β-Citronellol","CC(CCO)CCC=C(C)C",3.049,0,1,5]
["S5588","Creatine","d4","L9900-10","in 10mM Water","IFN,JAK","JAK/STAT","Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.",131.13,"57-00-1","<1","N/A",{"v":26,"d":"26.00"},198.28,"http://selleckchem.com/products/creatine.html","C4H9N3O2","free base","Methylguanidoacetic acid","CN(CC(O)=O)C(N)=N",-1.095,1,1,3]
["S6103","Inosine 5′-triphosphate trisodium salt","e4","L9900-10","in 10mM Water","Others","Others","Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes.",574.11,"35908-31-7","N/A","N/A",{"v":114,"d":"114.00"},198.57,"http://www.selleck.cn/products/inosine-5-triphosphate-trisodium-salt.html","C10H12N4Na3O14P3","trisodium salt","N/A","[Na+].[Na+].[Na+].OC1C(O)C(OC1CO[P]([O-])(=O)O[P]([O-])(=O)O[P](O)([O-])=O)[N]2C=NC3=C2N=CNC3=O",-7.316,7,3,8]
["S6222","Ethyl potassium malonate","f4","L9900-10","in 10mM Water","Dehydrogenase","Metabolism","Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate.",{"v":170.2,"d":"170.20"},"6148-64-7","N/A","N/A",34.04,{"v":200,"d":"200.00"},"http://www.selleck.cn/products/ethyl-potassium-malonate.html","C5H7KO4","free base","Potassium 3-ethoxy-3-oxopropanoate, Malonic Acid Monoethyl Ester Potassium Salt","[K+].CCOC(=O)CC([O-])=O",-1.294,2,0,4]
["S6325","Adenosine 5′-diphosphate sodium salt","g4","L9900-10","in 10mM Water","Others","Others","Adenosine 5′-diphosphate (ADP, Adenosine diphosphate, Adenosine 5′-pyrophosphate, Adenosine pyrophosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP).",{"v":427.2,"d":"427.20"},"20398-34-9","N/A","N/A",85.44,{"v":200,"d":"200.00"},"http://www.selleck.cn/products/adenosine-5-diphosphate-sodium-salt.html","C10H15N5O10P2.xNa","sodium salt","Adenosine diphosphate sodium salt, ADP sodium salt, Adenosine 5′-pyrophosphate sodium salt, Adenosine pyrophosphate sodium salt","NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(=O)O[P](O)(O)=O)C(O)C3O",-1.505,6,3,6]
["S7873","Disodium (R)-2-Hydroxyglutarate","h4","L9900-10","in 10mM Water","ROS","Immunology & Inflammation","Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 10.87 ± 1.85 mM.",192.08,"103404-90-6","<1","N/A",{"v":38,"d":"38.00"},197.83,"http://selleckchem.com/products/disodium-r-2-hydroxyglutarate.html","C5H6Na2O5","disodium salt","D-α-Hydroxyglutaric acid disodium","OC(CCC(=O)O[Na])C(=O)O[Na]",-0.509,4,1,6]
["S7901","Ac-DEVD-CHO","a5","L9900-10","in 10mM Water","Caspase","Apoptosis","Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.",502.47,"169332-60-9","N/A","N/A",{"v":100,"d":"100.00"},199.02,"http://selleckchem.com/products/ac-devd-cho.html","C20H30N4O11","free base","Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO","CC(C)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(=O)NC(CC(O)=O)C=O",{"v":-2.7,"d":"-2.700"},8,4,16]
["S8199","Ruxotemitide (LTX 315)","b5","L9900-10","in 10mM Water","Bcl-2","Apoptosis","Ruxotemitide (LTX 315, Oncopore) is the oncolytic peptide that kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.",1439.79,"1345407-05-7","N/A","N/A",{"v":100,"d":"100.00"},69.45,"http://selleckchem.com/products/ltx-315.html","C78H106N18O9","free base","Oncopore","NCCCCC(N)C(=O)NC(CCCCN)C(=O)NC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC3=C[NH]C4=C3C=CC=C4)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC5=C[NH]C6=C5C=CC=C6)C(=O)NC(C(C7=CC=CC=C7)C8=CC=CC=C8)C(=O)NC(CCCCN)C(N)=O",3.102,9,18,46]
["S8651","bpV (HOpic)","c5","L9900-10","in 10mM Water","PTEN","PI3K/Akt/mTOR","bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.",347.24,"722494-26-0","<1","N/A",{"v":69,"d":"69.00"},198.71,"http://selleckchem.com/products/bpv-hopic.html","C6H4NO8V.2K","potassium","Bisperoxovanadium (HOpic)","[K+].[K+].OC1=CC=C2N(=C1)|[V+3]|3|4(|[O-][O-]|3)(|[O-][O-]|4)(|[O-]C2=O)=O",-1.876,0,1,0]
["S4933","Lithium carbonate","d5","L9900-10","in 10mM Water","Dopamine Receptor","Neuronal Signaling","Lithium carbonate (Li2CO3) is an inorganic compound that is valuable and effective agent in the treatment and prophylaxis of mood disorders, particularly bipolar disorder (BD). Lithium carbonate is able to alter D2 dopamine receptors response.",73.89,"554-13-2","N/A","N/A","N/A",{"v":10,"d":"10.00"},"https://www.selleckchem.com/products/lithium-carbonate.html","CLi2O3","Salt","Li2CO3","[LiH].[Li]OOC=O",-0.347,2,0,2]
["S6871","Sodium oxamate","e5","L9900-10","in 10mM Water","Apoptosis related,CDK,LDH,ROS","Metabolism","Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.",111.03,"565-73-1","<1","N/A",{"v":22,"d":"22.00"},198.14,"http://www.selleckchem.com/products/sodium-oxamate.html","C2H2NNaO3","Sodium","SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt","[Na+].NC(=O)C([O-])=O",-2.531,1,1,1]
["S8620","6-Diazo-5-oxo-L-norleucine","f5","L9900-10","in 10mM Water","Glutaminase","Proteases","6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON), an antibiotic isolated from Streptomyces, is a glutaminase antagonist with IC50 of ~1  mM for cKGA (kidney-type glutaminase). 6-Diazo-5-oxo-L-norleucine exhibits analgesic, antibacterial, antiviral and anticancer properties.",171.15,"157-03-9","<1","N/A",{"v":34,"d":"34.00"},198.66,"http://www.selleckchem.com/products/6-diazo-5-oxo-l-norleucine.html","C6H9N3O3","free base","Diazooxonorleucine, 6-Diazo-5-oxo-L-nor-Leucine, L-6-Diazo-5-oxonorleucine, DON","NC(CCC(=O)C=[N+]=[N-])C(O)=O",-3.117,2,1,5]
["S9665","Motixafortide (BL-8040)","g5","L9900-10","in 10mM Water","Apoptosis related,Bcl-2,CDK,CXCR,ERK,MicroRNA","Immunology & Inflammation","Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.",2159.52,"664334-36-5",{"v":-1,"d":"-1.00"},-0.46,{"v":100,"d":"100.00"},46.31,"http://www.selleckchem.com/products/motixafortide-bl-8040-.html","C97H144FN33O19S2","free base","BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140","NCCCCC1NC(=O)C(CCCNC(N)=O)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CSSCC(NC(=O)C(CCCNC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC3=CC=C(O)C=C3)NC(=O)C4CCCN4C(=O)C(CCCCN)NC1=O)C(=O)NC(CCCNC(N)=N)C(N)=O)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C7=CC=C(F)C=C7",-3.895,17,30,53]
["S1325","L-2-Hydroxyglutaric acid disodium","h5","L9900-10","in 10mM Water","Histone Demethylase","Epigenetics","L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.",192.08,"63512-50-5","<1","N/A",{"v":38,"d":"38.00"},197.83,"https://www.selleckchem.com/products/l-2-hydroxyglutaric-acid-disodium.html","C5H6Na2O5","Disodium","(S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG","[Na+].[Na+].OC(CCC([O-])=O)C([O-])=O",-3.639,0,1,4]
["S3096","L-Histidine monohydrochloride monohydrate","a6","L9900-10","in 10mM Water","Others","Metabolism","L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.",209.63,"5934-29-2","<1","N/A",{"v":42,"d":"42.00"},200.35,"https://www.selleckchem.com/products/l-histidine-monohydrochloride-monohydrate.html","C6H12ClN3O3","Monohydrate","L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O","O.Cl.NC(CC1=CN=C[NH]1)C(O)=O",-3.538,2,2,3]
["S9803","Elamipretide (MTP-131)","b6","L9900-10","in 10mM Water","Mitochondrial Metabolism,Peroxidases","Metabolism","Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.",639.79,"736992-21-5",{"v":-1,"d":"-1.00"},"N/A",{"v":100,"d":"100.00"},{"v":156.3,"d":"156.30"},"http://www.selleckchem.com/products/elamipretide-mtp-131.html","C32H49N9O5","Free Base","SS-31, D-Arg-Dmt-Lys-Phe-NH2","CC1=C(CC(NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC2=CC=CC=C2)C(N)=O)C(=CC(=C1)O)C",0.416,4,9,20]
["E0134","L-Albizziin","c6","L9900-10","in 10mM Water","Glutaminase","Proteases","L-albizziin (L-alpha-amino-beta-ureidopropionic acid) is a potent inhibitor of glutamase. L-albizziin interferes with the utilisation of L-glutamine by the Debaryomyces spp. enzyme probably in a competitive and reversible manner since L-albizziin is also a substrate of the enzyme.",147.13,"1483-07-4","<1","N/A",{"v":29,"d":"29.00"},{"v":197.1,"d":"197.10"},"http://www.selleckchem.com/products/l-albizziin.html","C4H9N3O3","Free Base","L-alpha-amino-beta-ureidopropionic acid","NC(CNC(N)=O)C(O)=O",{"v":-4.53,"d":"-4.530"},2,3,3]
["E0375","Ammonium ferric citrate","d6","L9900-10","in 10mM Water","Ferroptosis","Apoptosis","Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.",978.05,"1185-57-5","<1","N/A",{"v":53,"d":"53.00"},54.19,"http://www.selleckchem.com/products/ammonium-ferric-citrate.html","C24H32Fe3N3O28","Citrate","Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz","[NH4+].[NH4+].[NH4+].[Fe+3].[Fe+3].[Fe+3].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O",{"v":-28.54,"d":"-28.540"},0,0,20]
["E2692","L-Ascorbic acid 2-phosphate sesquimagnesium salt","e6","L9900-10","in 10mM Water","phosphatase,RUNX","Metabolism","L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.",289.54,"113170-55-1","<1","N/A",{"v":14,"d":"14.00"},23.93,"http://www.selleckchem.com/products/l-ascorbic-acid-2-phosphate-sesquimagnesium-salt.html","C6H9O9P.3/2Mg","sesquimagnesium salt","2-Phospho-L-ascorbic acid magnesium","[Mg++].[Mg++].[Mg++].OCC(O)C1OC(=O)C(=C1[O-])O[P]([O-])([O-])=O.OCC(O)C2OC(=O)C(=C2[O-])O[P]([O-])([O-])=O",-8.592,6,4,8]
["S8187","ReACp53","f6","L9900-10","in 10mM Water","p53","Apoptosis","ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).",2617.13,"N/A","<1","N/A",{"v":100,"d":"100.00"},38.21,"http://www.selleckchem.com/products/reacp53.html","C108H206N52O24","Free base","N/A","CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CCCNC(N)=N)C(C)CC)C(C)O)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(O)=O",-14.672,20,42,104]
["E1246","D-AP5","g6","L9900-10","in 10mM Water","NMDAR","Neuronal Signaling","D-AP5 (D-APV; D-2-Amino-5-phosphonovaleric acid) is a selective and competitive NMDA receptor antagonist that inhibits the glutamate binding site of NMDA receptors.",197.13,"79055-68-8","<1","N/A",{"v":39,"d":"39.00"},197.84,"https://www.selleckchem.com/products/d-ap5.html","C5H12NO5P","Free base","N/A","NC(CCC[P](O)(O)=O)C(O)=O",-3.632,1,1,5]
["E2979","DL-AP5 (2-APV)","h6","L9900-10","in 10mM Water","NMDAR","Neuronal Signaling","DL-AP5 (2-APV, DL-2-Amino-5-phosphonovaleric acid) is a competitive antagonist of NMDA (N-methyl-D-aspartate) receptor. It shows significantly antinociceptive activity and specifically blocks on channels in the rabbit retina.",197.13,"76326-31-3","<1","N/A",{"v":39,"d":"39.00"},197.84,"https://www.selleckchem.com/products/dl-ap5-2-apv.html","C5H12NO5P","Free base","DL-2-Amino-5-phosphonovaleric acid","NC(CCC[P](O)(O)=O)C(O)=O",-3.632,1,1,5]
["E1689","NADPH tetrasodium salt","a7","L9900-10","in 10mM Water","Others","Others","NADPH tetrasodium salt is a ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes. It plays a crucial role as a cofactor in the biosynthesis of nucleotides, proteins, and fatty acids. It is essential for neutralizing elevated levels of reactive oxygen species (ROS) generated by increased metabolic activity.",837.38,"2646-71-1","<1","N/A",{"v":100,"d":"100.00"},119.42,"https://www.selleckchem.com/products/nadph-tetrasodium-salt.html","C21H30N7O17P3.4Na","Tetrasodium","N/A","[NaH].NC(=O)C1=CN(C=CC1)C2OC(CO[P](O)(=O)O[P](O)(=O)OCC3OC(C(O[P](O)(O)=O)C3O)[N]4C=NC5=C(N)N=CN=C45)C(O)C2O",-4.131,10,5,13]
["S1046","Vandetanib (ZD6474)","a2","L9900-11","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1","N/A","http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1327","Ellagic acid","b2","L9900-11","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Ellagic acid (Elagostasine, Gallogen) has antiproliferative and antioxidant property.",302.19,"476-66-4",{"v":3,"d":"3.00"},9.93,"<1","N/A","http://selleckchem.com/products/Ellagic-acid.html","C14H6O8","free base","Elagostasine, Gallogen","OC1=CC2=C3C(=C1O)OC(=O)C4=CC(=C(O)C(=C34)OC2=O)O",{"v":0,"d":"0.000"},0,0,0]
["S1837","Flubendazole","c2","L9900-11","in 2mM DMSO","Autophagy,Parasite","Autophagy","Flubendazole (Flumoxanal, NSC 313680) is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.",313.28,"31430-15-6",{"v":3,"d":"3.00"},9.58,"<1","N/A","http://selleckchem.com/products/flubendazole-flutelmium.html","C16H12FN3O3","free base","Flumoxanal, NSC 313680","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)C(=O)C3=CC=C(F)C=C3",{"v":3.26,"d":"3.260"},4,2,4]
["S4033","Sennoside A","d2","L9900-11","in 2mM DMSO","MAO","Metabolism","Sennoside A (NSC 112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.",862.74,"81-27-6","N/A",{"v":2,"d":"2.00"},"<1","N/A","http://selleckchem.com/products/sennoside-a.html","C42H38O20","Free Base","NSC 112929","OCC1OC(OC2=CC=CC3=C2C(=O)C4=C(O)C=C(C=C4C3C5C6=C(C(=O)C7=C(O)C=C(C=C57)C(O)=O)C(=CC=C6)OC8OC(CO)C(O)C(O)C8O)C(O)=O)C(O)C(O)C1O",0.409,8,10,9]
["S6606","CDD3505","e2","L9900-11","in 2mM DMSO","P450 (e.g. CYP17)","Metabolism","CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.",355.39,"173865-33-3",{"v":2,"d":"2.00"},5.63,"<1","N/A","http://www.selleck.cn/products/cdd3505.html","C22H17N3O2","Free Base","N/A","[O-][N+](=O)C1=C[N](C=N1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4",4.991,1,0,5]
["S7105","BAM7","f2","L9900-11","in 2mM DMSO","Bcl-2","Apoptosis","BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.",405.47,"331244-89-4",{"v":2,"d":"2.00"},4.93,"<1","N/A","http://selleckchem.com/products/bam7.html","C21H19N5O2S","Free Base","N/A","CCOC1=CC=CC=C1N\\N=C2/C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C",{"v":4.1,"d":"4.100"},5,1,6]
["S7790","A-1210477","g2","L9900-11","in 2mM DMSO","Bcl-2","Apoptosis","A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.",850.04,"1668553-26-1",{"v":3,"d":"3.00"},3.53,"<1","N/A","http://selleckchem.com/products/a-1210477.html","C46H55N7O7S","Free Base","N/A","CN(C)[S](=O)(=O)N1CCN(CC1)C2=CC=C(OCC3=C(C(=N[N]3C)C)C4=C5[N](CCN6CCOCC6)C(=C(CCCOC7=C8C=CC=CC8=CC=C7)C5=CC=C4)C(O)=O)C=C2",3.151,7,0,16]
["S9067","Pseudoprotodioscin","h2","L9900-11","in 2mM DMSO","Immunology & Inflammation related,MicroRNA,SREBP","Immunology & Inflammation","Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.",1031.18,"102115-79-7",{"v":10,"d":"10.00"},{"v":9.7,"d":"9.70"},"N/A","N/A","https://www.selleckchem.com/products/pseudoprotodioscin.html","C51H82O21","free base","OP31761","CC(CCC1=C(C)C2C(CC3C4CC=C5CC(CCC5(C)C4CCC23C)OC6OC(CO)C(OC7OC(C)C(O)C(O)C7O)C(O)C6OC8OC(C)C(O)C(O)C8O)O1)COC9OC(CO)C(O)C(O)C9O",-0.502,9,12,14]
["E0124","Chelerythrine","a3","L9900-11","in 2mM DMSO","Bcl-2,PKC","TGF-beta/Smad","Chelerythrine (Toddaline, Broussonpapyrine) is a potent, selective antagonist of PKC with an IC50 of 0.66 μM. Chelerythrine also inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM. Chelerythrine shows antitumor, antidiabetic and anti-inflammatory activity.",348.37,"34316-15-9",{"v":2,"d":"2.00"},5.74,"<1","N/A","http://www.selleckchem.com/products/chelerythrine.html","C21H18NO4","Free Base","Toddaline, Broussonpapyrine","COC1=C(OC)C2=C[N+](=C3C(=C2C=C1)C=CC4=CC5=C(OCO5)C=C34)C",{"v":4.19,"d":"4.190"},4,0,2]
["E0784","MAO-B-IN-2","b3","L9900-11","in 2mM DMSO","BChE,MAO","Neuronal Signaling","MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively.",310.73,"1253978-24-3",{"v":3,"d":"3.00"},9.65,"<1","N/A","http://www.selleckchem.com/products/mao-b-in-2.html","C18H11ClO3","free base","N/A","ClC1=CC=CC=C1/C=C/C(=O)C2=CC3=CC=CC=C3OC2=O",4.386,3,0,3]
["S9464","Tranylcypromine Sulfate","c3","L9900-11","in 2mM DMSO","MAO","Metabolism","Tranylcypromine (Parnate) is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.",364.46,"13492-01-8",{"v":2,"d":"2.00"},5.49,"<1","N/A","http://www.selleckchem.com/products/tranylcypromine-sulfate.html","C18H24N2O4S","Sulfate","Parnate","NC1CC1C2=CC=CC=C2.NC3CC3C4=CC=CC=C4.O[S;v6](O)(=O)=O",{"v":1.78,"d":"1.780"},0,2,2]